In:
Journal of Diabetes Investigation, Wiley, Vol. 9, No. 3 ( 2018-05), p. 512-521
Abstract:
Impaired glucose tolerance ( IGT ) is a subtype of prediabetes, a condition having high risk for development to diabetes mellitus, but its pathophysiology is not fully understood. In the present study, we examined metabolic changes in IGT by using two types ( D‐ glucose [Glc] and partial hydrolysate of starch [ PHS ]) of oral glucose tolerance tests ( OGTT s), with emphasis on serum incretins and metabolites. Materials and Methods We carried out the two types of OGTT (Glc/ OGTT and PHS / OGTT ) in 99 young Japanese individuals who had tested either positive ( GU + ; n = 48) or negative ( GU − ; n = 51) for glycosuria. After OGTT , they were sub‐grouped into five categories: normal glucose tolerance ( NGT ) in the GU − group ( GU − / NGT ; n = 49), NGT in the GU + group ( GU + / NGT ; n = 28), IGT ( n = 12), diabetes mellitus ( n = 1) and renal glycosuria ( n = 9). Serum incretin and metabolites of GU − / NGT and IGT were then measured. Results When the serum insulin level at each time‐point during PHS / OGTT was expressed as its ratio relative to Glc/ OGTT , it was increased time‐dependently in GU − / NGT , but not in IGT . Such an increase in the ratio was also detected of serum incretin levels in GU − / NGT , but not in IGT , suggesting a lack of deceleration of oligosaccharide absorption in IGT . Metabolome analysis showed a difference in the serum levels of two metabolites of unknown function in mammals, methylcysteine and sedoheptulose 1,7‐bisphosphate, between GU − / NGT and IGT . Conclusions Comparison of PHS / OGTT and Glc/ OGTT showed that oligosaccharide absorption was accelerated in IGT . Methylcysteine and sedoheptulose 1,7‐bisphosphate could be novel markers for dysregulated glucose metabolism.
Type of Medium:
Online Resource
ISSN:
2040-1116
,
2040-1124
DOI:
10.1111/jdi.2018.9.issue-3
Language:
English
Publisher:
Wiley
Publication Date:
2018
detail.hit.zdb_id:
2542077-X
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