In:
Science Immunology, American Association for the Advancement of Science (AAAS), Vol. 7, No. 78 ( 2022-12-16)
Abstract:
To support increased demands on the immune system in response to infection or inflammation, activation of emergency hematopoiesis stimulates hematopoietic stem cell (HSC) proliferation and myeloid-biased differentiation. Whereas pathogen recognition or inflammatory cytokines are typically involved in initiating this process, Dietlein et al. found that mice lacking the deubiquitinase USP22 in hematopoietic cells spontaneously adopt a state of emergency hematopoiesis in the absence of an infection. H2B monoubiquitination, an activating histone modification, was increased at interferon-stimulated gene (ISG) loci, corresponding to increased ISG expression in USP22-deficient HSCs. USP22-deficient mice were protected against bacterial infection, demonstrating that USP22 cell-intrinsically restrains hematopoietic responses that confer innate immune protection against pathogens.
Type of Medium:
Online Resource
ISSN:
2470-9468
DOI:
10.1126/sciimmunol.abq2061
Language:
English
Publisher:
American Association for the Advancement of Science (AAAS)
Publication Date:
2022
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