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  • SAGE Publications  (115)
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  • 1
    Online Resource
    Online Resource
    A multicenter phase II study on the efficacy and safety of hetrombopag in patients with severe aplastic anemia refractory to immunosuppressive therapy
    SAGE Publications ; 2022
    In:  Therapeutic Advances in Hematology Vol. 13 ( 2022-01), p. 204062072210851-
    Details
    In: Therapeutic Advances in Hematology, SAGE Publications, Vol. 13 ( 2022-01), p. 204062072210851-
    Abstract: In this single-arm phase II study (NCT03557099), we evaluated the efficacy and safety of hetrombopag, a small molecule thrombopoietin (TPO) receptor agonist, in patients with severe aplastic anemia (SAA) who were refractory to standard first-line immunosuppressive therapy (IST). Methods: SAA patients who were refractory to standard first-line IST were given hetrombopag orally at an initial dose of 7.5 mg once daily to a maximum of 15 mg once daily, for a total of 52 weeks. The primary endpoint was proportion of patients achieving hematologic responses in ⩾1 lineage at week 18. Results: A total of 55 eligible patients were enrolled and received hetrombopag treatment. This study met its primary endpoint, with 23 [41.8%, 95% confidence interval (CI) = 28.7–55.9] patients achieving hematologic response in ⩾1 lineage at week 18 after initiation of hetrombopag treatment. Twenty-four (43.6%, 95% CI = 30.3–57.7) and 27 (49.1%, 95% CI = 35.4–62.9) of the 55 patients responded in ⩾1 lineage at weeks 24 and 52, respectively. Median time to initial hematologic response was 7.9 weeks (range = 2.0–32.1). The responses were durable, with a 12-month relapse-free survival rate of 82.2% (95% CI = 62.2–92.2). Adverse events occurred in 54 (98.2%) patients, and 28 (50.9%) patients had treatment-related adverse events. Seventeen (30.9%) patients had adverse events of grade ⩾3. Serious adverse events occurred in 15 (27.3%) patients and three deaths (5.5%) were reported. Conclusion: Hetrombopag showed encouraging efficacy with durable hematologic responses in patients with SAA who were refractory to IST. Hetrombopag was well tolerant and safe for long-term use. ClinicalTrials.gov identifier: NCT03557099
    Type of Medium: Online Resource
    ISSN: 2040-6207 , 2040-6215
    URL: Article
    DOI: 10.1177/20406207221085197
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2585183-4
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  • 2
    Online Resource
    Online Resource
    User testing of the psychometric properties of pictorial-based disability assessment Longshi Scale by healthcare professionals and non-professionals: a Chinese study in Shenzhen
    SAGE Publications ; 2019
    In:  Clinical Rehabilitation Vol. 33, No. 9 ( 2019-09), p. 1479-1491
    Details
    In: Clinical Rehabilitation, SAGE Publications, Vol. 33, No. 9 ( 2019-09), p. 1479-1491
    Abstract: The aim of this study was to validate a novel pictorial-based Longshi Scale for evaluating a patient’s disability by healthcare professionals and non-professionals. Design: Prospective study. Setting: Rehabilitation departments from a grade A, class 3 public hospital, a grade B, class 2 public hospital, and a private hospital and seven community rehabilitation centers. Subjects: A total of 618 patients and 251 patients with functional disabilities were recruited in a two-phase study, respectively. Main measures: Outcome measure: pictorial scale of activities of daily living (ADLs, Longshi Scale). Reference measure: Barthel Index. The Spearman correlation coefficient was used to analyze the validity of Longshi Scale against Barthel Index. Results: In phase 1 study, from March 2016 to August 2016, the results demonstrated that the Longshi Scale was both reliable and valid (intraclass correlation coefficient based on two-way random effect (ICC 2,1 ) = 0.877–0.974 for intra-rater reliability; ICC 2,1 = 0.928–0.979; κ = 0.679–1.000 for inter-rater reliability; intraclass correlation coefficient based on one-way random effect (ICC 1,1 ) = 0.921–0.984 for test–retest reliability and Spearman correlation coefficient = 0.836–0.899). In the second phase, in March 2018, results further demonstrated that the Longshi Scale had good inter-rater and intra-rater reliability among healthcare professionals and non-professionals including therapists, interns, and personal care aids (ICC 1,1 = 0.822–0.882 on Day 1; ICC 1,1 = 0.842–0.899 on Day 7 for inter-rater reliability). In addition, the Longshi Scale decreased assessment time significantly, compared with the Barthel Index assessment ( P 〈 0.01). Conclusion: The Longshi Scale could potentially provide an efficient way for healthcare professionals and non-professionals who may have minimal training to assess the ADLs of functionally disabled patients.
