In:
The Journal of the Acoustical Society of America, Acoustical Society of America (ASA), Vol. 131, No. 4_Supplement ( 2012-04-01), p. 3323-3323
Abstract:
In this paper, a new composite nano-particle for both contrast-enhanced ultrasound imaging and cell therapy is introduced. The carbon nanotubes are used for carriers due to their unique hollow structure, nano-diameter and good biocompatibility. The targeted protein, the hematoporphyrin and the gold nanoparticles are assembled on the surface of the carbon nanotubes. The targeted protein is used as tumor localization. As a kind of sonosensitizer, the hematoporphyrin can produce the singlet oxygen while being activated by ultrasound and are studied for its effects of antitumor and apoptosis induction recently. It is worthwhile to note that the singlet oxygen has a very short lifetime and will transfer to triplet oxygen with light emission band at 1268 nm, or 634 nm and 703 nm. Triplet oxygen is the ground state of the oxygen molecule and much of them will form nano oxygen bubbles under body temperature which can be used as contrast-enhanced ultrasound imaging agent. At the same time, the gold nanoparticles which have good biocompatibility can absorb the light emission and produce the acoustic signals of some bandwidth. This work is supported by the National Natural Science Foundation of China (No. 10804085, 11174223 and 50603019), and the Shanghai Nano Special Foundation(No. 1052nm05400)
Type of Medium:
Online Resource
ISSN:
0001-4966
,
1520-8524
Language:
English
Publisher:
Acoustical Society of America (ASA)
Publication Date:
2012
detail.hit.zdb_id:
1461063-2
Bookmarklink
