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  • SAGE Publications  (49)
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  • SAGE Publications  (49)
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  • 1
    Online Resource
    Online Resource
    Preparation and antitumor effects of 4-amino-1,2,4-triazole Schiff base derivative
    SAGE Publications ; 2020
    In:  Journal of International Medical Research Vol. 48, No. 2 ( 2020-02), p. 030006052090387-
    Details
    In: Journal of International Medical Research, SAGE Publications, Vol. 48, No. 2 ( 2020-02), p. 030006052090387-
    Type of Medium: Online Resource
    ISSN: 0300-0605 , 1473-2300
    URL: Article
    DOI: 10.1177/0300060520903874
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2082422-1
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  • 2
    Online Resource
    Online Resource
    Bayesian dynamic linear model framework for structural health monitoring data forecasting and missing data imputation during typhoon events
    SAGE Publications ; 2022
    In:  Structural Health Monitoring Vol. 21, No. 6 ( 2022-11), p. 2933-2950
    Details
    In: Structural Health Monitoring, SAGE Publications, Vol. 21, No. 6 ( 2022-11), p. 2933-2950
    Abstract: A Bayesian dynamic linear model (BDLM) framework for data modeling and forecasting is proposed to evaluate the performance of an operational cable-stayed bridge, that is, Ting Kau Bridge in Hong Kong, by using SHM strain field data acquired. One of the major challenges in dealing with the existing in-service bridge under extreme typhoon loads is to forecast structural behavior using the typhoon response exhibiting non-stationarity, large data fluctuations and strong randomness. The first attempt for SHM data modeling during extreme events, that is, typhoons, using BDLM framework, was conducted in this study. The data from multiple sensors are analyzed for one-step, multi-step ahead forecasting and missing data imputation. The overall bridge behavior is incorporated into a forecasting model by superposition of forecasting results of trend (representing the structural baseline response), periodic component (response component evolving regularly over time), and autoregressive component (time-dependent error) through BDLM algorithm. The results demonstrate that the BDLM framework yielded more accurate calculations compared with Gaussian process and Variational Heteroscedasticity Gaussian Process methods with respect to one-step ahead forecasting for strain data under typhoons. Multi-step ahead forecasting was successfully carried out both for non-typhoon and typhoon responses within an acceptable precision range. The correlation between periodic component and temperature was also investigated. Regarding missing data imputation, BLDM algorithm can generate robust results due to making full use of the monitoring data both before and after the missing segments.
    Type of Medium: Online Resource
    ISSN: 1475-9217 , 1741-3168
    URL: Article
    DOI: 10.1177/14759217221079529
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2101420-6
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  • 3
    Online Resource
    Online Resource
    Towards high-precision data modeling of SHM measurements using an improved sparse Bayesian learning scheme with strong generalization ability
    SAGE Publications ; 2023
    In:  Structural Health Monitoring
    Details
    In: Structural Health Monitoring, SAGE Publications
    Abstract: Central to structural health monitoring (SHM) is data modeling, manipulation, and interpretation on the basis of a sophisticated SHM system. Despite continuous evolution of SHM technology, the precise modeling and forecasting of SHM measurements under various uncertainties to extract structural condition-relevant knowledge remains a challenge. Aiming to resolve this problem, a novel application of a fully probabilistic and high-precision data modeling method was proposed in the context of an improved Sparse Bayesian Learning (iSBL) scheme. The proposed iSBL data modeling framework features the following merits. It can remove the need to specify the number of terms in the data-fitting function, and automatize sparsity of the Bayesian model based on the features of SHM monitoring data, which will enhance the generalization ability and then improve the data prediction accuracy. Embedded in a Bayesian framework which exhibits built-in protection against over-fitting problems, the proposed iSBL scheme has high robustness to data noise, especially for data forecasting. The model is verified to be effective on SHM vibration field monitoring data collected from a real-world large-scale cable-stayed bridge. The recorded acceleration data with two different vibration patterns, that is, stationary ambient vibration data and non-stationary decay vibration data, are investigated, returning accurate probabilistic predictions in both the time and frequency domains.
