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  • 1
    Book
    Book
    Details
    UID:
    (DE-605)(DE-238)0434772
    Format: 216 Seiten , Illustrationen, farbig
    Language: German
    Library Location Call Number Volume/Issue/Year Availability
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    Book
    HBZ
  • 2
    Online Resource
    Online Resource
    Design, Syntheses and Bioactivities of Androgen Receptor Targeted Taxane Analogs, Simplified Fluorescently Labeled Discodermolide Analogs, and Conformationally Constrained Discodermolide Analogs (2010)
    [Erscheinungsort nicht ermittelbar] : Virginia Tech
    Details
    UID:
    (DE-627)1803575581
    Content: Prostate cancer is the most common non-skin cancer for men in America. The androgen receptor exerts transcriptional activity and plays an important role for the proliferation of prostate cancer cells. Androgen receptor ligands bind the androgen receptor and inhibit its transcriptional activity effectively. However, prostate cancer can progress to hormone refractory prostate cancer (HRPC) to avoid this effect. Chemotherapies are currently the primary treatments for HRPC. Unfortunately, none of the available chemotherapies are curative. Among them, paclitaxel and docetaxel are two of the most effective drugs for HRPC. More importantly, docetaxel is the only form of chemotherapy known to prolong survival in the HRPC patients. We hypothesized that the conjugation of paclitaxel or docetaxel with an androgen receptor ligand will overcome the resistance mechanism of HRPC. Eleven conjugates were designed, synthesized and biologically evaluated. Some of them were active against androgen-independent prostate cancer, but they were all less active than paclitaxel and docetaxel. Discodermolide is a microtubule interactive agent, and has a similar mechanism of action to paclitaxel. Interestingly, discodermolide is active against paclitaxel-resistant cancer cells and can synergize with paclitaxel, which make it an attractive anticancer drug candidate. Understanding the bioactive conformation of discodermolide is important for drug development, but this task is difficult due to the linear and flexible structure of discodermolide. Indirect evidence for the orientation of discodermolide in the tubulin binding pocket can be obtained from fluorescence spectroscopy of the discodermolide tubulin complex. For this purpose, we designed and synthesized a simplified fluorescently labeled discodermolide analog, and it was active in the tubulin assembly bioassay. In addition, a conformationally constrained discodermolide was designed to mimic the bioactive conformation according to computational modeling. The synthetic effort was made, but failed during one of the final steps. ; Ph. D.
    Note: Dissertation Virginia Tech 2010
    Language: Undetermined
    URL: kostenfrei
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    Online Resource
    BSZ
    GBV
  • 3
    Book
    Book
    Qinxin : Qi Jun diyi ben shu (1988)
    Taipei : Erya chubanshe
    Details
    UID:
    (DE-605)TT003286980
    Format: 8, 211 S.
    Edition: 19. Aufl.
    Original writing title: 琴心
    Original writing title: 琦君 的 第一 本 書
    Original writing person/organisation: 琦君
    Series Statement: Erya congshu 82
    Note: In chines. Schr
    Language: Chinese
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    Book
    HBZ
  • 4
    Book
    Book
    Cichu you xiantao (1988)
    Taipei : Jiuge chubanshe
    Details
    UID:
    (DE-605)TT003286984
    Format: 255 S.
    Edition: 10. Aufl.
    Original writing title: 此處 有 仙 桃
    Original writing person/organisation: 琦君
    Series Statement: Jiuge wenku 168
    Note: In chines. Schr
    Language: Chinese
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    Book
    HBZ
  • 5
    Book
    Book
    Mu xin si tiankong (1981)
    Taipei : Erya chubanshe
    Details
    UID:
    (DE-605)TT003286982
    Format: 3, 222 S.
    Edition: 1. Aufl.
    Original writing title: 母 心 似 天空
    Original writing person/organisation: 琦君
    Series Statement: Erya congshu 101
    Note: In chines. Schr
    Language: Chinese
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  • 6
    Book
    Book
    〈〈The〉〉 development of beef cattle production in Korea (1994)
    Taipei : FFTC
    Details
    UID:
    (DE-605)HT014651637
    Format: 11 S.
    Series Statement: Extension bulletin / Food & Fertilizer Technology Center 386
    Note: Literaturangaben , Zsfassung in chines., japan. und korean. Sprache
    Language: English
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    HBZ
  • 7
    Book
    Book
    wan shui qian shan shi you qing (2006)
    tai bei
    Details
    UID:
    (DE-602)gbv_1039664261
    Format: 222 S.
    Edition: 第 2 版, 增订版
    Original writing title: 万水千山师友情
    Original writing person/organisation: 琦君
    Original writing publisher: 台北 : 九歌出版社
    ISBN: 9574443272
    Series Statement: qi jun zuo pin ji 7
    Note: 有附录 , SBB-PK Berlin
    Language: Chinese
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  • 8
    Book
    Book
    qin xin (1987)
    tai bei
    Details
    UID:
    (DE-602)gbv_1037331257
    Format: 8, 211 S.
    Original writing title: 琴心
    Original writing person/organisation: 琦君
    Original writing publisher: 台北 : 尔雅出版社
    Series Statement: er ya cong shu 82
    Note: SBB-PK Berlin
    Language: Chinese
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  • 9
    Book
    Book
    mu xin shi tian kong (1987)
    tai bei
    Details
    UID:
    (DE-602)gbv_103808959X
    Format: 3, 222 S.
    Original writing title: 母心似天空
    Original writing person/organisation: 琦君
    Original writing publisher: 台北 : 尔雅出版社
    Series Statement: er ya cong shu 101
    Note: SBB-PK Berlin
    Language: Chinese
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  • 10
    Book
    Book
    qi jun san wen xuan zhong ying dui zhao (2007)
    tai bei
    Details
    UID:
    (DE-602)gbv_1033072427
    Format: 19,330 S.
    Original writing title: 琦君散文选中英对照
    Original writing person/organisation: 琦君
    Original writing publisher: 台北 : 九歌出版社
    ISBN: 9789574444120
    Series Statement: qi jun zuo pin ji 12
    Note: Text in chin. u. engl. Spr , SBB-PK Berlin
    Language: Chinese
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