Format:
Online-Ressource (digital)
ISBN:
9783642043024
,
1282828789
,
9781282828780
Series Statement:
Research and Perspectives in Endocrine Interactions
Content:
Insulin-like growth factors (IGFs), their binding proteins and their receptors play important roles in regulating growth, metabolism, proliferation and survival for many cells and tissues throughout lifespan in humans and other species. Circulating IGF1 is known to be an endocrine regulator, with metabolic effects related to, and partly convergent with, insulin signalling. IGF1 also mediates many of the growth promoting effects of GH, and there is an ongoing debate as to the relative contributions of endocrine-, vs locally-derived IGF1 for systemic growth. More recently however, it has become clear that IGFs may be key local growth and cellular survival factors for many different tissues, active from early in embryonic development, essential for normal maturation and growth during foetal life. IGFs continue to play important roles throughout adult life in many diverse processes such as tissue repair, cellular proliferation, tissue remodelling and metabolic regulation. IGF systems are tightly regulated, orderly control of cellular repair and metabolism is central to healthy ageing, whilst uncontrolled proliferation can lead to cancer.
Note:
Includes bibliographical references and index
,
FM; 1; 2; 3; 4; 5; 6; 7; 8; 9; 10; 11; BM
Additional Edition:
ISBN 9783642043017
Additional Edition:
Buchausg. u.d.T. IGFs: local repair and survival factors throughout life span Berlin : Springer, 2010 ISBN 9783642043017
Language:
English
Subjects:
Biology
Keywords:
Insulin-like Growth Factor
;
Insulin-like Growth Factor
;
Aufsatzsammlung
;
Konferenzschrift
DOI:
10.1007/978-3-642-04302-4
URL:
Volltext
(lizenzpflichtig)
Author information:
Clemmons, David
Author information:
Christen, Yves 1948-
Bookmarklink
