In:
PLOS ONE, Public Library of Science (PLoS), Vol. 16, No. 3 ( 2021-3-5), p. e0248193-
Abstract:
We investigated the potential of [ 18 F]fluorodeoxyglucose ([ 18 F]FDG) and [ 18 F]Fluoromethylcholine ([ 18 F]FCho) PET, compared to contrast-enhanced MRI, for the early detection of treatment response in F98 glioblastoma (GB) rats. Methods When GB was confirmed on T2- and contrast-enhanced T1-weighted MRI, animals were randomized into a treatment group (n = 5) receiving MRI-guided 3D conformal arc micro-irradiation (20 Gy) with concomitant temozolomide, and a sham group (n = 5). Effect of treatment was evaluated by MRI and [ 18 F]FDG PET on day 2, 5, 9 and 12 post-treatment and [ 18 F]FCho PET on day 1, 6, 8 and 13 post-treatment. The metabolic tumor volume (MTV) was calculated using a semi-automatic thresholding method and the average tracer uptake within the MTV was converted to a standard uptake value (SUV). Results To detect treatment response, we found that for [ 18 F]FDG PET (SUV mean x MTV) is superior to MTV only. Using (SUV mean x MTV), [ 18 F]FDG PET detects treatment effect starting as soon as day 5 post-therapy, comparable to contrast-enhanced MRI. Importantly, [ 18 F]FDG PET at delayed time intervals (240 min p.i.) was able to detect the treatment effect earlier, starting at day 2 post-irradiation. No significant differences were found at any time point for both the MTV and (SUV mean x MTV) of [ 18 F]FCho PET. Conclusions Both MRI and particularly delayed [ 18 F]FDG PET were able to detect early treatment responses in GB rats, whereas, in this study this was not possible using [ 18 F]FCho PET. Further comparative studies should corroborate these results and should also include (different) amino acid PET tracers.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0248193
DOI:
10.1371/journal.pone.0248193.g001
DOI:
10.1371/journal.pone.0248193.g002
DOI:
10.1371/journal.pone.0248193.g003
DOI:
10.1371/journal.pone.0248193.g004
DOI:
10.1371/journal.pone.0248193.g005
DOI:
10.1371/journal.pone.0248193.g006
DOI:
10.1371/journal.pone.0248193.g007
DOI:
10.1371/journal.pone.0248193.g008
DOI:
10.1371/journal.pone.0248193.t001
DOI:
10.1371/journal.pone.0248193.t002
DOI:
10.1371/journal.pone.0248193.s001
DOI:
10.1371/journal.pone.0248193.s002
DOI:
10.1371/journal.pone.0248193.r001
DOI:
10.1371/journal.pone.0248193.r002
DOI:
10.1371/journal.pone.0248193.r003
DOI:
10.1371/journal.pone.0248193.r004
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2021
detail.hit.zdb_id:
2267670-3
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