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  • 1
    Online Resource
    Online Resource
    SAGE Publications ; 2023
    In:  Personality and Social Psychology Bulletin Vol. 49, No. 5 ( 2023-05), p. 727-743
    In: Personality and Social Psychology Bulletin, SAGE Publications, Vol. 49, No. 5 ( 2023-05), p. 727-743
    Abstract: Two studies were conducted to further the understanding of daily experiences of perseverance and passion and the influences of personality traits (e.g., grit and conscientiousness) and contextual factors. Study 1 applied the experience sampling method ( n = 116; observations = 5,187) and found that perseverance of effort (PE) predicted passion when controlling for conscientiousness. Study 2 used the day reconstruction method ( n = 468; observations = 1,872) and found that both PE and consistency of interest (CI) had effects, although CI was a stronger predictor than PE. In both studies, PE was moderated only by instrumentality of the activity, whereas CI was moderated only by perceived difficulty. We also found mediating effects of instrumentality, (lower) perceived difficulty, and (fewer) intrusive thoughts on the pathways between traits and perseverance and passion. These results deepen our knowledge on why and how perseverance-related traits impact daily experiences of perseverance and passion.
    Type of Medium: Online Resource
    ISSN: 0146-1672 , 1552-7433
    RVK:
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2047603-6
    SSG: 5,2
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  • 2
    Online Resource
    Online Resource
    SAGE Publications ; 2013
    In:  Energy Exploration & Exploitation Vol. 31, No. 2 ( 2013-03), p. 317-335
    In: Energy Exploration & Exploitation, SAGE Publications, Vol. 31, No. 2 ( 2013-03), p. 317-335
    Abstract: China is rapidly advancing both theoretical research and practical exploration of her shale gas deposits. Shale gas deposits in China span the gamut of the basic geological features e.g.: marine facies, marine-continental transitional facies, continental facies, and many strata covering the Palaeozoic, Mesozoic, and Cenozoic. Lacustrine shale contained abundant organic matter is mainly developed in the Mesozoic-Cenozoic and is distributed across the North of China, with local occurrences in southern regions. The deposits are characterised by thin monolayer thickness, many inter-beds, large total thickness, rapid lateral variation, varied organic matter types, and a low degree of thermal evolution. The favourable conditions for forming the shale gas enrichment of China's lacustrine organic rich shale mainly include: abundant reservoir porosity, varied organic matter types, large total thickness, good preservation conditions, resource abundance, and favourable surface conditions; the unfavourable conditions mainly include: poor areal continuity, sudden changes in cross-section, and relatively low maturity. At present, continental shale gas exploration of Triassic deposits in the Ordos basin and Jurassic deposits in the Sichuan basin have made significant breakthroughs. Based on the present state of China's shale gas exploration and development, combined with investigation and evaluation, the work demands favourable zone optimisation for China's shale gas resource potential to be best exploited. Shale gas enrichment is considered, not only through determination of the resource's physical boundary with many types and complex geological conditions pertaining to shale gas in China, but in combination with the paucity of shale gas exploration-related geological data and paucity of geological knowledge: the relevant computation parameters are difficult to ascertain accurately, thus the probability volume method is used to evaluate potential continental shale gas strata, including Triassic, Jurassic, Cretaceous and Palaeogene deposits in northern, and north-eastern China, Triassic, Jurassic, Cretaceous, and Palaeogene deposits in northwest regions, some Permian deposits, Jurassic deposits from the upper Yangtze and Dian Qian-Gui(Yunnan-Guizhou-Guangxi) regions, and Jurassic and Palaeogene deposits from the middle-lower Yangtze and southeast region. Estimated continental shale gas resources recoverable in China are 7.92×10 12 m 3 , which accounts for 31.59% of her total shale gas recoverable resources. Among them, continental exploitable resource potential is greatest in northern, and northeast regions of China ( c. 3×10 12 m 3 , some 37.75% of the total shale gas resource recoverable), followed by the northwest region, the upper Yangtze and Dian-Qian-Gui regions, the middle-lower Yangtze, and the southeast region. Geological resources, and recoverable resources, of Jurassic continental shale gas are the largest ( c. 3.77×10 12 m 3 , some 47.6% of the total continental shale gas resource recoverable), followed by Cretaceous, Palaeogene, Triassic, and Permian deposits.
