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  • 1
    In: Revista do Instituto de Medicina Tropical de São Paulo, FapUNIFESP (SciELO), Vol. 60, No. 0 ( 2018-04-23)
    Type of Medium: Online Resource
    ISSN: 1678-9946
    Language: Unknown
    Publisher: FapUNIFESP (SciELO)
    Publication Date: 2018
    detail.hit.zdb_id: 2017173-0
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  • 2
    In: Blood, American Society of Hematology, Vol. 114, No. 22 ( 2009-11-20), p. 1413-1413
    Abstract: Abstract 1413 Poster Board I-436 Objectives: There are relatively few centers across the United States that either specialize in SCD care or have day hospitals where patients can be evaluated and urgently treated for acute pain crises. While most patients come to the ED for management of an acute pain crisis, SCD patients are at risk for many life-threatening complications. Most patients with SCD require an ED visit at some point. The complexity of SCD warrants a comprehensive assessment in the emergency department. While it may be challenging to conduct such an assessment in the ED, a succinct decision support tool may help guide clinicians in the performance of such an assessment. The benefits of such an assessment would identify unmet patient needs and help guide ED management and referrals. The goal of this project was to develop a brief, easy to use tool that guides the emergency clinicians in the identification of such needs and aid in accomplishing the following goals: 1) rapidly and aggressively manage ED pain, 2) identify other life-threatening conditions, 3) decrease hospital admission rates, 4) decrease return visits to the ED, 5) identify and increase the number of referrals made from the ED setting, and 6) increase both patient and clinician satisfaction with the ED experience. Methods: A series of seven clinician and patient focus groups were conducted in four cities across the United States (Chicago, Denver, Durham, and New York) to obtain key stakeholder input. Visits at three SCD centers of excellence (University of Colorado Denver, Duke University, Virginia Commonwealth University) were conducted, a literature search was conducted, and the PI attended SCD clinics to observe practice patterns with sickle cell experts at the University of Illinois and University of Chicago sickle cell clinics. Focus group data was analyzed using qualitative methods and is reported elsewhere. All data was synthesized and a draft tool was created and reviewed by outside experts. Revisions were made. Results: The following six key decisions were identified as being critical in achieving the tools aims: (1) what is the correct triage level, (2) how should pain be treated, (3) does the patient require a diagnostic work-up, (4) should the patient be admitted to the hospital, (5) if discharged home, is there a need for analgesic prescriptions, and (6) does the patient need a referral to a sickle cell expert or mental health or social services? Supporting data elements for each decision were also identified and included as part of the tool which will be formulated into an easy to use algorithm. Data elements include key history and physical indicators of a potential high risk situation necessitating further evaluation, pain assessment and history of analgesic use, relationship with a sickle cell expert, ED and hospital utilization history, and evaluation of psychosocial needs (self-report of anxiety or depression, work/employment status, home situation). Conclusions: Critical decisions and associated supporting elements to facilitate ED management were identified. Future work will involve finalizing and testing this communimetric tool, which will guide emergency department evaluation and management, as well as guide analgesic management in real time. Disclosures: Tanabe: NIH, and Mayday Fund: Research Funding. Todd: NIH: Research Funding; Xanodyne: Consultancy; Merck: Consultancy; Alpharma: Consultancy; Abbott: Consultancy; Baxter Healthcare: Consultancy; Fralex Therapeutics: Consultancy; Intranasal Therapeutics: Consultancy; Baxter Health: Research Funding; Roxro: Consultancy.
