In:
Pteridines, Walter de Gruyter GmbH, Vol. 2, No. 1 ( 1990-01), p. 17-21
Abstract:
Urine concentrations of neopterin, a marker for the activation of cellular immunity, were determined concomitantly with a large panel of hematological and immunological variables on 24 women with gynaecological cancers (12 uterine cervix, 5 endometrium, 7 ovary). There were 14 women investigated at first diagnosis of carcinoma, and 10 women were studied during follow-up (evidence of disease, only palliative treatment during the preceding three months). A statistically significant correlation was found between neopterin concentrations and number of circulating non-B lymphocytes expressing HLA-DR antigen. Neopterin concentrations, numbers of HLA-DR positive cells, and numbers of circulating leukocytes were significantly higher in women studied during follow-up, when compared with women freshly diagnosed. In contrast. numbers of CD4 +, CD3 +, CD19 + lymphocytes and of total lymphocytes in peripheral blood were significantly lower in women studied during follow-up. The results suggest that high neopterin levels in tumor patients indicate activation of early steps of cellular immune mechanisms.
Type of Medium:
Online Resource
ISSN:
2195-4720
,
0933-4807
DOI:
10.1515/pteridines.1990.2.1.17
Language:
Unknown
Publisher:
Walter de Gruyter GmbH
Publication Date:
1990
detail.hit.zdb_id:
2279565-0
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