In:
Chemistry – A European Journal, Wiley, Vol. 28, No. 11 ( 2022-02-21)
Abstract:
Minimalist photo‐reactive probes, which consist of a photo‐reactive group and a tag for detection of target proteins, are useful tools in chemical biology. Although several diazirine‐based and aryl azide‐based minimalist probes are available, no keto‐based minimalist probe has yet been reported. Here we describe minimalist probes based on a 2‐thienyl‐substituted α‐ketoamide bearing an alkyne group on the thiophene ring. The 3‐alkyne probe showed the highest photo‐affinity labeling efficiency.
Type of Medium:
Online Resource
ISSN:
0947-6539
,
1521-3765
DOI:
10.1002/chem.202103925
Language:
English
Publisher:
Wiley
Publication Date:
2022
detail.hit.zdb_id:
1478547-X
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