    Type of Medium: Online Resource
    ISSN: 0006-4971 , 1528-0020
    RVK:
    RVK:
    Language: English
    Publisher: American Society of Hematology
    Publication Date: 2009
    detail.hit.zdb_id: 1468538-3
    detail.hit.zdb_id: 80069-7
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  • 3
    In: Blood, American Society of Hematology, Vol. 134, No. Supplement_1 ( 2019-11-13), p. 2113-2113
    Abstract: Introduction: Sickle cell disease (SCD) is a complex disease for which pain is the hallmark. Pain from vaso-occlusive episodes is the number one reason for ED visits and hospital admissions. This paper reports Medicaid claims data from NC for individuals with SCD, including: 1) ED encounters and re-encounters within 7, 14 and 30 days; 2) hospitalization and re-hospitalization within 7, 14 and 30 days; and 3) ED reliance (EDR) score. Methods: We examined Medicaid claims data from for patients with a diagnosis of SCD (ICD 9 CM codes: 282.6x, ICD 10 CM codes: D57.0x, D57.1, D57.2x, D57.4x, D57.8x) in North Carolina. Data is reported for a cohort of 2,790 patients with a diagnosis of SCD, age 1 to 65+ and enrolled at least 11 months in NC Medicaid between March 1, 2016 and February 28, 2017. ED re-encounters and re-hospitalizations within 7, 14 and 30 days were identified using the time between the date of service listed on the ED or hospital claim and the next date of service in the subsequent claim. Individual ED Reliance (EDR) score was calculated as the total number of ED encounters divided by the total ambulatory visits (outpatient + ED encounters) per enrollee, (ambulatory visits reported elsewhere). Similar to Kroner et al, an EDR of 〉 0.33 was considered a high score. Inpatient claims were identified using a category of service code indicating hospitalization. Results: The participants in the sample (n=2790) were majority female (57.92%), lived in metropolitan areas (77.63%) and had a mean age of 23.05 years old (SD=16.06). Of the 9,075 total ED encounters, 69.86% of the total sample had an ED encounter during the 12-month study period. There was a mean of 3.25 (SD=7.38) and median of 1 (IQR = 0 - 3) ED encounters per patient for the sample. Those who were 18-30 years old had the highest mean and median ED encounters per patient (4.98, SD= 9.34 and 2, IQR 1 to 5). The 31-45 year old group had the second most, with 4.82 (SD= 11.03) total ED encounters. The percentage of the sample with an ED re-encounter within 7, 14, and 30 days was also highest among the 18-30 year old group (29.17%, 33.98% and 40.89%) followed by those 31-45 years old (23.71%, 28.49%, and 34.80%), respectively. The 31-45 age group had the second most hospitalizations/patient and re-hospitalizations. The mean EDR was highest among 18-30 year old patients (0.35) and 46.48% of this age group had an EDR of 0.33 or greater. In the 31-45 year-old age group, the mean EDR was 0.28 and 35.18% had an EDR of 0.33 or greater. The overall sample had a mean of 1.30 (SD= 2.75) hospitalizations/patient. The 18-30 year old age group also had the highest mean total hospitalizations (2.08, SD= 3.72) and mean re-hospitalizations within 7 (0.16; SD=0.77), 14 (0.41; SD=1.68), and 30 (0.82; SD=2.79) days. The 31-45 age group had the second most hospitalizations/patient and re-hospitalizations (Table 1). Conclusions: Overall, increasing age coincided with increased ED and inpatient utilization, as well as with the period of transition from pediatric to adult SCD care. Furthermore, high EDR was most prevalent in the 18-30 age group. Our study further supports the need for increased focus on acute care utilization in the 18-45 year-old age group and considerations for improved care transition interventions. Disclosures Tanabe: NIH: Research Funding; AHRQ: Research Funding. Shah:Novartis: Consultancy, Research Funding, Speakers Bureau; Alexion: Speakers Bureau; GBT: Research Funding.
