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  • 1
    Online Resource
    Online Resource
    SAGE Publications ; 2022
    In:  Proceedings of Singapore Healthcare Vol. 31 ( 2022-06), p. 201010582211388-
    In: Proceedings of Singapore Healthcare, SAGE Publications, Vol. 31 ( 2022-06), p. 201010582211388-
    Abstract: Survival after heart transplantation (HT) has improved considerably since the first HT was performed in 1967 in Cape Town, South Africa. Understanding immunology behind organ rejection has paved way for advances in the assessment of pre-transplant compatibility, development of newer and more specific immunosuppressive drugs, and management of rejection. Objectives Unlike medical therapy for heart failure, transplant protocols vary considerably between different centers. These variations in protocols generally reflect unique population characteristics and the availability of resources. This review article aims to provide a consolidated update on contemporary cardiac transplant medicine. We also aim to highlight local practice and its difference from our international counterparts. Methods A literature search was performed on Pubmed and Cochrane Central Register of Controlled Trials to identify trials and review articles that discussed heart transplant immunology and protocols. The International Society for Heart and Lung Transplant (ISHLT) guidelines were also reviewed. We focused on risk factors, prevention strategies, and treatment of cardiac rejection. Results A total of 48 articles were selected to provide a comprehensive overview of the contemporary practice of cardiac transplant immunosuppressive therapy. Comparisons were made with local data and practice protocols to highlight key differences. Conclusion Heart transplant covers a small subset of cardiac patients and much of the evidence is derived from empirical observations and retrospective analysis. This accounts for the heterogeneity in care and treatment protocols. More studies are needed to select best practices from around the world to further improve outcomes.
    Type of Medium: Online Resource
    ISSN: 2010-1058 , 2059-2329
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2831421-9
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  • 2
    Online Resource
    Online Resource
    SAGE Publications ; 2015
    In:  Proceedings of Singapore Healthcare Vol. 24, No. 3 ( 2015-09), p. 133-133
    In: Proceedings of Singapore Healthcare, SAGE Publications, Vol. 24, No. 3 ( 2015-09), p. 133-133
    Type of Medium: Online Resource
    ISSN: 2010-1058 , 2059-2329
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2015
    detail.hit.zdb_id: 2831421-9
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  • 3
    Online Resource
    Online Resource
    SAGE Publications ; 2022
    In:  Proceedings of Singapore Healthcare Vol. 31 ( 2022-06), p. 201010582211297-
    In: Proceedings of Singapore Healthcare, SAGE Publications, Vol. 31 ( 2022-06), p. 201010582211297-
    Abstract: Ossifying fibromyxoid tumour (OFMT) is a soft tissue neoplasm of uncertain differentiation, with potential for recurrences and metastases depending on the presence of atypical or malignant histological features. Most cases show an incomplete shell of mature bone in the periphery of the lesion. Recurrent PHF1 gene rearrangements were also recently reported in OFMTs, with the most common rearrangement involving a fusion to EP400. We report a case of a 75-year-old male that was diagnosed with an OFMT showing an unusually prominent central ossification. Further, this lesion also harboured the less commonly reported EPC1-PHF1 gene fusion, thus further characterising the morphological features that are associated with this molecular event in this entity. Differential diagnoses of lesions with prominent ossification and emerging molecular findings associated with this entity are discussed.
    Type of Medium: Online Resource
    ISSN: 2010-1058 , 2059-2329
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2831421-9
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  • 4
    Online Resource
    Online Resource
    SAGE Publications ; 2016
    In:  Proceedings of Singapore Healthcare Vol. 25, No. 2 ( 2016-06), p. 105-111
    In: Proceedings of Singapore Healthcare, SAGE Publications, Vol. 25, No. 2 ( 2016-06), p. 105-111
    Abstract: Dural arteriovenous fistulae (DAVF) constitute 10–15% of all intracranial vascular malformations. As a subtype of DAVF, tentorial DAVF are even rarer, but their aggressive nature warrants early intervention. With regards to symptoms, 70–88% of the cases present with bruits or tinnitus, 60–74% with intracranial haemorrhages, 23–42% with central nerve deficits, 14–17% with cranial nerve deficits, and finally 8–25 % with headaches. Here we report three cases of tentorial DAVF with a primary manifestation of headaches: the first patient is a 44-year-old woman who presented with a severe, persistent sharp occipital headache for 1 day. She deteriorated quickly after admission and required emergency posterior fossa decompression for evacuation of an acute right cerebellar haematoma. Intra-operative and pathological findings suggested a cerebellar arteriovenous malformation. She subsequently underwent transarterial embolisation and surgical excision of the lesion. A review of the histopathological features will be presented. The second case is a 61-year-old male with a 3–4-day history of headache and vomiting prior to presenting to the emergency department with acute delirium secondary to subarachnoid haemorrhage in the posterior fossa. The third case is a 55-year-old woman with moderate, recurrent generalised headaches for 4–5 years. She was managed expediently with transarterial embolisation and had a good outcome. In view of the poor prognosis associated with DAVF rupture, early diagnosis and treatment is warranted to achieve favourable outcomes.