    Type of Medium: Online Resource
    ISSN: 0144-5987 , 2048-4054
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2013
    detail.hit.zdb_id: 2026571-2
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  • 3
    In: Journal of Cardiovascular Pharmacology and Therapeutics, SAGE Publications, Vol. 21, No. 1 ( 2016-01), p. 82-92
    Abstract: The development of diabetic macrovascular complications is a multifactorial process, and melatonin may possess cardiovascular protective properties. This study was designed to evaluate whether melatonin attenuates arteriosclerosis and endothelial permeability by suppressing the myosin light-chain kinase (MLCK)/myosin light-chain phosphorylation (p-MLC) system via the mitogen-activated protein kinase (MAPK) signaling pathway or by suppressing the myosin phosphatase-targeting subunit phosphorylation (p-MYPT)/p-MLC system in diabetes mellitus (DM). Rats were randomly divided into 4 groups, including control, high-fat diet, DM, and DM + melatonin groups. Melatonin was administered (10 mg/kg/d) by gavage for 12 weeks. The DM significantly increased the serum fasting blood glucose and lipid levels, as well as insulin resistance and endothelial dysfunction, which were attenuated by melatonin therapy to various extents. Importantly, the aortic endothelial permeability was significantly increased in DM rats but was dramatically reversed following treatment with melatonin. Our findings further indicated that hyperglycemia and hyperlipidemia enhanced the expressions of MLCK, p-MYPT, and p-MLC, which were partly associated with decreased membrane type 1 expression, increased extracellular signal-regulated kinase (ERK) phosphorylation, and increased p38 expression. However, these changes in protein expression were also significantly reversed by melatonin. Thus, our results are the first to demonstrate that the endothelial hyperpermeability induced by DM is associated with increased expressions of MLCK, p-MYPT, and p-MLC, which can be attenuated by melatonin at least partly through the ERK/p38 signaling pathway.
    Type of Medium: Online Resource
    ISSN: 1074-2484 , 1940-4034
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2016
    detail.hit.zdb_id: 2230155-0
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  • 4
    Online Resource
    Online Resource
    SAGE Publications ; 2021
    In:  Experimental Biology and Medicine Vol. 246, No. 11 ( 2021-06), p. 1330-1341
    In: Experimental Biology and Medicine, SAGE Publications, Vol. 246, No. 11 ( 2021-06), p. 1330-1341
    Abstract: GM1 gangliosidosis is a rare lysosomal storage disease caused by a deficiency of β-galactosidase due to mutations in the GLB1 gene. We established a C57BL/6 mouse model with Glb1 G455R mutation using CRISPR/Cas9 genome editing. The β-galactosidase enzyme activity of Glb1 G455R mice measured by fluorometric assay was negligible throughout the whole body. Mutant mice displayed no marked phenotype at eight weeks. After 16 weeks, GM1 ganglioside accumulation in the brain of mutant mice was observed by immunohistochemical staining. Meanwhile, a declining performance in behavioral tests was observed among mutant mice from 16 to 32 weeks. As the disease progressed, the neurological symptoms of mutant mice worsened, and they then succumbed to the disease by 47 weeks of age. We also observed microglia activation and proliferation in the cerebral cortex of mutant mice at 16 and 32 weeks. In these activated microglia, the level of autophagy regulator LC3 was up-regulated but the mRNA level of LC3 was normal. In conclusion, we developed a novel murine model that mimicked the chronic phenotype of human GM1. This Glb1 G455R murine model is a practical in vivo model for studying the pathogenesis of GM1 gangliosidosis and exploring potential therapies.
