UID:
almahu_9947366534502882
Format:
1 online resource (426 p.)
Edition:
1st ed.
ISBN:
1-282-55250-3
,
9786612552502
,
0-08-092041-1
Content:
Animal and Translational Models for CNS Drug Discovery combines the experience of academic, clinical and pharmaceutical neuroscientists in a unique collaborative approach to provide a greater understanding of the relevance of animal models of neuropsychiatric disorders and their role as translational tools for the discovery of CNS drugs being developed for the treatment of these disorders. The focus of this three-volume series of essays is to present a consensual picture of the translational value of animal models from leading experts actively involved in the use of animal models for
Note:
Description based upon print version of record.
,
Front Cover; Animal and Translational Models for CNS Drug Discovery; Copyright Page; Contents; Preface; Acknowledgements; List of Contributors; CHAPTER 1 Impulse and Reward Deficit Disorders: Drug Discovery and Development; Introduction; The Key Messages of Epidemiology: What should be Modeled?; Drug Addiction; Behavioral Addictions; Comorbid Associations; From Epidemiology to Unmet Medical Needs to Drug Discovery and Development; Challenges Facing Drug Discovery and Development in Impulse and Reward Deficit Disorders
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Toward Translational Value of Animal Models in Impulse and Reward Deficit DisordersKey Neurosystems Relevant to Drug Discovery and Development; Key Experimental Paradigms with Translational Potential for Drug Discovery and Development; Compulsive/Impulsive Behaviors; Target Validation and Throughput Limitations; Target Validation, Validity, Reliability, and Automation; Conclusions; References; CHAPTER 2 Drug Discovery and Development for Reward Disorders: Views from Government; Introduction and Contextual Issues; Division of Pharmacotherapies and Medical Consequences of Drug Abuse
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Drug Discovery Program - Initial OperationsDrug Discovery Program - Current Status; Development of Medications for Opiate and Cocaine Addiction; Animal Models in the Discovery of Drug Addiction Treatments; The Validity of Animal Models in the Field of Drug Addiction; Use of Data from Animal Models for ""Go/No Go"" Decisions; Avoiding False Positives in Drug Self-administration and Relapse Model Testing; Translational Research, Human Laboratory Models, and the Bridge between Animal Models and Clinical Efficacy Trials; References
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CHAPTER 3 Issues in Designing and Conducting Clinical Trials for Reward Disorders: A Clinical ViewIntroduction; Utility of Research using Animal Models; Advantages of Animal Research; Drug Exposure; Behavioral Techniques in Animal Research; Drug Self-administration; Human Testing Paradigms for New Medications; Human Laboratory; Self-administration; Neuroimaging; Methodological Issues in Clinical Trials; Target Population and Subject Selection; General Design Issues; Statistical Issues; Conclusions; Acknowledgments; References
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CHAPTER 4 The Role of Animal Models in Reward Deficit Disorders: Views from AcademiaIntroduction and Definitions; Face and Construct Validity of Animal Models of Reward Deficits in Psychiatric Illness; Face Validity and Construct Validity of Animal Models of Reward Deficits in Psychiatric Disorders; Brain Stimulation Reward; Sucrose Consumption/Sucrose Preference; Progressive-Ratio Responding; Drug Withdrawal Model of Dependence; Brain Stimulation Reward As a Measure of the Reward Deficits Associated with Drug Dependence
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Sucrose Intake/Preference As a Measure of the Reward Deficits Associated with Drug Dependence
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English
Additional Edition:
ISBN 0-12-373861-X
Language:
English
Subjects:
Chemistry/Pharmacy
,
Medicine
URL:
Volltext
(URL des Erstveröffentlichers)
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