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  • 1
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    Semiologic subgroups of insulo‐opercular seizures based on connectional architecture atlas
    Wiley ; 2020
    In:  Epilepsia Vol. 61, No. 5 ( 2020-05), p. 984-994
    Details
    In: Epilepsia, Wiley, Vol. 61, No. 5 ( 2020-05), p. 984-994
    Abstract: Insulo‐opercular seizures are characterized by diverse semiology, related to the insula's multiple functional roles and extensive connectivity. We aimed to identify semiologic subgroups and correlate these with insulo‐opercular subregions based on connectional architecture. Methods We retrospectively collected a large series of 37 patients with insulo‐opercular seizures explored by stereoelectroencephalography (SEEG) from three epilepsy centers. A new human brain atlas (Brainnetome Atlas, BNA) based on both anatomic and functional connections was employed to segment insulo‐opercular cortex. Semiology and SEEG changes were carefully reviewed and quantified. Principal component analysis and cluster analysis were used to correlate semiologic characteristics with insulo‐opercular subregions. Results Four main semiologic subgroups were identified, organized along an anteroventral to posterodorsal axis based on BNA. Group 1 was characterized by epigastric sensation and/or integrated gestural motor behaviors with or without feelings of fear or rage, involving the anteroventral insular regions and mesial temporal lobes. Group 2 was characterized by auditory sensations and symmetric proximal/axial tonic signs involving the posteroventral temporal operculum. The characteristics of group 3 were orofacial and laryngeal signs, involving the intermediate insulo‐opercular regions. The features of group 4 were somatosensory signs followed by nonintegrated gestural motor behaviors and/or asymmetric tonic signs involving the posterodorsal insulo‐opercular regions with propagation to the mesial frontal lobes. Thus anteroventral seizure organizations predominantly showed limbic system semiology, whereas more posterodorsal regions were associated with semiology involving mainly the sensorimotor system. Subjective symptoms proved to be particularly discriminating factors. Significance Insulo‐opercular seizures can be categorized in terms of clinical semiology and correlate with connectional architecture subregions along an anteroventral‐posterodorsal axis in line with the cytoarchitectonic gradient rather than the gyral anatomy of the insula cortex. This provides new insights into facilitating differential diagnosis and presurgical localization but also highlights the importance of considering connectional architecture in determining neural correlates of complex semiologic patterns.
    Type of Medium: Online Resource
    ISSN: 0013-9580 , 1528-1167
    URL: Issue
    URL: Article
    DOI: 10.1111/epi.v61.5
    DOI: 10.1111/epi.16501
    RVK:
    XA 10000
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2002194-X
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  • 2
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    NIR‐Responsive Multifunctional Artificial Skin for Regenerative Wound Healing
    Wiley ; 2024
    In:  Advanced Functional Materials
    Details
    In: Advanced Functional Materials, Wiley
    Abstract: Efficient wound repair with skin appendage regeneration following severe trauma poses a challenge due to the scarcity of skin grafts and decreased drug effectiveness in protease‐rich wound microenvironments. Here, a multifunctional artificial skin (NIR‐mFAS) with photothermal‐triggered drug delivery capabilities is designed to actively and comprehensively improve the regenerative potential of full‐thickness wounds. The antibacterial chitosan/silk fibroin hydrogel matrix of artificial skin, cross‐linked by electrostatic interactions, effectively encapsulates and sustains the release of epidermal growth factor (EGF) to accelerate re‐epithelialization and neovascularization by promoting the migration and proliferation of repair cells. Subsequently, the photothermal responsive polydopamine nanoparticles (PDA‐NPs) dispersed in the matrix enable precise control over the release of BMP4 under the irradiation of 1064 nm NIR, thereby inhibiting scarring by reducing myofibroblasts during the proliferative stage. Importantly, the concurrent controlled release of CHIR99021 can modulate cell fate by inducing the conversion of myofibroblasts into dermal papilla‐like cells, leading to hair follicle and sebaceous gland regeneration. The NIR‐mFAS functions as an advanced delivery system for achieving high‐quality wound healing with appendage regeneration and offers a smart therapeutic approach that can be applied to other treatments requiring coordinated delivery of multiple pharmacological agents.