    Type of Medium: Online Resource
    ISSN: 1535-3702 , 1535-3699
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2021
    detail.hit.zdb_id: 2020856-X
    SSG: 12
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  • 5
    Online Resource
    Online Resource
    SAGE Publications ; 2019
    In:  Cell Transplantation Vol. 28, No. 6 ( 2019-06), p. 747-755
    In: Cell Transplantation, SAGE Publications, Vol. 28, No. 6 ( 2019-06), p. 747-755
    Abstract: Induced pluripotent stem cells (iPS cells) are promising cell source for stem cell replacement strategy applied to brain injury caused by traumatic brain injury (TBI) or stroke. Neural stem cell (NSCs) derived from iPS cells could aid the reconstruction of brain tissue and the restoration of brain function. However, tracing the fate of iPS cells in the host brain is still a challenge. In our study, iPS cells were derived from skin fibroblasts using the four classic factors Oct4, Sox2, Myc, and Klf4. These iPS cells were then induced to differentiate into NSCs, which were incubated with superparamagnetic iron oxides (SPIOs) in vitro. Next, 30 TBI rat models were prepared and divided into three groups ( n = 10). One week after brain injury, group A & B rats received implantation of NSCs (labeled with SPIOs), while group C rats received implantation of non-labeled NSCs. After cell implantation, all rats underwent T2*-weighted magnetic resonance imaging (MRI) scan at day 1, and 1 week to 4 weeks, to track the distribution of NSCs in rats’ brains. One month after cell implantation, manganese-enhanced MRI (ME-MRI) scan was performed for all rats. In group B, diltiazem was infused during the ME-MRI scan period. We found that (1) iPS cells were successfully derived from skin fibroblasts using the four classic factors Oct4, Sox2, Myc, and Klf4, expressing typical antigens including SSEA4, Oct4, Sox2, and Nanog; (2) iPS cells were induced to differentiate into NSCs, which could express Nestin and differentiate into neural cells and glial cells; (3) NSCs were incubated with SPIOs overnight, and Prussian blue staining showed intracellular particles; (4) after cell implantation, T2*-weighted MRI scan showed these implanted NSCs could migrate to the injury area in chronological order; (5) the subsequent ME-MRI scan detected NSCs function, which could be blocked by diltiazem. In conclusion, using an in vivo MRI tracking technique to trace the fate of iPS cells-induced NSCs in host brain is feasible.
    Type of Medium: Online Resource
    ISSN: 0963-6897 , 1555-3892
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2020466-8
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  • 6
    In: Angiology, SAGE Publications, Vol. 60, No. 2 ( 2009-04), p. 180-185
    Abstract: Interleukin 18 (IL–18) is a pro-atherogenic cytokine associated with the occurrence of various cardiac complications. The IL–18 gene has a functional −137 G/C polymorphism (rs187238) in the promoter region. Using the ligase detection reaction-polymerase chain reaction, we genotyped a cohort of patients in Chinese Han population in Xiangfan region. Case patients of coronary artery disease and control patients were identified by coronary angiography. The plasma IL–18 concentrations were measured by ELISA. A significant increase of G allele or GG-genotype was observed in 241 case patients compared to 145 control individuals (frequency of G allele = 0.90 vs 0.83, p=0.004; frequency of GG-genotype = 0.81 vs 0.68, p = 0.005). In case patients, G allele carriers in multi-vessel disease patients had a higher occurrence rate when compared to single-vessel disease patients, but no significant difference was detected (frequency of G allele = 0.92 vs 0.88, p=0.107; frequency of GG-genotype = 0.84 vs 0.75, p = 0.089). IL–18 protein concentration of the −137GG genotype was much higher than concentration of the CG and CC genotype (case patients: 229.1±131.5 vs 122.7±73.6 pg/ml, P 〈 0.001; control patients: 65.9±31.6 vs 42.4±19.5 pg/ml, P 〈 0.001). To conclude, IL–18 promoter −137G/C polymorphism influences IL–18 levels and the occurrence of coronary artery disease, suggesting that IL–18 is causally involved in the development of atherosclerosis.
