In:
BMC Proceedings, Springer Science and Business Media LLC, Vol. 1, No. S1 ( 2007-12)
Abstract:
Heterogeneity poses a challenge to linkage mapping. Here, we apply a latent class extension of Haseman-Elston regression to expression phenotypes with significant evidence of linkage to trans regulators in 14 large pedigrees. We test for linkage, accounting for heterogeneity, and classify individual families as "linked" and "unlinked" on the basis of their contribution to the overall evidence of linkage.
Type of Medium:
Online Resource
ISSN:
1753-6561
DOI:
10.1186/1753-6561-1-S1-S80
Language:
English
Publisher:
Springer Science and Business Media LLC
Publication Date:
2007
detail.hit.zdb_id:
2411867-9
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