    Type of Medium: Online Resource
    ISSN: 1616-301X , 1616-3028
    URL: Article
    DOI: 10.1002/adfm.202405876
    Language: English
    Publisher: Wiley
    Publication Date: 2024
    detail.hit.zdb_id: 2029061-5
    detail.hit.zdb_id: 2039420-2
    SSG: 11
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  • 3
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    Effect of Molecular Symmetry on Fused‐Ring Electron Acceptors
    Wiley ; 2022
    In:  Solar RRL Vol. 6, No. 8 ( 2022-08)
    Details
    In: Solar RRL, Wiley, Vol. 6, No. 8 ( 2022-08)
    Abstract: Two isomeric fused‐ring electron acceptors F7TC‐1 and F7TC‐2 with different molecular symmetry are designed and synthesized, and the effect of molecular symmetry is studied. All side chains are located on the same side of the fused‐ring core in axisymmetric F7TC‐1, whereas they are evenly located on both sides of the fused‐ring core in centrosymmetric F7TC‐2. The molecular symmetry shows slight effects on the absorption spectra, energy levels, and bandgaps of the two molecules, but notable effects on crystallinity, molecular packing, film morphology, and device performance. F7TC‐1‐ and F7TC‐2‐based organic solar cells show power conversion efficiencies of 1.08% and 11.14%, respectively. Different molecular packing and film morphology lead to a big difference in device performance.
    Type of Medium: Online Resource
    ISSN: 2367-198X , 2367-198X
    URL: Issue
    URL: Article
    DOI: 10.1002/solr.v6.8
    DOI: 10.1002/solr.202100797
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2882014-9
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  • 4
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    SEEG ‐based reevaluation of epileptogenic networks and the predictive role for reoperation in MTLE patients with surgical failure
    Wiley ; 2023
    In:  Epilepsia Open Vol. 8, No. 3 ( 2023-09), p. 846-857
    Details
    In: Epilepsia Open, Wiley, Vol. 8, No. 3 ( 2023-09), p. 846-857
    Abstract: Approximately 20%–30% of mesial temporal lobe epilepsy (MTLE) patients got unfavorable seizure control after surgery, and there was a discrepancy about the reasons for the surgical failure. The functional connectivity (FC) patterns obtained from stereo‐electroencephalography (SEEG) reveal information about the dynamics of the epileptic brain and the added value of extracting information that was not identifiable in the SEEG data using FC analysis. This study aims to find out the patterns of the potential epileptogenic network of failure patients and the electrophysiological predictors of reoperation. Methods From January 2012 to December 2019, the MTLE patients with surgical failure were reviewed, and all patients underwent SEEG‐guided reoperation. The epileptogenic network was quantified by calculating FC indicators, including phase slope index (PSI), mutual information (MI) strength, imaginary coherence (icoh), and Granger causality. Results Ten patients with 13 seizures were included in the analysis, and 7 of them achieved a favorable outcome after the SEEG‐guided reoperation. The surgical zone (SZ) with a favorable prognosis showed greater outward information flow than the non‐SZ, whereas the SZ with an unfavorable prognosis showed greater inward information flow. The recurrent patients with favorable prognosis had strong connectivity between the posterior hippocampus, temporal neocortex, and insula, whereas the patients with unfavorable prognosis showed strong functional connectivity between the insula and temporal–parietal‐occipital junction. The power spectrum of patients with favorable prognosis was significantly lower than that of patients with unfavorable prognosis, especially showing a more oscillation power of low frequency. Significance The SEEG‐guided reoperation could achieve favorable seizure control outcomes for recurrent patients. The FCs were a potential indicator to help construct the temporal epileptic network and predictor for the reoperative prognosis in the recurrent patients.