    Type of Medium: Online Resource
    ISSN: 0269-2155 , 1477-0873
    URL: Article
    DOI: 10.1177/0269215519846543
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2028323-4
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  • 3
    Online Resource
    Online Resource
    Study on the effect of Periplaneta americana on ulcerative colitis in rats induced by 2,4,6-trinitrobenzene sulfonic acid
    SAGE Publications ; 2020
    In:  European Journal of Inflammation Vol. 18 ( 2020-01), p. 205873922094262-
    Details
    In: European Journal of Inflammation, SAGE Publications, Vol. 18 ( 2020-01), p. 205873922094262-
    Abstract: Ulcerative colitis (UC) is a chronic inflammatory disease of intestinal tract, and Periplaneta americana has been found to be effective in the treatment for UC. The purpose of the study was to investigate the therapeutic effect of Periplaneta americana extract Ento-A on UC in rats induced by 2,4,6-trinitrobenzene sulfonic acid (TNBS) and to explore its mechanism. The Sprague-Dawley (SD) rats were randomly divided into normal control group; TNBS-treated group; sulfasalazine (SASP) treated group; Ento-A low- (50 mg/kg), medium- (100 mg/kg), and high-dose (200 mg/kg) groups, respectively. The UC model of rats was induced via TNBS. Disease activity index (DAI) was used to evaluate the severity of UC in rats. The macroscopic and microscopic damages of colon were accessed by colon mucosa damage index (CMDI) and histopathological score (HS), respectively. The levels of interleukin-4 (IL-4), interleukin-17 (IL-17), tumor necrosis factor-α (TNF-α), and interferon-γ (IFN-γ) in serum and the contents of myeloperoxidase (MPO), transforming growth factor-β1 (TGF-β1), and epidermal growth factor (EGF) in colonic mucosa were measured by enzyme-linked immunosorbent assay (ELISA). Compared with the normal control group, the TNBS-treated group showed increase in DAI, CMDI, HS, IL-17, TNF-α, IFN-γ as well as MPO and decrease in the levels of IL-4, EGF, and TGF-β1. However, Ento-A-administrated groups reversed the changes in the DAI, CMDI, HS, and the cytokines caused by TNBS. The study indicates that Periplaneta americana extract Ento-A can effectively alleviate the inflammation in TNBS-induced UC of rats, and the mechanism of that may be related to restoring the balance of T helper 1 (Th1)/Th2/Th17/T regulatory (Treg) cytokines.
