In:
Helvetica Chimica Acta, Wiley, Vol. 102, No. 7 ( 2019-07)
Abstract:
In this article, we report the rapid and facile synthesis of chiral 3‐methyl‐2,5‐ trans ‐tetrahydrofurans. This reaction utilizes cheap and easily available starting materials. A domino hydrolysis and intramolecular Michael ‐type ring closure reaction was the key step. As a result, synthesis of the desired 3‐methyl‐2,5‐ trans ‐tetrahydrofurans could be achieved in gram‐scale over seven linear steps with high chemical yield and high diastereoselectivity.
Type of Medium:
Online Resource
ISSN:
0018-019X
,
1522-2675
DOI:
10.1002/hlca.201900131
Language:
English
Publisher:
Wiley
Publication Date:
2019
detail.hit.zdb_id:
74-7
detail.hit.zdb_id:
1475013-2
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