    Type of Medium: Online Resource
    ISSN: 2470-9239 , 2470-9239
    URL: Issue
    URL: Article
    DOI: 10.1002/epi4.v8.3
    DOI: 10.1002/epi4.12743
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2863427-5
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  • 5
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    Online Resource
    The Diabetes Risk and Determinants of Transition from Metabolically Healthy to Unhealthy Phenotypes in 49,702 Older Adults: 4‐Year Cohort Study
    Wiley ; 2020
    In:  Obesity Vol. 28, No. 6 ( 2020-06), p. 1141-1148
    Details
    In: Obesity, Wiley, Vol. 28, No. 6 ( 2020-06), p. 1141-1148
    Abstract: This study aimed to assess whether metabolically healthy obesity (MHO) increases the risk of diabetes and to explore how the occurrence of metabolic disorders affects the risk of diabetes and which factors determine metabolic health. Methods This study examined 49,702 older people without diabetes via the Binhai Health Screening Program in Tianjin. Results Compared with individuals with metabolic health and normal weight, the risk of diabetes was increased in older adults with MHO (hazard ratio [HR]: 1.786, 95% CI: 1.407‐2.279) but was not significantly increased when metabolic health was characterized by the absence of metabolic abnormalities. The older adults who were initially affected by MHO and then converted to having an unhealthy phenotype had a higher diabetes risk than older individuals with stable and healthy normal weight (HR: 3.727, 95% CI: 2.721‐5.105). Waist circumference was an independent predictor of the transition from a metabolically healthy status to an unhealthy status in all BMI categories (odds ratio: 1.059, 95% CI: 1.026‐1.032). Conclusions The MHO phenotype was associated with an increased incidence of diabetes in older adults. The presence of metabolic disorders in the group with MHO was associated with an increased diabetes risk and was predicted by the waist circumference at baseline.
    Type of Medium: Online Resource
    ISSN: 1930-7381 , 1930-739X
    URL: Article
    DOI: 10.1002/oby.22800
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2027211-X
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  • 6
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    Dynamic evolution of the anterior cingulate‐insula network during seizures
    Wiley ; 2023
    In:  CNS Neuroscience & Therapeutics Vol. 29, No. 12 ( 2023-12), p. 3901-3912
    Details
    In: CNS Neuroscience & Therapeutics, Wiley, Vol. 29, No. 12 ( 2023-12), p. 3901-3912
    Abstract: In physiological situations, the anterior cingulate cortex (ACC) and anterior insular cortex (AIC) are prone to coactivation. The functional connectivity and interaction between ACC and AIC in the context of epilepsy remain unclear. This study aimed to investigate the dynamic coupling between these two brain regions during seizures. Methods Patients who underwent stereoelectroencephalography (SEEG) recording were included in this study. The SEEG data were visually inspected and quantitatively analyzed. The narrowband oscillations and aperiodic components at seizure onset were parameterized. The frequency‐specific non‐linear correlation analysis was applied to the functional connectivity. The excitation/inhibition ratio (E:I ratio) reflected by the aperiodic slope was performed to evaluate the excitability. Results Twenty patients were included in the study, with 10 diagnosed with anterior cingulate epilepsy and 10 with anterior insular epilepsy. In both types of epilepsy, the correlation coefficient ( h 2 ) between the ACC and AIC at seizure onset exhibited a significantly higher value than that during interictal and preictal periods ( p 〈 0.05). The direction index (D) showed a significant increase at seizure onset, serving as an indicator for the direction of information flow between these two brain regions with up to 90% accuracy. The E:I ratio increased significantly at seizure onset, with the seizure‐onset zone (SOZ) demonstrating a more pronounced increase compared to non‐SOZ ( p 〈 0.05). For seizures originating from AIC, the E:I ratio was significantly higher in the AIC than in the ACC ( p = 0.0364). Conclusions In the context of epilepsy, the ACC and AIC are dynamically coupled during seizures. The functional connectivity and excitability exhibit a significant increase at seizure onset. By analyzing connectivity and excitability, the SOZ in ACC and AIC can be identified. The direction index (D) serves as an indicator for the direction of information flow from SOZ to non‐SOZ. Notably, the excitability of SOZ changes more significantly than that of non‐SOZ.