    Type of Medium: Online Resource
    ISSN: 2058-7392 , 2058-7392
    URL: Article
    DOI: 10.1177/2058739220942629
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2584683-8
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  • 4
    Online Resource
    Online Resource
    DEVT: A randomized, controlled, multicenter trial of direct endovascular treatment versus standard bridging therapy for acute stroke patients with large vessel occlusion in the anterior circulation – Protocol
    SAGE Publications ; 2021
    In:  International Journal of Stroke Vol. 16, No. 2 ( 2021-02), p. 229-235
    Details
    In: International Journal of Stroke, SAGE Publications, Vol. 16, No. 2 ( 2021-02), p. 229-235
    Abstract: Eight randomized controlled trials have consistently shown that endovascular treatment plus best medical treatment improves outcome after acute anterior proximal intracranial large vessel occlusion strokes. Whether intravenous thrombolysis prior to endovascular treatment in patients with anterior circulation, large vessel occlusion is of any additional benefits remains unclear. Objective This study compares the safety and efficacy of direct endovascular treatment versus intravenous recombinant tissue-type plasminogen activator bridging with endovascular treatment (bridging therapy) in acute stroke patients with intracranial internal carotid artery or middle cerebral artery-M1 occlusion within 4.5 h of symptom onset. Methods and design The DEVT study is a randomized, controlled, multicenter trial with blinded outcome assessment. This trial uses a five-look group-sequential non-inferiority design. Up to 194 patients in each interim analysis will be consecutively randomized to direct endovascular treatment or bridging therapy group in 1:1 ratio over three years from about 30 hospitals in China. Outcomes The primary end-point is the proportion of independent neurological function defined as modified Rankin scale score of 0 to 2 at 90 days. The primary safety measure is symptomatic intracerebral hemorrhage at 48 h and mortality at 90 days. Trial registry number ChiCTR-IOR-17013568 ( www.chictr.org.cn ).
    Type of Medium: Online Resource
    ISSN: 1747-4930 , 1747-4949
    URL: Article
    DOI: 10.1177/1747493020925349
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2211666-7
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  • 5
    Online Resource
    Online Resource
    Nine Novel PAX9 Mutations and a Distinct Tooth Agenesis Genotype-Phenotype
    SAGE Publications ; 2018
    In:  Journal of Dental Research Vol. 97, No. 2 ( 2018-02), p. 155-162
    Details
    In: Journal of Dental Research, SAGE Publications, Vol. 97, No. 2 ( 2018-02), p. 155-162
    Abstract: Tooth agenesis is one of the most common developmental anomalies affecting function and esthetics. The paired-domain transcription factor, Pax9, is critical for patterning and morphogenesis of tooth and taste buds. Mutations of PAX9 have been identified in patients with tooth agenesis. Despite significant progress in the genetics of tooth agenesis, many gaps in knowledge exist in refining the genotype-phenotype correlation between PAX9 and tooth agenesis. In the present study, we complete genetic and phenotypic characterization of multiplex Chinese families with nonsyndromic (NS) tooth agenesis. Direct sequencing of polymerase chain reaction products revealed 9 novel (c.140G 〉 C, c.167T 〉 A, c.332G 〉 C, c.194C 〉 A, c.271A 〉 T, c.146delC, c.185_189dup, c.256_262dup, and c.592delG) and 2 known heterozygous mutations in the PAX9 gene among 120 probands. Subsequently, pedigrees were extended, and we confirmed that the mutations co-segregated with the tooth agenesis phenotype (with exception of families in which DNA analysis was not available). In 1 family ( n = 6), 2 individuals harbored both the PAX9 c.592delG mutation and a heterozygous missense mutation (c.739C 〉 T) in the MSX1 gene. Clinical characterization of families segregating a PAX9 mutation reveal that all affected individuals were missing the mandibular second molar and their maxillary central incisors are most susceptible to microdontia. A significant reduction of bitter taste perception was documented in individuals harboring PAX9 mutations ( n = 3). Functional studies revealed that PAX9 haploinsufficiency or a loss of function of the PAX9 protein underlies tooth agenesis.