    Type of Medium: Online Resource
    ISSN: 1475-9217 , 1741-3168
    URL: Article
    DOI: 10.1177/14759217231170316
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2101420-6
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  • 4
    Online Resource
    Online Resource
    Daxx ameliorates abdominal aortic aneurysm through inhibiting the TGF-β1-mediated PI3K/AKT/ID2 signaling pathway
    SAGE Publications ; 2022
    In:  European Journal of Inflammation Vol. 20 ( 2022-01), p. 1721727X2210915-
    Details
    In: European Journal of Inflammation, SAGE Publications, Vol. 20 ( 2022-01), p. 1721727X2210915-
    Abstract: Abdominal aortic aneurysm (AAA) is a potentially life-threatening vascular abnormality, that, if ruptured, is almost universally fatal without repair, and is associated with up to 50% mortality even if repaired in hospital. To date, there is no drug therapy that has clinically proven benefit to reduce or prevent expansion of AAA. The aim of this study was to investigate whether Daxx could affect AAA through inhibiting the PI3K/AKT/ID2 signaling pathway mediated by transforming growth factor β-1 (TGFβ1). Methods The AAA model was constructed by injecting angiotensin Ⅱ (Ang-Ⅱ) into rats, and the Daxx lentivirus vector was constructed. Hematoxylin and eosin (HE) staining was used to detect the wall thickness of the abdominal aorta in rats. The gene and protein expressions in abdominal aortic tissues were detected utilizing western blot, immunohistochemistry (IHC) and fluorescence quantitative real-time polymerase chain reaction (qRT-PCR). Finally, the concentration of TGF-β1 in abdominal aortic tissue was determined by ELISA. Results The abdominal aortic wall thickness was decreased in the Daxx expression group (by HE staining), and Daxx overexpression markedly reduced the protein expression levels of MMP2 and MMP9. Proteins related to the PI3K/AKT/ID2 signaling pathway were highly enhanced in the aneurysm wall of rats, but were reduced following Daxx addition. Moreover, Daxx reduced the damage to elastin (by IHC), and the expression levels of α-SMA and SM22α were up-regulated by Daxx (by qRT-PCR). The concentration of TGF-β1 was correlated with the activation of the PI3K/AKT/ID2 signaling pathway (by ELISA), whereas AKT overexpression weakened the inhibitory effect of Daxx. Conclusion Daxx ameliorated several mechanisms that contributed to expansion of AAA suppressing the tissue concentration of TGF-β1, thereby inhibiting the activation of the PI3K/AKT/ID2 signaling pathway. This evidence might form the basis to develop a therapeutic target for AAA.
    Type of Medium: Online Resource
    ISSN: 1721-727X , 2058-7392
    URL: Article
    DOI: 10.1177/1721727X221091532
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2584683-8
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  • 5
    Online Resource
    Online Resource
    Empagliflozin improves chronic hypercortisolism-induced abnormal myocardial structure and cardiac function in mice
    SAGE Publications ; 2020
    In:  Therapeutic Advances in Chronic Disease Vol. 11 ( 2020-01), p. 204062232097483-
    Details
    In: Therapeutic Advances in Chronic Disease, SAGE Publications, Vol. 11 ( 2020-01), p. 204062232097483-
    Abstract: Chronic exposure to excess glucocorticoids is frequently associated with a specific cardiomyopathy. Empagliflozin, a sodium-glucose cotransporter 2 (SGLT2) inhibitor, has beneficial effects as it aids in the reduction of heart failure and cardiovascular mortality in hospitalized patients. The aim of this study was to investigate the effects of empagliflozin on chronic hypercortisolism-induced myocardial fibrosis and myocardial dysfunction in mice. Methods: Male C57BL/6J mice (6 weeks old) were randomized to control, corticosterone (CORT), and empagliflozin + CORT groups. After 4 weeks of administration, heart structure and function were evaluated by echocardiography, and peripheral blood and tissue samples were collected. Expressions of Ccl2, Itgax, Mrc1, and Adgre1 mRNA in heart tissue were evaluated by RT-PCR, and signal transducer and activator of transcription 3 (STAT3) and Toll-like receptor 4 (TLR4) protein expression were analyzed by Western blotting. Results: Empagliflozin effectively reduced body weight, liver triglyceride, visceral adipose volume, and uric acid in CORT-treated mice. Left ventricular hypertrophy and cardiac dysfunction were improved significantly, phosphorylated STAT3 and TLR4 were alleviated, and macrophage infiltration in the myocardium was inhibited after administration of empagliflozin in CORT-treated mice. Conclusion: Empagliflozin has beneficial effects on specific cardiomyopathy associated with CORT, and the results provide new evidence that empagliflozin might be a potential drug for the prevention of this disease.