    Type of Medium: Online Resource
    ISSN: 2010-1058 , 2059-2329
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2016
    detail.hit.zdb_id: 2831421-9
    Library Location Call Number Volume/Issue/Year Availability
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  • 5
    Online Resource
    Online Resource
    SAGE Publications ; 2014
    In:  Proceedings of Singapore Healthcare Vol. 23, No. 4 ( 2014-12), p. 292-296
    In: Proceedings of Singapore Healthcare, SAGE Publications, Vol. 23, No. 4 ( 2014-12), p. 292-296
    Abstract: Proper certification of death has legal, social, and epidemiological significance. There is unfortunately little in the existing medical literature relevant to such an important issue in Singapore. With the implementation of the Coroners Act 2010, there has been recent surge in interest in this matter, highlighting a need for additional instruction on the accurate completion of death certificates. This review explains how a death certificate should be filled out, with particular focus on the difference between the terms cause, mechanism, mode, and manner of death. The article is aimed at doctors in Singapore, and highlights legal and practical issues.
    Type of Medium: Online Resource
    ISSN: 2010-1058 , 2059-2329
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2014
    detail.hit.zdb_id: 2831421-9
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  • 6
    Online Resource
    Online Resource
    SAGE Publications ; 2024
    In:  Journal of Medical Education and Curricular Development Vol. 11 ( 2024-01)
    In: Journal of Medical Education and Curricular Development, SAGE Publications, Vol. 11 ( 2024-01)
    Abstract: There is an increasing availability of digital technologies for teaching and learning of human anatomy. Studies have shown that such applications allow for better spatial awareness than traditional methods. These digital human anatomy platforms offer users myriad features, such as the ability to manipulate 3D models, conduct prosection, investigate anatomical regions through virtual reality, or perform knowledge tests on themselves. This study examined what faculty members’ value when using digital human anatomy platforms for teaching and what students value when using these platforms for learning. METHODS Six anatomy faculty members and 21 students were selected to participate in this study. After using the three digital anatomy platforms for at least 1 week, a survey was conducted to record their feedback in 4 categories: usability, interactive features, level of detail, and learning support. Respondents’ Qualitative feedback within each category was also analyzed to strengthen the study's findings. RESULTS The study's findings showed that faculty members and students have different priorities when evaluating digital anatomy platforms. Faculty members valued platforms that provided better accuracy and detailed anatomical structures, while students prioritized usability above the rest of the features. CONCLUSION Given that faculty and students have different preferences when selecting digital anatomy platforms, this article proposed that educators maximize the specific affordances offered by the technology by having a clear pedagogy and strategy on how the technology will be incorporated into the curriculum to help students achieve the desired learning outcomes.
    Type of Medium: Online Resource
    ISSN: 2382-1205 , 2382-1205
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2024
    detail.hit.zdb_id: 2798123-X
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  • 7
    Online Resource
    Online Resource
    SAGE Publications ; 2014
    In:  Proceedings of Singapore Healthcare Vol. 23, No. 1 ( 2014-03), p. 1-2
    In: Proceedings of Singapore Healthcare, SAGE Publications, Vol. 23, No. 1 ( 2014-03), p. 1-2
    Type of Medium: Online Resource
    ISSN: 2010-1058 , 2059-2329
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2014
    detail.hit.zdb_id: 2831421-9
    Library Location Call Number Volume/Issue/Year Availability
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