    Type of Medium: Online Resource
    ISSN: 0006-4971 , 1528-0020
    RVK:
    RVK:
    Language: English
    Publisher: American Society of Hematology
    Publication Date: 2019
    detail.hit.zdb_id: 1468538-3
    detail.hit.zdb_id: 80069-7
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  • 4
    In: Academic Emergency Medicine, Wiley, Vol. 14, No. 11 ( 2007-11), p. 1090-1096
    Type of Medium: Online Resource
    ISSN: 1069-6563 , 1553-2712
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2007
    detail.hit.zdb_id: 2029751-8
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  • 5
    Online Resource
    Online Resource
    Wiley ; 2003
    In:  Academic Emergency Medicine Vol. 10, No. 8 ( 2003-08), p. 897-900
    In: Academic Emergency Medicine, Wiley, Vol. 10, No. 8 ( 2003-08), p. 897-900
    Abstract: Objectives: To evaluate simultaneously several possible risk factors for blood bank specimen hemolysis. Methods: This was a prospective cohort study of emergency department and labor and delivery patients to estimate the effect of various factors on the risk of blood bank specimen hemolysis. Study variables included patient demographics, type and gauge of needle or catheter, anatomic location of venipuncture, and patient care area. Hemolysis was determined by blood bank laboratory technicians. Cox proportional hazards multivariate regression modeling was performed to estimate the adjusted relative risks for hemolysis. Results: Of the 605 subjects with complete data, 194 (32.1%) subjects had blood specimens drawn directly with a steel needle, and 411 (69.1%) had specimens drawn through a Vialon (BD Medical Systems, Inc., Sandy, UT) intravenous (IV) angiocatheter. The overall risk of hemolysis for all was 7%, 10% for Vialon IV angiocatheters and 1.5% for steel needles. In the multivariate analysis, the factors most closely associated with hemolysis were the use of Vialon IV catheters and sampling from an anatomic site other than the antecubital area. Conclusions: Blood bank specimens drawn from Vialon IV catheters (particularly smaller gauge catheters) and from veins outside the antecubital area are at significantly increased risk to hemolyze.
    Type of Medium: Online Resource
    ISSN: 1069-6563 , 1553-2712
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2003
    detail.hit.zdb_id: 2029751-8
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  • 6
    Online Resource
    Online Resource
    Wiley ; 2004
    In:  Academic Emergency Medicine Vol. 11, No. 5 ( 2004-05), p. 699-702
    In: Academic Emergency Medicine, Wiley, Vol. 11, No. 5 ( 2004-05), p. 699-702
    Type of Medium: Online Resource
    ISSN: 1069-6563 , 1553-2712
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2004
    detail.hit.zdb_id: 2029751-8
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  • 7
    In: Academic Emergency Medicine, Wiley, Vol. 17, No. 8 ( 2010-07-29), p. 848-858
    Type of Medium: Online Resource
    ISSN: 1069-6563
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2010
    detail.hit.zdb_id: 2029751-8
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  • 8
    Online Resource
    Online Resource
    American Society of Hematology ; 2009
    In:  Blood Vol. 114, No. 22 ( 2009-11-20), p. 241-241
    In: Blood, American Society of Hematology, Vol. 114, No. 22 ( 2009-11-20), p. 241-241
    Abstract: Abstract 241 Study Objectives: To report the patients' ability to make and keep follow-up appointments, obtain analgesic prescriptions, and continued presence of pain for adult emergency department (ED) patients with sickle cell disease, seven and 30 days post ED visit. Barriers to making and keeping appointments and filling analgesic prescriptions were explored. Methods: A multi-center, prospective, longitudinal surveillance study enrolled patients from three academic medical centers (rural and urban). All ED patients ≥18 years with a chief complaint of a sickle cell pain episode were eligible for inclusion. Patients participated in an initial interview within 14 days of their ED visit and/or a second interview 21–37 days from their ED visit. Patients were interviewed at most once per month. The initial interview was conducted either during the hospitalization if admitted, or by follow-up phone call. The 2nd interview was conducted by phone. Pain scores at the time of both interviews were obtained. During the 2nd interview patients were asked if they were able to (1) make and keep a follow-up appointment, (2) whether or not they received and were able to fill an analgesic prescription and (3) associated barriers to either. Each study site conducted a minimum of 10 interviews per quarter. The study period was from October 2007 through July 