    Type of Medium: Online Resource
    ISSN: 2040-6223 , 2040-6231
    URL: Article
    DOI: 10.1177/2040622320974833
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2554816-5
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  • 6
    Online Resource
    Online Resource
    Circulating tumor cells dynamics during chemotherapy predict survival and response in advanced non-small-cell lung cancer patients
    SAGE Publications ; 2023
    In:  Therapeutic Advances in Medical Oncology Vol. 15 ( 2023-01), p. 175883592311678-
    Details
    In: Therapeutic Advances in Medical Oncology, SAGE Publications, Vol. 15 ( 2023-01), p. 175883592311678-
    Abstract: Circulating tumor cells (CTCs) are prognostic biomarker in non-small-cell lung cancer (NSCLC). CTCs could also be used as predictor of efficacy of systemic treatments in advanced NSCLC. Objectives: We described the dynamic changes of CTCs during first-line platinum-based chemotherapy in advanced NSCLC and clarified the correlation between CTC counts and efficacy of chemotherapy. Design: Chemotherapy is administered and blood specimens are collected at four time points from baseline to disease progression for CTC detection. Methods: This multicenter prospective study enrolled patients with previously untreated stage III or IV NSCLC fit for standard platinum-based chemotherapy. Bloods were sampled as per standard operating procedures at baseline, cycle 1 and cycle 4 of chemotherapy, and at disease progression for CTC analysis using the CellSearch system. Results: Among 150 patients enrolled, median overall survival (OS) was 13.8, 8.4, and 7.9 months in patients with CTC − , KIT − CTC, and KIT + CTC at baseline ( p = 0.002). Patients with persistent negative CTC (46.0%) had longer progression-free survival [5.7 months, 95% confidence interval (CI): 5.0–6.5 versus 3.0 months, 0.6–5.4; hazard ratio (HR): 0.34, 95% CI: 0.18–0.67) and OS (13.1 months, 10.9–15.3 versus 5.6 months, 4.1–7.1; HR: 0.17, 0.08–0.36) compared with patients with persistent positive CTC (10.7%), which was not impacted by chemotherapy. Chemotherapy decreased CTC from 36.0% (54/150) to 13.7% (13/95). Conclusions: CTC persistent presence during treatment represents poor prognosis and resistance to chemotherapy in advanced NSCLC. Chemotherapy could effectively eliminate CTCs. Molecular characterization and the functionalization of CTC will be warranted for further intensive investigation. Trial registration: NCT01740804.
    Type of Medium: Online Resource
    ISSN: 1758-8359 , 1758-8359
    URL: Article
    DOI: 10.1177/17588359231167818
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2503443-1
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  • 7
    Online Resource
    Online Resource
    Optimal target range for blood glucose in hyperglycaemic patients in a neurocritical care unit
    SAGE Publications ; 2014
    In:  Diabetes and Vascular Disease Research Vol. 11, No. 5 ( 2014-09), p. 352-358
    Details
    In: Diabetes and Vascular Disease Research, SAGE Publications, Vol. 11, No. 5 ( 2014-09), p. 352-358
    Abstract: Hyperglycaemia is common among patients with critical neurological injury, even if they have no history of diabetes. The optimal target range for normalizing their blood glucose is unknown. Methods: Retrospective data were extracted from 890 hyperglycaemic individuals (glucose 〉 200 mg/dL) admitted to neuroscience critical care unit (NCCU) and these patients were divided into two groups: intensive glucose control group with target glucose of 〈 140 mg/dL achieved and moderate control with glucose levels 140-180 mg/dL. The groups were also stratified according to the hyperglycaemia type (pre-existing diabetes or stress-related). We defined the primary endpoint as death from any cause during NCCU admission. Results: In NCCU, tighter control of blood glucose at ≤ 140 mg/dL was associated with increased, mortality of individuals with pre-existing diabetes compared with moderate control [29 of 310 patients (9.4%) vs 15 of 304 patients (4.9%), p = 0.034] . Patient age [adjusted odds ratio (OR) = 1.12; 95% confidence interval (CI) = 1.05–1.19; p 〈 0.001], level of glycated haemoglobin (adjusted OR = 1.24; 95% CI = 1.04–1.48; p = 0.017) and hypoglycaemia (adjusted OR = 10.3; 95% CI = 2.92–36.6; p 〈 0.001) were positively associated with higher mortality. Death rate was lower among stress-related hyperglycaemic patients with tighter glucose controlled at ≤ 140 mg/dL [6 of 140 patients (4.3%) vs 15 of 136 patients (11.0%), p = 0.035]. Conclusion: A differential association is evident between glucose levels and mortality in diabetes and stress-related hyperglycaemia patients. However, given the observational nature of our work, no clinical recommendations can be given and prospective studies are required to further investigate these findings.
