In:
EMBO reports, EMBO, Vol. 23, No. 9 ( 2022-09-05)
Kurzfassung:
image The RNA‐binding protein hnRNP R inhibits P‐TEFb‐mediated phosphorylation of RNA polymerase II, thereby modulating transcription. P‐TEFb remodelling and release from 7SK in an hnRNP R‐dependent manner contribute to this effect. Cells lacking hnRNP R show increased transcription accompanied by enhanced phosphorylation of Serine 2 of the C‐terminal domain of RNA polymerase II. Deficiency of hnRNP R induces release of P‐TEFb from the inhibitory non‐coding RNA 7SK. Cyclin T1 is destabilized upon loss of hnRNP R, and Cyclin K interaction with CDK9 is enhanced. Transcriptome alterations overlap in cells lacking hnRNP R or 7SK.
Materialart:
Online-Ressource
ISSN:
1469-221X
,
1469-3178
DOI:
10.15252/embr.202255432
Sprache:
Englisch
Verlag:
EMBO
Publikationsdatum:
2022
ZDB Id:
2025376-X
SSG:
12
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