In:
Journal of Scleroderma and Related Disorders, SAGE Publications, Vol. 8, No. 1 ( 2023-02), p. 79-84
Abstract:
This case–control study analyzed risk factors for symptomatic fractures in a group of 52 patients with systemic sclerosis compared with a group of 104 patients without fractures, matched for sex and age, who were attended at a single systemic sclerosis outpatient clinic from 2010 to 2020. Fractures affected predominantly vertebral (65.4%), rib (13.5%), and hip (7.7%) joints, while the mean age of fracture was 55.3 ± 9.5 years. Age at disease onset, age at diagnosis, disease duration, age at menarche, and age at menopause were similar in both groups, and 58.9% of the patients were menopausal at the time of the fracture. The presence of fractures had a significant association with densitometric osteoporosis (p 〈 0.001), lower weight (p = 0.032), and bone mineral index (p = 0.044), anti-RNA polymerase III (p = 0.040), use of corticosteroids (p = 0.019), and bisphosphonates (p 〈 0.001), as well as with densitometric T-scores of lumbar spine (p 〈 0.001), femoral neck (p = 0.025), and total hip (p = 0.013). Multivariate analysis showed that the variables significantly associated with fractures were high doses of corticosteroids (odds ratio = 4.10; 95% confidence interval = 1.290–13.090; p = 0.017), bisphosphonates (odds ratio = 3.91; 95% confidence interval = 1.699–8.984; p = 0.001), negative anti-Scl70 (OR = 0.34; 95% confidence interval = 0.124–0.943; p = 0.038), and lumbar T-score (odds ratio = 0.39; 95% confidence interval = 0.034–0.460; p = 0.010). In conclusion, symptomatic fractures were associated predominantly with lower bone mineral density of lumbar spine and use of high doses of corticosteroids and bisphosphonates in this cohort.
Type of Medium:
Online Resource
ISSN:
2397-1983
,
2397-1991
DOI:
10.1177/23971983221141271
Language:
English
Publisher:
SAGE Publications
Publication Date:
2023
detail.hit.zdb_id:
2964332-6
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