    Type of Medium: Online Resource
    ISSN: 0022-0345 , 1544-0591
    URL: Article
    DOI: 10.1177/0022034517729322
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 2057074-0
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  • 6
    Online Resource
    Online Resource
    Humic acid characterization and heavy metal behaviour during vermicomposting of pig manure amended with 13 C-labelled rice straw
    SAGE Publications ; 2022
    In:  Waste Management & Research: The Journal for a Sustainable Circular Economy Vol. 40, No. 6 ( 2022-06), p. 736-744
    Details
    In: Waste Management & Research: The Journal for a Sustainable Circular Economy, SAGE Publications, Vol. 40, No. 6 ( 2022-06), p. 736-744
    Abstract: Aiming to reveal the humification process of organic waste and its contribution to the heavy metal behaviour affected by earthworm activity, it was studied about the variation of humic acid (HA) and heavy metal behaviour during vermicomposting of the mixed pig manure and 13 C-labelled rice straw. The results showed that earthworms could well adapt to the culturing environment and feed organic matter for its growth and reproduction, the vermicomposting process increased the content of humic substances (HS), HA, and fulvic acid (FA) in substrate residues, but led to less transformation of HA into FA. The elemental, ultraviolet absorption spectroscopy, Fourier transform infrared (FTIR) and fluorescence excitation–emission matrix (EEM) analysis indicated that vermicomposting led to more aromatic structures and much higher humification degree in HA, whereas less protein, FA-like substances and plastein in HA. Vermicomposting could enhance the total Cu content and decrease Cu/Zn bioavailability in the substrate residues, and vermicomposting especially can help stabilize Cu in the substrate residues by forming more complexed HA–Cu.
    Type of Medium: Online Resource
    ISSN: 0734-242X , 1096-3669
    URL: Article
    DOI: 10.1177/0734242X211035943
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2022
    detail.hit.zdb_id: 1480483-9
    detail.hit.zdb_id: 46937-3
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  • 7
    Online Resource
    Online Resource
    Study on novel signal processing and simultaneous-fault diagnostic method for wind turbine
    SAGE Publications ; 2019
    In:  Transactions of the Institute of Measurement and Control Vol. 41, No. 14 ( 2019-10), p. 4100-4113
    Details
    In: Transactions of the Institute of Measurement and Control, SAGE Publications, Vol. 41, No. 14 ( 2019-10), p. 4100-4113
    Abstract: High-precision fault diagnosis is important for the widely installed complex industrial product, the wind turbine. However, intelligent monitoring is difficult due to the fuzzy boundaries and individual different variations of the unseen single or simultaneous-fault of such intricate equipment. To solve this problem, this study proposes an ensemble fault diagnostic framework for simultaneous and coupling failure. First, this paper develops novel signal processing methods for effective feature learning and mapping from the non-stationary and nonlinear raw vibrational signals. The adapted variational mode decomposition is introduced based on the particle swarm optimization that applies the minimum mean envelope entropy to optimize the parameters settings. Second, the novel ensemble extreme learning machine-based network is proposed to isolate the faults that applies one extreme learning machine network to count the number of fault scenarios, and the other one to identify the specific single or simultaneous-fault labels. With this scheme, the self-adaptive ensemble extreme learning machine-based fault diagnostic framework is more accurate and faster than the prevailing probabilistic classifier-based methods, as the proposed method does not rely on empirically specified decision-making threshold and generates all the candidate fault labels at the same time. Finally, this study builds the test platform and compares the overall results with the existing feature analysis methods and classifiers. The experimental results verify that the proposed framework detects both single and simultaneous-fault accurately and quickly.
    Type of Medium: Online Resource
    ISSN: 0142-3312 , 1477-0369
    URL: Article
    DOI: 10.1177/0142331219849261
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2025882-3
    SSG: 3,2
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  • 8
    Online Resource
    Online Resource
    Multiple osteolytic primary peripheral T-cell bone lymphoma: the first case report
    SAGE Publications ; 2021
    In:  Journal of International Medical Research Vol. 49, No. 10 ( 2021-10), p. 030006052110522-
    Details
    In: Journal of International Medical Research, SAGE Publications, Vol. 49, No. 10 ( 2021-10), p. 030006052110522-
    Abstract: Peripheral T-cell lymphoma accounts for about 10% of all cases of non-Hodgkin’s lymphoma. However, less than 5% of patients with non-Hodgkin’s lymphoma present with hypercalcaemia as the initial symptom, and less than 1% present with primary bone lesions. We herein describe a 76-year-old Chinese man who was diagnosed with primary bone adult T-cell lymphoma with extensive osteolysis, including bone loss in the radius, as the initial manifestation. He had developed severe generalised bone pain and an inability to raise his arms. X-ray examination revealed osteolytic destruction of the forearm with loss of the radial diaphysis. The patient was diagnosed with peripheral T-cell lymphoma based on his immunohistochemical results. He began treatment with the CHOPE chemotherapy regimen, which resulted in significant improvement of his bone pain.