2009. Descriptive statistics were used to report the data. A paired t-test was used to analyze differences in 7 and 30 day pain scores. Qualitative analysis was used to analyze free text barrier responses to making and keeping an appointment and filling prescriptions. Results: One hundred fifty seven initial interviews and 108 second interviews were completed, 80 different patients, 51% male, mean age 34±10, ages 18–51. Sixty six percent of patients reported they were able to obtain an appointment with a primary care physician after discharge. Of those with difficulty getting an appointment, barriers included: patient did not attempt to obtain an appointment (24%), no current appointments available (21%), difficulty getting a hold of MD office (18%), difficulty finding an MD (15%), no time to go to appointment (9%), lost MD phone number (6%), unspecified (6%), and no money for appointment (3%). Sixty six percent of patients with an appointment reported keeping their appointment or had a future appointment scheduled. Reasons why patients did not keep their appointment included: had to work, out of town, in hospital before appointment, forgot when appointment was, no money for appointment. At discharge from the ED or hospital, 70% of patients reported they needed an analgesic prescription and 66% of patients received a prescription for analgesics. Nineteen percent of patients reported difficulty filling their prescription. Difficulties included: prescription written incorrectly, dose was not available at pharmacy, pharmacy was closed, no money for prescription, homeless. Initial interview pain scores (median, IQR) were 7; (6.25, 8), and 2nd interview pain scores were 8; (7, 9). 57 patients participated in both an initial and follow-up interview and no differences in pain scores were reported, (p=0.83). Forty three percent of patients (who were discharged home from the ED) during the initial interview, and 59% of patients during the 2nd interview reported being unable to manage their pain at home. On the second interview, 74% of patients reported they were currently experiencing sickle cell pain and 72% reported they were taking pain medication every day. Conclusion Many ED patients did not keep follow-up appointments and a smaller number of patients experienced barriers to filling analgesic prescriptions. Over half of patients reported continued pain in the severe range 30 days after the ED visit. Disclosures: Tanabe: NIH, and Mayday Fund: Research Funding. Hafner:Mayday Fund: Research Funding. Martinovich:Mayday Fund: Research Funding. Zvirbulis:Mayday Fund: Research Funding. Artz:Mayday Fund: Research Funding.
    Type of Medium: Online Resource
    ISSN: 0006-4971 , 1528-0020
    RVK:
    RVK:
    Language: English
    Publisher: American Society of Hematology
    Publication Date: 2009
    detail.hit.zdb_id: 1468538-3
    detail.hit.zdb_id: 80069-7
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  • 9
    Online Resource
    Online Resource
    American Society of Hematology ; 2013
    In:  Blood Vol. 122, No. 21 ( 2013-11-15), p. 5579-5579
    In: Blood, American Society of Hematology, Vol. 122, No. 21 ( 2013-11-15), p. 5579-5579
    Abstract: Vaso-occlusive crisis (VOC) management of patients with sickle cell disease (SCD) in emergency departments (EDs) is typically reported as sub-optimal. As part of a larger research and quality improvement study, a nurse-initiated high dose, opioid protocol for adults with VOC was implemented in one ED. The protocol allowed for administration of a total of morphine sulfate (MS) 50 mg, or hydromorphone 10 mg intravenous push (IVP), over three doses (every 20 minutes) and within 60 minutes for patients who received opioid therapy in the last 24 hours, and half the dose for patients who had not taken opioids in the last 24 hours. Additional analgesic administration was at the discretion of the ED physician. Objective Protocol fidelity [total IV MS equivalents (IVMSE) in mgs administered] and safety was evaluated. Methods A structured medical record (MR) review was conducted for all ED visits in patients with a diagnosis of VOC during the 13 month time period immediately after protocol initiation in a single urban ED. All opioids, doses and routes administered during the entire ED stay, and six hours into the hospital admission (when applicable) were abstracted and the total IVMSE administered was calculated for the ED, hospital (First 6 hours), and a total ED + hospital. The period of six hours post admission was selected to be able to identify possible negative effects of opioids administered in the ED; thus it was necessary to also abstract additional opioid doses received by the patient during this six our time period. After