    Type of Medium: Online Resource
    ISSN: 1479-1641 , 1752-8984
    URL: Article
    DOI: 10.1177/1479164114530580
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2014
    detail.hit.zdb_id: 2250797-8
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  • 8
    Online Resource
    Online Resource
    Comparative Proteome Analysis of Human Lung Squamous Carcinoma using Two Different Methods: Two-Dimensional Gel Electrophoresis and iTRAQ Analysis
    SAGE Publications ; 2012
    In:  Technology in Cancer Research & Treatment Vol. 11, No. 4 ( 2012-08), p. 395-408
    Details
    In: Technology in Cancer Research & Treatment, SAGE Publications, Vol. 11, No. 4 ( 2012-08), p. 395-408
    Abstract: Discovery of early-diagnosis biomarkers is the key to improve the early-diagnosis and prognosis of human lung squamous carcinoma (hLSC). In order to identify more exhaustive and systematic protein biomarkers for early-diagnosis of hLSC, we chose LCM purified cells from hLSC tissues and paired normal bronchial epithelia(NBE) tissues and used two methods, the classical 2-DE/MS approach and the new iTRAQ analysis. We found a total of 63 differential proteins, 22 proteins in 2-DE and 59 proteins in iTRAQ analysis, between hLSC and NBE tissues. Among them, 18 proteins were quantified using both methods. The expression level of 15 proteins (68.2%) in 2-DE was consistent with that in iTRAQ analysis. Series of proteins involved in cytoskeleton, chaperone, GTP binding, metabolic process, cell apoptosis, cell proliferation and differentiation, signal transduction, transcription and translation were identified, suggesting their possible role in the emergence of oncogenic pathways leading to carcinogenesis of hLSC. These proteins may make as potential biomarkers for diagnosis of hLSC. The two methods gave us closely related but different information about proteins, suggesting they are complementary or at least supplementary methods at present. Our results show both the usefulness of iTRAQ reagent technology for identification of further potential marker proteins as well as for prevalidation of biomarker.
