Format:
Online-Ressource (VIII, 313 p. 46 illus., 40 illus. in color, digital)
ISBN:
9789400760288
Series Statement:
Cancer Metastasis - Biology and Treatment 19
Content:
There has been a dramatic increase in knowledge of tight junctions in the past decade. The molecular structure of tight junctions, cellular functions and the pathophysiological roles of tight junctions are becoming clear. Of the most important functions, the role of the cellular structure in cancer spread and drug delivery are increasingly realised. It is now clear that there are fundamental changes to tight junctions during the process of cancer development. Tight junctions are also critical to the metastatic process of cancer cells. The cellular structure is also crucial in drug therapies, namely, the permeability and bioavailability of the drugs, penetration of barriers such as the blood brain barrier. This current volume aims to summarise the current knowledge of tight junctions, their role in cancer and cancer metastasis and is of interest to scientists and clinicians
Note:
Includes bibliographical references and index
,
Tight Junctions in Cancer Metastasis; Preface; Contents; Chapter 1: The Molecular Aspects of Tight Junctions; 1.1 Introduction; 1.2 Physiological Processes Which Involve Tight Junction Proteins; 1.2.1 Establishment of Cell Adhesion and Polarity; 1.2.2 Cell-Matrix Signaling; 1.2.3 Alterations in Ion Transport; 1.2.4 Hormone Effects; 1.2.5 Pro-inflammatory Cytokines; 1.2.6 Hypoxia; 1.3 Pathophysiological Processes in Cancer Influenced by Tight Junctions; 1.3.1 Regulation of Cell Proliferation and Apoptosis; 1.3.2 Migration and Invasion; 1.3.3 Cell Fate and Differentiation
,
1.3.4 Metastasis and the Blood-Brain Barrier1.3.5 Angiogenesis; 1.4 Conclusion; References; Chapter 2: The Distribution of Tight Junctions and Junctional Proteins in the Human Body; 2.1 Introduction; 2.1.1 Classical Functions of Junctional Proteins: Formation and Regulation of Tissue Barriers; 2.1.2 Non-classical Functions of Junctional Proteins; 2.1.2.1 The Regulation of Gene Expression; 2.1.2.2 Role of Tight Junction Proteins in Epithelial Cell Migration; 2.2 Tight Junctions in Tissues of Ectodermal Origin; 2.2.1 Tight Junctions in the Epidermis; 2.2.2 Tight Junctions in the Mammary Glands
,
2.2.3 Tight Junctions in the Sensory Epithelium of Ears, Nose and Eyes2.2.3.1 Tight Junctions in the Acoustic Organs; 2.2.3.2 Tight Junctions in the Corneal Epithelial Cells; 2.2.3.3 Tight Junctions in the Nasal Olfactory Mucosa; 2.3 Tight Junctions in Tissues of Endodermal Origin; 2.3.1 Tight Junctions in the Respiratory Tract; 2.3.2 Tight Junctions in the Esophagus; 2.3.3 Tight Junction Expression in Epithelial Lining of the Guts; 2.3.4 Tight Junctions in the Parenchyma of Liver; 2.3.5 Tight Junctions in the Biliary Tract; 2.3.6 Tight Junctions in the Parenchyma of Pancreas
,
2.3.7 Tight Junctions in the Epithelial Lining of Urinary Bladder and Urethra2.3.8 Tight Junctions in the Parenchyma of Thyroid Glands; 2.4 Tight Junctions in Tissues of Mesodermal Origin; 2.4.1 Tight Junctions in the Kidney; 2.4.2 Tight Junctions in the Uterine Cervix; 2.4.3 Tight Junctions in the Endometrium; 2.4.4 Tight Junction Expression in Ovarian Cell Surface and Ovarian Cancer; 2.4.5 Tight Junctions in the Prostate; 2.4.6 Tight Junctions in the Testis; References; Chapter 3: Methods to Study Tight Junctions; 3.1 Introduction; 3.2 The Tight Junction (TJ) in Retrospect
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3.3 The Ability of the TJ to Adjust Its Hermeticity to Physiological Needs3.3.1 Specific Techniques an Approaches to Study TJs; 3.3.1.1 Transmission Electron Microscopy (TEM); 3.3.1.2 Freeze-Fracture Electron Microscopy (FF); 3.3.1.3 Flux of Dextran; 3.3.1.4 Transepithelial Electrical Resistance (TER); 3.3.1.5 Electric Current Paths Through an Epithelium; 3.3.1.6 "Discrepancies" Between Permeability and TER; 3.3.1.7 Monolayers of Epithelial Cell Lines Cultured on a Permeable Support; 3.3.1.8 The Calcium Switch; References
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Chapter 4: Enhanced Vascular Permeability in Solid Tumors: A Promise for Anticancer Nanomedicine
,
Preface -- The molecular aspects of Tight junctions -- The distribution of tight junctions and junctional proteins in the body -- Methodologies in investigation tight junctions -- Vascular permeability and drug delivery -- Tight junctions, BBB and brain metastasis -- Tight junctions and bladder cancer metastasis -- Tight Junctions and colorectal cancer therapies -- Tight junctions in breast cancer -- Regulation of tight junctions for therapeutic advantages -- Overcoming tight junctional permeability in cerebral metastasis -- CL-5 and cancer metastasis -- Intracellular signalling in TJ and AJ -- ROCK and TJ -- Index.
Additional Edition:
ISBN 9789400760271
Additional Edition:
Buchausg. u.d.T. Tight junctions in cancer metastasis Heidelberg [u.a.] : Springer, 2013 ISBN 9789400760271
Language:
English
Subjects:
Biology
Keywords:
Tight junction
;
Metastase
;
Aufsatzsammlung
DOI:
10.1007/978-94-007-6028-8
URL:
Volltext
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