    Type of Medium: Online Resource
    ISSN: 0003-3197 , 1940-1574
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2009
    detail.hit.zdb_id: 2065911-8
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  • 7
    In: International Journal of Stroke, SAGE Publications, Vol. 18, No. 1 ( 2023-01), p. 95-101
    Abstract: Early neurological deterioration (END) is not a rare phenomenon in single subcortical infarction (SSI; traditionally known as lacunar infarction) patients. Predictors of END in SSI patients are uncertain. Aims: We aimed to investigate the association between infarct lesion characteristics, penetrating artery morphology, carrier artery plaque features and END using whole-brain vessel-wall imaging. Methods: We prospectively collected data from SSI patients without stenosis of the corresponding carrier artery. The infarct lesion size and location, lenticulostriate artery (LSA) morphological characteristics, and features of the middle cerebral artery (MCA) plaques involving M1 segment adjacent to LSA origin on the symptomatic side were compared between patients with or without END. Results: A total of 74 participants were enrolled, of whom 23 cases (31.1%) showed END. Multivariable logistic regression analysis adjusted for baseline National Institutes of Health Stroke Scale score and axial maximal diameter of infarct lesion revealed that the patients with MCA plaques adjacent to the LSA origin were more likely to develop END (odds ratio (OR) = 3.87, 95% confidence interval (CI) = 1.21–12.33), while with longer average length of LSAs were less likely to occur END (OR = 0.21, 95% CI = 0.05–0.92). Conclusion: MCA plaques located adjacent to the LSA origin and average length of LSAs on the symptomatic side were independent predictors of END in SSI patients. This finding might provide new insights into the mechanisms of the neurological progression in SSI and facilitate therapeutic interventions.
    Type of Medium: Online Resource
    ISSN: 1747-4930 , 1747-4949
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2211666-7
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  • 8
    In: Technology in Cancer Research & Treatment, SAGE Publications, Vol. 22 ( 2023-01)
    Abstract: Objectives: To investigate the dosimetric advantages of the voluntary deep inspiration breath-hold technique assisted by optical surface monitoring system for whole breast irradiation in left breast cancer after breast-conserving surgery and verify the reproducibility and acceptability of this technique. Methods: Twenty patients with left breast cancer receiving whole breast irradiation after breast-conserving surgery were enrolled in this prospective phase II study. Computed tomography simulation was performed during both free breathing and voluntary deep inspiration breath-hold for all patients. Whole breast irradiation plans were designed, and the volumes and doses of the heart, left anterior descending coronary artery, and lung were compared between free breathing and voluntary deep inspiration breath-hold. Cone beam computed tomography was performed for the first 3 treatments, then weekly during voluntary deep inspiration breath-hold treatment to evaluate the accuracy of the optical surface monitoring system technique. The acceptance of this technique was evaluated with in-house questionnaires completed by patients and radiotherapists. Results: The median age was 45 (27-63) years. All patients received hypofractionated whole breast irradiation using intensity-modulated radiation therapy up to a total dose of 43.5 Gy/2.9 Gy/15f. Seventeen of the 20 patients received concomitant tumor bed boost to a total dose of 49.5 Gy/3.3 Gy/15f. Voluntary deep inspiration breath-hold showed a significant decrease in the heart mean dose (262 ± 163 cGy vs 515 ± 216 cGy, P  〈  .001) and left anterior descending coronary artery (1191 ± 827 cGy vs 1794 ± 833 cGy, P  〈  .001). The median delivery time of radiotherapy was 4 (1.5-11) min. The median deep breathing cycles were 4 (2-9) times. The average score for acceptance of voluntary deep inspiration breath-hold by patients and radiotherapists was 8.7 ± 0.9 (out of 12) and 10.6 ± 3.2 (out of 15), respectively, indicating good acceptance by both. Conclusions: The voluntary deep inspiration breath-hold technique for whole breast irradiation after breast-conserving surgery in patients with left breast cancer significantly reduces the cardiopulmonary dose. Optical surface monitoring system–assisted voluntary deep inspiration breath-hold is reproducible and feasible and showed good acceptance by both patients and radiotherapists.
