In:
Head & Neck, Wiley, Vol. 35, No. 10 ( 2013-10), p. 1471-1474
Abstract:
In patients with recurrent and/or metastatic head and neck squamous cell cancer (HNSCC), there are no data about an every‐other‐week cetuximab maintenance schedule after chemotherapy plus cetuximab as first‐line treatment. Methods We reviewed the safety and feasibility of every‐other‐week maintenance cetuximab administered at 3 different European centers. Results Thirty‐one patients with recurrent or metastatic HNSCC were treated from 2006 to 2010. Mean cetuximab dose intensity in the maintenance phase was 93%. The major toxicities reported during every‐other‐week maintenance cetuximab were skin rash (grade 3, 16%; grade 2, 23%), fatigue (grade 3, 3%; grade 2, 16%), diarrhea (grade 3, 7%; grade 2, 13%), hypomagnesemia (grade 4, 3%; grade 3, 3%; grade 2, 19%), and mucositis (grade 3, 3%; grade 2, 23%). Conclusions Every‐other‐week maintenance cetuximab schedule was well tolerated and did not worsen toxicity that occurred during chemotherapy. In daily practice, this simplified schedule could improve compliance and possibly improve quality of life in patients with recurrent or metastatic HNSCC that showed no progression during first‐line chemotherapy. © 2012 Wiley Periodicals, Inc. Head Neck 35: 1471–1474, 2013
Type of Medium:
Online Resource
ISSN:
1043-3074
,
1097-0347
Language:
English
Publisher:
Wiley
Publication Date:
2013
detail.hit.zdb_id:
2001440-5
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