    Type of Medium: Online Resource
    ISSN: 1533-0346 , 1533-0338
    URL: Article
    DOI: 10.7785/tcrt.2012.500287
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2012
    detail.hit.zdb_id: 2146365-7
    detail.hit.zdb_id: 2220436-2
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  • 9
    Online Resource
    Online Resource
    Functional Results of All-Inside Arthroscopic Broström-Gould Surgery With 2 Anchors Versus Single Anchor
    SAGE Publications ; 2020
    In:  Foot & Ankle International Vol. 41, No. 6 ( 2020-06), p. 721-727
    Details
    In: Foot & Ankle International, SAGE Publications, Vol. 41, No. 6 ( 2020-06), p. 721-727
    Abstract: The all-inside arthroscopic Broström-Gould technique gained particular attention among clinicians and researchers due to its high rate of satisfactory results. Thus far, there is a lack of evidence regarding the differences in clinical outcomes between the use of 1 anchor and 2 anchors. The purpose of this study was to compare the differences in clinical function and activity levels in patients treated with 1 or 2 anchors in all-inside arthroscopic Broström-Gould surgery for chronic lateral ankle instability (CLAI). Methods: The data of 75 patients with CLAI (unilateral) admitted from May 2013 to July 2016 were retrospectively analyzed. All patients were treated with all-inside arthroscopic Broström-Gould surgery. The patients were divided into a single-anchor group ( n = 36) and double-anchor group ( n = 39) according to the number of anchors used. There was no statistical difference in general characteristics between the 2 groups before surgery. After 36 to 72 months of follow-up, the pain visual analog scale (VAS) score, American Orthopaedic Foot & Ankle Society (AOFAS) score, Karlsson Ankle Functional Score (KAFS), and Foot and Ankle Outcome Score (FAOS) were used to evaluate and compare the clinical function results between the 2 groups. Results: The incidence of wound complications; reaction to the suture; injury to the nerve, blood vessel, or tendon; and length of postoperative hospitalization were similar between the 2 groups. At the last follow-up, there was no significant difference in the VAS and AOFAS scores between single- and double-anchor groups, but the KAFS and FAOS in the double-anchor group were significantly higher than in the single-anchor group. Additionally, more patients in the double-anchor group returned to preinjury sports activities. Conclusion: All-inside arthroscopic Broström-Gould surgery for the treatment of CLAI yielded a better functional effect and better recovery to preinjury mobility when 2 anchors were used instead of a single anchor. Level of Evidence: Level III, comparative study.
    Type of Medium: Online Resource
    ISSN: 1071-1007 , 1944-7876
    URL: Article
    DOI: 10.1177/1071100720908858
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2129503-7
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  • 10
    Online Resource
    Online Resource
    Electroacupuncture may alleviate behavioral defects via modulation of gut microbiota in a mouse model of Parkinson’s disease
    SAGE Publications ; 2021
    In:  Acupuncture in Medicine Vol. 39, No. 5 ( 2021-10), p. 501-511
    Details
    In: Acupuncture in Medicine, SAGE Publications, Vol. 39, No. 5 ( 2021-10), p. 501-511
    Abstract: Parkinson’s disease (PD) is a chronic neurodegenerative disease involving non-motor symptoms, of which gastrointestinal disorders are the most common. In light of recent results, intestinal dysfunction may be involved in the pathogenesis of PD. Electroacupuncture (EA) has shown potential effects, although the underlying mechanism remains mostly unknown. We speculated that EA could relieve the behavioral defects of PD, and that this effect would be associated with modulation of the gut microbiota. Methods: Mice were randomly divided into three groups: control, PD + MA (manual acupuncture), and PD + EA. MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) was used to establish the mouse model of PD. Rotarod performance tests, open field tests, and pole tests were carried out to assess motor deficiencies. Immunohistochemistry was conducted to examine the survival of dopaminergic neurons. 16S ribosomal RNA (rRNA) gene sequencing was applied to investigate the alterations of the gut microbiome. Quantitative real-time polymerase chain reaction (PCR) was performed to characterize the messenger RNA (mRNA) levels of pro-inflammatory and anti-inflammatory cytokines. Results: We found that EA was able to alleviate the behavioral defects in the rotarod performance test and pole test, and partially rescue the significant loss of dopaminergic neurons in the substantia nigra (SN) chemically induced by MPTP in mice. Moreover, the PD + MA mice showed a tendency toward decreased intestinal microbial alpha diversity, while EA significantly reversed it. The abundance of Erysipelotrichaceae was significantly increased in PD + MA mice, and the alteration was also reversed by EA. In addition, the pro-inflammatory cytokines interleukin (IL)-6 and tumor necrosis factor (TNF)-α were substantially increased in the SN of PD + MA mice, an effect that was reversed by EA. Conclusion: These results suggest that EA may alleviate behavioral defects via modulation of gut microbiota and suppression of inflammation in the SN of mice with PD, which provides new insights into the pathogenesis of PD and its treatment.
    Type of Medium: Online Resource
    ISSN: 0964-5284 , 1759-9873
    URL: Article
    DOI: 10.1177/0964528421990658
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2126127-1
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