    Type of Medium: Online Resource
    ISSN: 1533-0346 , 1533-0338
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2023
    detail.hit.zdb_id: 2146365-7
    detail.hit.zdb_id: 2220436-2
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  • 9
    Online Resource
    Online Resource
    SAGE Publications ; 2019
    In:  Dose-Response Vol. 17, No. 4 ( 2019-10-01), p. 155932581988950-
    In: Dose-Response, SAGE Publications, Vol. 17, No. 4 ( 2019-10-01), p. 155932581988950-
    Abstract: Radiation-induced liver damage (RILD) has become a limitation in radiotherapy for hepatocellular carcinoma. We established a rabbit model of RILD by CyberKnife. Electron microscopy analysis revealed obvious nuclear atrophy and disposition of fat in the nucleus after irradiation. We then utilized a mass spectrometry-based label-free relative quantitative proteomics approach to compare global proteomic changes of rabbit liver in response to radiation. In total, 2365 proteins were identified, including 338 proteins that were significantly dysregulated between irradiated and nonirradiated liver tissues. These differentially expressed proteins included USP47, POLR2A, CSTB, MCFD2, and CSNK2A1. Real-time polymerase chain reaction confirmed that USP47 and CABLES1 transcripts were significantly higher in irradiated liver tissues, whereas MCFD2 and CSNK2A1 expressions were significantly reduced. In Clusters of Orthologous Groups of proteins analysis, differentially expressed proteins were annotated and divided into 24 categories, including posttranslational modification, protein turnover, and chaperones. Kyoto Encyclopedia of Genes and Genomes analysis revealed that the enriched pathways in dysregulated proteins included the vascular endothelial growth factors (VEGF) signaling pathway, the mitogen-activated protein kinase (MAPK) signaling pathway, and the adipocytokine signaling pathway. The identification of proteins and pathways is crucial toward elucidating the radiation response process of the liver, which may facilitate the discovery of novel therapeutic targets.
    Type of Medium: Online Resource
    ISSN: 1559-3258 , 1559-3258
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2440820-7
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  • 10
    In: Journal of Cerebral Blood Flow & Metabolism, SAGE Publications, Vol. 37, No. 3 ( 2017-03), p. 837-847
    Abstract: Striatal neurons regulate the activity of neural progenitor cells in the subventricular zone, but the effect of striatal neuronal activity on neurogenesis after ischemic stroke is unclear. In this study, we used optogenetic tools to investigate the impact of striatal neuronal activity on the neurogenesis and functional recovery after cerebral ischemia. We transfected striatal neurons with channelrhodopsin-2 or halorhodopsin from Natronomonas so that they can be excited by 473 nm laser or inhibited by 594 nm laser, respectively. Neural inhibition but not excitation at 4–7 days after middle cerebral artery occlusion resulted in reduced atrophy volume (6.8 ± 0.7 vs 8.5 ± 1.2 mm 3 , p  〈  0.05) and better performance represented by longer sustaining time on rotarod (99.3 ± 9 vs 80.1 ± 11 s, p  〈  0.01) and faster moving speed (7.7 ± 2 vs 5.7 ± 1.1 cm/s, p  〈  0.05) in open field tests. Furthermore, neural inhibition increased the number of nestin + , BrdU + /doublecortin + and BrdU + /NeuN + cells ( p  〈  0.001) in the subventricular zone and peri-focal region, and the expression level of axon guidance factor Netrin-1 (0.39 ± 0.16 vs 0.16 ± 0.02, p  〈  0.05) in the peri-focal region. These data suggest that striatal neuronal activity plays an important role in regulating neurogenesis and neural-behavioral outcomes, and that inhibiting striatal neurons by optogenetics promotes the recovery after ischemic stroke in mice.
    Type of Medium: Online Resource
    ISSN: 0271-678X , 1559-7016
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2017
    detail.hit.zdb_id: 2039456-1
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