    Type of Medium: Online Resource
    ISSN: 1755-5930 , 1755-5949
    URL: Article
    DOI: 10.1111/cns.14310
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2423467-9
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  • 7
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    Online Resource
    High‐Efficiency E‐Beam Pumped Deep‐Ultraviolet Surface Emitter Based on AlGaN Ultra‐Thin Staggered Quantum Wells
    Wiley ; 2022
    In:  Advanced Optical Materials Vol. 10, No. 18 ( 2022-09)
    Details
    In: Advanced Optical Materials, Wiley, Vol. 10, No. 18 ( 2022-09)
    Abstract: A 2‐inch wafer‐scale electron‐beam (e‐beam) pumped deep‐ultraviolet surface emitter (DUVSE) with high efficiency and high output power at an emission wavelength of 248 nm is reported. This DUVSE benefits from ultra‐thin staggered AlN/AlGaN/GaN multiple quantum wells (MQWs), which compromise the electron–hole overlap and carrier confinement and thus significantly improve the emission efficiency. The wall‐plug‐efficiency (WPE) is increased by six times to 5.25% in comparison to that of conventional DUV light‐emitting devices (LEDs) based on AlGaN MQWs. This WPE is achieved under an anode voltage and current of 8 kV and 1 mA, where the output power is 420 mW. This output power can be further enhanced to 702 mW by increasing the anode current to 3 mA. The enhanced WPE and uniform electron beam distribution lighten the avenue to achieve a wafer‐scale high power dense DUV light source, which is a challenge for conventional DUV‐LEDs, in particular with an emission wavelength of less than 250 nm.
    Type of Medium: Online Resource
    ISSN: 2195-1071 , 2195-1071
    URL: Issue
    URL: Article
    DOI: 10.1002/adom.v10.18
    DOI: 10.1002/adom.202200011
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2708158-8
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  • 8
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    Online Resource
    Responses of Chemosensory Perception to Stimulation of the Human Brain
    Wiley ; 2023
    In:  Annals of Neurology Vol. 93, No. 1 ( 2023-01), p. 175-183
    Details
    In: Annals of Neurology, Wiley, Vol. 93, No. 1 ( 2023-01), p. 175-183
    Abstract: Significant advances have been made in our understanding of the neural substrates of human chemosensory processing, involving the piriform cortex, insula, and orbitofrontal cortex. However, the important and challenging issues are to localize the brain regions with high anatomic precision that can causally produce chemosensory perception and further delineate the topography of different classifications of chemosensory perception. Methods We quantitatively measured subjective responses of chemosensory perception to intracranial electrical stimulation over the brain in neurosurgical patients (n = 302) with medically refractory epilepsy. Results The chemosensory perceptions including olfaction, gustation, and chemesthesis were elicited in 21 of 302 patients (7%). Chemosensory responses were evoked in 53 (0.2%) of 21,661 stimulated sites. The highest response rate (1.8%) was in the insula (37/2,051 stimulated sites from 15/163 patients). The chemosensory perception emerged predominantly during stimulation of the insula along the central sulcus axis. Notably, there existed a distinct pattern that the anteroventral insula predominately represented orthonasal olfaction, whereas different chemosensory modalities converged in the mid‐dorsal insula. Interpretation This study provided a detailed characterization of chemosensory perception across the brain, especially in the insula. These results suggest that the cortex along the banks of the central sulcus of the insula may play a role in producing the supramodal sensation of flavor. It also indicates that dysfunction of the central insula should be considered during the evaluation of chemosensory‐related epileptic seizures. ANN NEUROL 2023;93:175–183
    Type of Medium: Online Resource