six hours, negative effects would not be the result of dosing done in the ED. All documented Oxygen saturations (SPO2) and respiratory rates were abstracted. The ED and hospital MR were searched for administration of naloxone, vasoactive medications, and evidence of respiratory arrest, or any other type of resuscitation effort. A respiratory rate (RR) 〈 10, or SPO2 〈 92 were coded as abnormal. Descriptive statistics were used to report the total IVMSE while in ED, six hours post ED while in the hospital, and total (ED and hospital). Inter-rater reliability of IVMSE doses was good (n=80, Pearson r = .84). Logistic regression was used to predict abnormal events. Predictors in the model were age, gender, and ED IVMSE administered. Results 72 patients (mean age 36, 54% male) had 603 visits, of those 276 were admitted. The total mean (95% CI) mg IVMSE administered in the ED and first 6 hours of hospital combined was 93 mg (CI 86, 100), ED visit 63 mg (CI 59, 67) and hospital 66 mg (CI 59, 72).  No administration of naloxone, vasoactive medications, or resuscitative measures was required during any visit. During two visits, patients experienced a RR 〈 10 and 61 visits were associated with a SPO2 〈 92%. It was not possible to determine if oxygen administration was additionally required because many patients routinely received oxygen during VOC. Older age and higher IVMSE dose were associated with abnormal vital sign occurrence. For every one year increase in age, patients were 4%, or 1.04 times more likely to experience an abnormal vital sign (p=0.012). For every 10 mg IVMSE increase in the ED dose, patients were 4.6%, or 1.046 times more likely to experience an abnormal vital sign (p=0.049). Conclusion A high dose opioid protocol to treat VOC in the ED was found to be feasible, importantly, the protocol was safe. Older age and higher IVMSE dose were associated with abnormal vital sign occurrence.  While some patients experienced a SPO2 〈 92%, no additional interventions or opioids discontinuation were required. Disclosures: No relevant conflicts of interest to declare.
    Type of Medium: Online Resource
    ISSN: 0006-4971 , 1528-0020
    RVK:
    RVK:
    Language: English
    Publisher: American Society of Hematology
    Publication Date: 2013
    detail.hit.zdb_id: 1468538-3
    detail.hit.zdb_id: 80069-7
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  • 10
    Online Resource
    Online Resource
    Ovid Technologies (Wolters Kluwer Health) ; 2021
    In:  The Clinical Journal of Pain Vol. 37, No. 9 ( 2021-09), p. 669-677
    In: The Clinical Journal of Pain, Ovid Technologies (Wolters Kluwer Health), Vol. 37, No. 9 ( 2021-09), p. 669-677
    Abstract: The aim of this study was to identify classes of individuals with sickle cell disease (SCD) who share distinct severe pain profiles and evaluate differences in demographic, clinical, and psychosocial characteristics between classes. Methods: This exploratory, cross-sectional study used data collected for the SCD Implementation Consortium Research Registry at Duke University. Using Adult Sickle Cell Quality of Life-Measurement System pain-item data from 291 adults with SCD, latent class analysis was used to determine classes of individuals sharing distinct severe pain profiles. Bivariate analyses and logistic regression models were used to assess the relationships between pain profile classes and demographic, clinical, and psychosocial characteristics. Results: Three classes sharing distinct severe pain profiles were identified: Low Frequency and Impact class (n=73), Moderate Frequency and Impact class (n=94), and High Frequency and Impact class (n=124). When compared with the Low Frequency and Impact class and controlling for age and sex, individuals in the Moderate Frequency and Impact class were more likely to: be female ( P =0.031) and unemployed ( P =0.013); report worse sleep ( P =0.005) and social functioning ( P =0.005); have less emotional distress ( P =0.004); describe pain as “sore” ( P =0.002); and have previous SCD-related lung complications ( P =0.016). When compared with the Low Frequency and Impact class, individuals in the High Frequency and Impact class: had worse social functioning ( P 〈 0.001) and previous SCD-related lung complications ( P =0.006); described pain as “sore” ( P 〈 0.001); and were taking pain medication daily for SCD ( P =0.001). Discussion: Severe pain experiences in SCD are complex; however, there are subgroups of people who report similar experiences of severe pain.
    Type of Medium: Online Resource
    ISSN: 0749-8047
    RVK:
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2021
    detail.hit.zdb_id: 1497640-7
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