    Type of Medium: Online Resource
    ISSN: 0300-0605 , 1473-2300
    URL: Article
    DOI: 10.1177/03000605211052229
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2082422-1
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  • 9
    Online Resource
    Online Resource
    Design and experimental study of ginkgo leaf picking device
    SAGE Publications ; 2021
    In:  Proceedings of the Institution of Mechanical Engineers, Part C: Journal of Mechanical Engineering Science Vol. 235, No. 24 ( 2021-12), p. 7353-7362
    Details
    In: Proceedings of the Institution of Mechanical Engineers, Part C: Journal of Mechanical Engineering Science, SAGE Publications, Vol. 235, No. 24 ( 2021-12), p. 7353-7362
    Abstract: To achieve the purpose of Ginkgo biloba leaves continuous harvesting, a ginkgo leaf picking device is designed. The device is consisted of a picking executive composed from a round rod picking hand and a rotating drum, a frame, a motor, a motor base, a coupling, a bearing seat, a motor support frame, a deciduous box, and a connecting screw. And the picking theoretical analysis and calculation are carried out. Finally, the feasibility of the design is verified by adjusting the tilt angle and motor speed of the picking device. The experimental results show that when the inclination angle between the picking device and the horizontal plane is 30° and the motor speed is 120 r/min, the damage rate of Ginkgo biloba leaves is 1.52%. The net collection rate is 94.29%, and the damage degree of branch and stem is mild.
    Type of Medium: Online Resource
    ISSN: 0954-4062 , 2041-2983
    URL: Article
    DOI: 10.1177/09544062211023118
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2024890-8
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  • 10
    Online Resource
    Online Resource
    Association of UGT2B7 polymorphisms with risk of induced liver injury by anti-tuberculosis drugs in Chinese Han
    SAGE Publications ; 2017
    In:  International Journal of Immunopathology and Pharmacology Vol. 30, No. 4 ( 2017-12), p. 434-438
    Details
    In: International Journal of Immunopathology and Pharmacology, SAGE Publications, Vol. 30, No. 4 ( 2017-12), p. 434-438
    Abstract: Anti-tuberculosis drug-induced liver injury (ATLI) is common during the treatment of tuberculosis (TB). As an important enzyme in the metabolism of many drugs, UGT2B7 (uridine diphosphate glucuronyl transferase 2B7) was associated with drug-induced liver disorder. This study investigated the association between the polymorphisms of UGT2B7 and ATLI in Chinese Han. Totally, 280 newly diagnosed TB patients had been followed up for 3 months after the prescription of anti-TB therapy. Tag-single-nucleotide polymorphism (tag-SNPs) (rs10028494 and rs7668282) were genotyped with the MassARRAY platform. The associations between tag-SNPs and ATLI risk were analyzed by logistic regression analysis adjusting for confounding factors. In this prospective study, 33 patients were lost to follow-up, and 24 patients were diagnosed with ATLI and considered as the case group. The remaining 223 subjects without ATLI were considered as the control group. No significant association was observed in allele and genotype frequencies of UGT2B7 between the two groups. This study is the first attempt to investigate the association of genetic polymorphisms of UGT2B7 with ATLI in Chinese Han. There is no significant association between UGT2B7 polymorphisms and ATLI in Chinese Han.
    Type of Medium: Online Resource
    ISSN: 2058-7384 , 2058-7384
    URL: Article
    DOI: 10.1177/0394632017733638
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2017
    detail.hit.zdb_id: 2505963-4
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