    ISSN: 0364-5134 , 1531-8249
    URL: Issue
    URL: Article
    DOI: 10.1002/ana.v93.1
    DOI: 10.1002/ana.26532
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2037912-2
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  • 9
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    Online Resource
    Interface Dipole Management of D–A‐Type Molecules for Efficient Perovskite Solar Cells
    Wiley ; 2024
    In:  Angewandte Chemie Vol. 136, No. 30 ( 2024-07-22)
    Details
    In: Angewandte Chemie, Wiley, Vol. 136, No. 30 ( 2024-07-22)
    Abstract: Interfacial engineering of perovskite films has been the main strategies in improving the efficiency and stability of perovskite solar cells (PSCs). In this study, three new donor‐acceptor (D–A)‐type interfacial dipole (DAID) molecules with hole‐transporting and different anchoring units are designed and employed in PSCs. The formation of interface dipoles by the DAID molecules on the perovskite film can efficiently modulate the energy level alignment, improve charge extraction, and reduce non‐radiative recombination. Among the three DAID molecules, TPA‐BAM with amide group exhibits the best chemical and optoelectrical properties, achieving a champion PCE of 25.29 % with the enhanced open‐circuit voltage of 1.174 V and fill factor of 84.34 %, due to the reduced defect density and improved interfacial hole extraction. Meanwhile, the operational stability of the unencapsulated device has been significantly improved. Our study provides a prospect for rationalized screening of interfacial dipole materials for efficient and stable PSCs.
    Type of Medium: Online Resource
    ISSN: 0044-8249 , 1521-3757
    URL: Issue
    URL: Article
    DOI: 10.1002/ange.v136.30
    DOI: 10.1002/ange.202404289
    RVK:
    VA 2100
    RVK:
    VN 5020
    Language: English
    Publisher: Wiley
    Publication Date: 2024
    detail.hit.zdb_id: 505868-5
    detail.hit.zdb_id: 506609-8
    detail.hit.zdb_id: 514305-6
    detail.hit.zdb_id: 505872-7
    detail.hit.zdb_id: 1479266-7
    detail.hit.zdb_id: 505867-3
    detail.hit.zdb_id: 506259-7
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  • 10
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    Interface Dipole Management of D–A‐Type Molecules for Efficient Perovskite Solar Cells
    Wiley ; 2024
    In:  Angewandte Chemie International Edition Vol. 63, No. 30 ( 2024-07-22)
    Details
    In: Angewandte Chemie International Edition, Wiley, Vol. 63, No. 30 ( 2024-07-22)
    Abstract: Interfacial engineering of perovskite films has been the main strategies in improving the efficiency and stability of perovskite solar cells (PSCs). In this study, three new donor‐acceptor (D–A)‐type interfacial dipole (DAID) molecules with hole‐transporting and different anchoring units are designed and employed in PSCs. The formation of interface dipoles by the DAID molecules on the perovskite film can efficiently modulate the energy level alignment, improve charge extraction, and reduce non‐radiative recombination. Among the three DAID molecules, TPA‐BAM with amide group exhibits the best chemical and optoelectrical properties, achieving a champion PCE of 25.29 % with the enhanced open‐circuit voltage of 1.174 V and fill factor of 84.34 %, due to the reduced defect density and improved interfacial hole extraction. Meanwhile, the operational stability of the unencapsulated device has been significantly improved. Our study provides a prospect for rationalized screening of interfacial dipole materials for efficient and stable PSCs.
    Type of Medium: Online Resource
    ISSN: 1433-7851 , 1521-3773
    URL: Issue
    URL: Article
    DOI: 10.1002/anie.v63.30
    DOI: 10.1002/anie.202404289
    RVK:
    VA 2100
    Language: English
    Publisher: Wiley
    Publication Date: 2024
    detail.hit.zdb_id: 2011836-3
    detail.hit.zdb_id: 123227-7
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