Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • Medicine  (2)
Type of Medium
Publisher
Language
Years
Subjects(RVK)
  • Medicine  (2)
RVK
  • 1
    In: Clinical Endocrinology, Wiley
    Abstract: Primary polydipsia is characterized by excessive fluid intake which may suppress vasopressin levels. It is speculated that suppressed vasopressin levels lead to a dysregulated hypothalamic–pituitary–adrenal (HPA) axis as vasopressin co‐modulates the HPA axis. However, data are contradictory. The aim of this study was to investigate markers of the HPA axis in patients with primary polydipsia compared to healthy controls. Design Exploratory analysis combining data from two different prospective observational studies. Patients We included 34 patients with primary polydipsia (68% females, median aged 29.5 years (interquartile range, IQR: 26.0, 38.8) and 20 healthy controls (55% females, median age 24.0 years [IQR: 22.0, 27.2]). Measurements The main outcome was difference in HPA axis activity assessed using circadian serum and salivary cortisol, 24‐h urinary free cortisol and cortisol levels before and after adrenocorticotropic hormone (ACTH) stimulation; vasopressin suppression was assessed measuring fasting copeptin levels between patients with primary polydipsia and healthy controls using Wilcoxon rank‐sum test. Results No difference was seen in circadian serum cortisol levels ( p  = .9), urinary free cortisol levels ( p  = .17) and serum cortisol in response to ACTH stimulation ( p  = .77) between groups. Circadian salivary cortisol levels were significantly lower in patients with primary polydipsia compared to healthy controls with an estimated difference of −3.7 nmol/L (95% CI: −5.5, −1.8 nmol/L, p   〈  .001). Fasting copeptin levels were significantly lower in patients with primary polydipsia compared to healthy volunteers ( p   〈  0.01). Conclusion Our results suggest no difference in HPA axis activity between patients with primary polydipsia and healthy controls. The observed difference in salivary cortisol levels may be linked to a dilution effect in saliva rather than an altered stress axis considering the other findings.
    Type of Medium: Online Resource
    ISSN: 0300-0664 , 1365-2265
    RVK:
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2004597-9
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 2
    Online Resource
    Online Resource
    Georg Thieme Verlag KG ; 2019
    In:  Klinische Monatsblätter für Augenheilkunde Vol. 236, No. 04 ( 2019-04), p. 442-445
    In: Klinische Monatsblätter für Augenheilkunde, Georg Thieme Verlag KG, Vol. 236, No. 04 ( 2019-04), p. 442-445
    Abstract: Background To compare two commonly used strengthening procedures in strabismus surgery: plication and resection of the extraocular muscle (EOM). Patients and Methods From an anonymous databank of strabismus surgeries, performed at the University Eye Hospital Basel, patients with a horizontal strabismus surgery, consisting of a recession combined with either plication or resection of the antagonist and a follow-up of at least 3 months, were included. Exclusion criteria were previous eye surgeries, binocular surgeries, and simultaneous surgery of oblique or vertical EOM. Pre- and postoperative angles were measured using the alternating prism cover test during fixation at distance. Results Fifty-nine patients met the criteria and were matched according to the angle at baseline in the recession/plication group, resulting in 12 resection/recession and 12 plication/recession patients. There was no significant difference in the number of eso- and exodeviations, age at surgery, or gender between the groups. Mean difference between plication and resection was 1.2 PD at 1 week (p = 0.72) and 1.7 PD at 3 months (p = 0.61). A separate analysis for eso- and exodeviations showed no significant difference between recession/plication and recession/resection at 1 week or 3 months (p value side effect = 0.59; resection vs. plication at 1 week p = 0.68; resection vs. plication at 3 months: p = 0.57). The overall dose effect (SD) was 2.13 PD (0.88)/mm in the recession/plication group and 2.51 PD (0.81)/mm in the recession/resection group after 1 week (p = 0.331). After 3 months, the mean dose effect was 1.85 PD (1.06)/mm in the recession/plication group and 2.09 PD (1.12)/mm in the recession/resection group (p = 0.611). Discussion Our findings show that recession/plication is a valid alternative to recession/resection in horizontal strabismus without the need to cut the muscle, as we saw no difference in surgical effectiveness in either eso- or exodeviations at 1 week or at 3 months.
    Type of Medium: Online Resource
    ISSN: 0023-2165 , 1439-3999
    RVK:
    Language: English
    Publisher: Georg Thieme Verlag KG
    Publication Date: 2019
    detail.hit.zdb_id: 2039754-9
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. Further information can be found on the KOBV privacy pages