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  • 1
    In: Cancer Reports, Wiley, Vol. 3, No. 5 ( 2020-10)
    Abstract: Drug delivery system is a common practice in cancer treatment. RNA interference‐mediated post‐transcriptional gene silencing holds promise as an approach to knockdown in the expression of target genes responsible for cancer cell growth and metastasis. RNA interference (RNAi) can be achieved by delivering small interfering RNA (siRNA) and short hairpin RNA (shRNA) to target cells. Since neither interfering RNAs can be delivered in naked form due to poor stability, an efficient delivery system is required that protects, guides, and delivers the siRNA and shRNA to target cells as part of cancer therapy (chemotherapy). Recent findings In this review, a discussion is presented about the different types of drug delivery system used to deliver siRNA and shRNA, together with an overview of the potential benefits associated with this sophisticated biomolecular therapy. Improved understanding of the different approaches used in nanoparticle (NP) fabrication, along with an enhanced appreciation of the biochemical properties of siRNA/shRNA, will assist in developing improved drug delivery strategies in basic and clinical research. Conclusion These novel delivery techniques are able to solve the problems that form an inevitable part of delivering genes in more efficient manner and as part of more effective treatment protocols. The present review concludes that the nanoparticulate RNA delivery system has great possibility for cancer treatment along with several other proposed methods. Several NPs or nanocarriers are already in use, but the methods proposed here could fulfill the missing gap in cancer research. It is the future technology, which unravels the mystery of resolving genomic diseases that is, especially genomic instability and its signaling cascades.
    Type of Medium: Online Resource
    ISSN: 2573-8348 , 2573-8348
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2920367-3
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  • 2
    In: Land Degradation & Development, Wiley, Vol. 33, No. 7 ( 2022-04-30), p. 1076-1087
    Abstract: To test the applicability of alternate land use systems for improving soil functionality in restored ecologies, soils were sampled from 0–15, 15–30 and 30–45 cm deep layers of Leucaena leucocephala (LL), Hardwickia binata (HB), Emblica officinalis (EO), Azadiracta indic a (AI)‐based silviculture systems; Acacia nilotica ‐based silvipasture systems (AN); and natural grassland (NG). These were compared with samples from fallow land (F). They were evaluated for their carbon management index (CMI), nutrient supply capacity (NSC), soil functionality (SF), ecorestoration efficiency (ERE) and 21‐day cumulative microbial respiration (CO 2 ‐21) to assess their applicability in semiarid India. Soil functionality and functional diversity as impacted by restoration have remained largely overlooked. The LL had ~12, 7 and 11% higher CMI than fallow in sampled soil layers. ERE of LL was ~ 55, 65 and 79% higher than fallow land in sampled soil layers, respectively. However, ERE in surface layer was poorer than subsequent soil layers for all systems. The LL, HB and AN improved NSC and SF by: a) ~ 2.5‐, 2.2‐ and 1.6‐times; and b) 9.3‐, 5.3‐ and 5.1‐times over fallow land in the surface soil layer. A similar trend was observed for SF in lower layers. However, the topsoil layer had 〉 16% mean SF values than subsequent layers. LL, HB and AN systems had ~4.2‐, 2.3‐ and 1.9‐times higher CO 2 ‐21 than fallow land in the top layer. CO 2 ‐21 was positively correlated with NSC and SF but could not predict ERE well. Hence, legume tree‐based restoration tactics might be useful for improving land restoration and soil functionality in semiarid regions.
    Type of Medium: Online Resource
    ISSN: 1085-3278 , 1099-145X
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2021787-0
    detail.hit.zdb_id: 1319202-4
    SSG: 14
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