Format:
Online-Ressource (XI, 290 p. 70 illus. in color, online resource)
ISBN:
9789401786133
Series Statement:
SpringerLink
Content:
The "bioelectronic nose, the device which has a similar function to the human smell sensing system, can be realized by combining the olfactory cells or receptors with nanotechnology. In the last two decades, much has been learned about the smell sensing mechanism in biological systems. With knowledge about the biological olfactory system and the techniques for the expression of biological receptor proteins, we are able to utilize biological materials and systems to mimic the biological olfactory system. In addition to the advances in biological and biotechnological area, nanotechnology has progressed to a great degree. The bioelectronic nose is a good example of the integration of biotechnology and nanotechnology. This book describes basic biological sciences of the olfactory system, biotechnology for the production of olfactory biological elements, and nanotechnology for the development of various sensing devices. The purpose of this book is to provide the reader with a concept, basic sciences, fundamental technologies, applications, and perspectives of the bioelectronic nose.
Note:
Literaturangaben
,
Preface ; Contents; Contributors; Chapter 1; Concept of Bioelectronic Nose; 1.1 History of Artificial Smelling Methods; 1.1.1 Trained Animal; 1.1.2 Electronic Nose; 1.1.2.1 Principle of Electronic Nose; 1.1.2.2 Characteristics of Electronic Nose; 1.1.3 Bioelectronic Nose; 1.2 Concept of Bioelectronic Nose; 1.2.1 Biological Recognition Element; 1.2.1.1 Receptor-Based Bioelectronic Nose; 1.2.1.2 Cell-Based Bioelectronic Nose; 1.2.1.3 Nanovesicle-Based Bioelectronic Nose; 1.2.2 Signal Transducer; 1.2.2.1 Quartz Crystal Microbalance; 1.2.2.2 Surface Plasmon Resonance
,
1.2.2.3 Electrochemical Impedance Spectroscopy1.2.2.4 Planar Microelectrode; 1.2.2.5 Field-Effect Transistor; 1.3 Characteristics of Bioelectronic Nose; 1.3.1 Sensitivity; 1.3.2 Selectivity; 1.3.3 Human-like Behavior; 1.3.4 Stability; 1.4 Current Trends in Bioelectronic Noses; References; Chapter 2; Mechanisms of Olfaction; 2.1 Importance of Olfaction; 2.2 The Vertebrate Olfactory System; 2.3 Main Olfactory Epithelium; 2.3.1 Anatomy; 2.4 Odorant Receptors; 2.4.1 Receptor Signaling and Termination; 2.4.2 Desensitization and Adaptation; 2.4.3 Receptor Surface Expression
,
2.4.4 Receptor Gene Regulation2.4.5 Receptor Expression Zones and Projection of OSN Axons; 2.5 Odor Coding; 2.6 Minority Receptors; 2.7 Odorant Binding Proteins (OBPs); 2.8 Vomeronasal Organ (VNO); 2.9 Olfactory System in Aquatic Vertebrates; 2.10 The Insect Olfactory System; 2.11 Nematode Olfactory System; 2.12 Future Directions in the Field; References; Chapter 3; Olfactory Receptor Proteins; 3.1 Olfactory Receptors: Genes and Protein Expression; 3.2 G-protein Coupled and Olfactory Receptors Sequences and Three-Dimensional Structures; 3.3 Signal Transduction Mechanisms
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3.4 Olfactory Receptors Molecular Modeling and Virtual Screening3.5 Olfactory Receptor Activity Regulation: Homodimerization, Binding Cooperativity and Allostery; 3.6 Use of Olfactory Receptor Protein in Bioelectronic Noses; References; Chapter 4; Odorant-Receptor Interaction; 4.1 Introduction; 4.2 Combinatorial Coding of Olfaction; 4.3 Odorant Receptor Tuning; 4.4 Role of Mucus in Odorant Recognition; 4.5 Predicting Odorant-Receptor Interactions; 4.6 Conclusion; References; Chapter 5; Cell-Based System for Identification of Olfactory Receptors; 5.1 Introduction
,
5.2 OSN-Based Methods for Identifying Odorant Receptor Function5.3 Functional Expression of Odorant Receptors in Heterologous Cells; 5.4 Heterologous Cell Types; 5.5 Do in Vitro Systems Replicate in Vivo OR Responses?; 5.6 Concluding Remarks; References; Chapter 6; Neurobiology and Cultivation of Olfactory Receptor Neurons on a Chip; 6.1 Introduction; 6.2 Cellular Structures of Olfactory Cells; 6.2.1 ORNs; 6.2.2 Olfactory Precursor Cells; 6.2.3 SCs; 6.2.4 Olfactory Signal Transduction in the Olfactory Cilia; 6.2.5 Neuronal Differentiation of Olfactory Precursor Cells
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6.2.6 Olfactory Cells as Biosensors
Additional Edition:
ISBN 9789401786126
Additional Edition:
Druckausg. ISBN 978-940-178-612-6
Additional Edition:
Druckausg. Bioelectronic nose Dordrecht [u.a.] : Springer, 2014 ISBN 9401786127
Additional Edition:
ISBN 9789401786126
Language:
English
Keywords:
Olfaktometrie
;
Biomedizinische Technik
;
Nanotechnologie
;
Biotechnologie
;
Chemischer Sensor
DOI:
10.1007/978-94-017-8613-3
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