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Advances and prospects for the Human BioMolecular Atlas Program (HuBMAP)

Jain, Sanjay ; Pei, Liming ; Spraggins, Jeffrey M. ; [weitere]

Springer Science and Business Media LLC ; 2023

In: Nature Cell Biology Vol. 25, No. 8 ( 2023-08), p. 1089-1100

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In: Nature Cell Biology, Springer Science and Business Media LLC, Vol. 25, No. 8 ( 2023-08), p. 1089-1100

Materialart: Online-Ressource

ISSN: 1465-7392 , 1476-4679

URL: Article

DOI: 10.1038/s41556-023-01194-w

Sprache: Englisch

Verlag: Springer Science and Business Media LLC

Publikationsdatum: 2023

ZDB Id: 1494945-3

SSG: 12

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GmJAZ3 interacts with GmRR18a and GmMYC2a to regulate seed traits in soybean

Hu, Yang ; Liu, Yue ; Tao, Jian‐Jun ; [weitere]

Wiley ; 2023

In: Journal of Integrative Plant Biology Vol. 65, No. 8 ( 2023-08), p. 1983-2000

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In: Journal of Integrative Plant Biology, Wiley, Vol. 65, No. 8 ( 2023-08), p. 1983-2000

Kurzfassung: Seed weight is usually associated with seed size and is one of the important agronomic traits that determine yield. Understanding of seed weight control is limited, especially in soybean plants. Here we show that Glycine max JASMONATE‐ZIM DOMAIN 3 ( GmJAZ3) , a gene identified through gene co‐expression network analysis, regulates seed‐related traits in soybean. Overexpression of GmJAZ3 promotes seed size/weight and other organ sizes in stable transgenic soybean plants likely by increasing cell proliferation. GmJAZ3 interacted with both G. max RESPONSE REGULATOR 18a (GmRR18a) and GmMYC2a to inhibit their transcriptional activation of cytokinin oxidase gene G. max CYTOKININ OXIDASE 3‐4 ( GmCKX3‐4 ), which usually affects seed traits. Meanwhile, the GmRR18a binds to the promoter of GmMYC2a and activates GmMYC2a gene expression. In GmJAZ3 ‐overexpressing soybean seeds, the protein contents were increased while the fatty acid contents were reduced compared to those in the control seeds, indicating that the GmJAZ3 affects seed size/weight and compositions. Natural variation in JAZ3 promoter region was further analyzed and Hap3 promoter correlates with higher promoter activity, higher gene expression and higher seed weight. The Hap3 promoter may be selected and fixed during soybean domestication. JAZ3 orthologs from other plants/crops may also control seed size and weight. Taken together, our study reveals a novel molecular module GmJAZ3‐GmRR18a/GmMYC2a‐GmCKXs for seed size and weight control, providing promising targets during soybean molecular breeding for better seed traits.

Materialart: Online-Ressource

ISSN: 1672-9072 , 1744-7909

URL: Issue

URL: Article

DOI: 10.1111/jipb.v65.8

DOI: 10.1111/jipb.13494

Sprache: Englisch

Verlag: Wiley

Publikationsdatum: 2023

ZDB Id: 2130095-1

SSG: 12

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Winter mixing accelerates decomposition of sedimentary organic carbon in seasonally hypoxic coastal seas

Wei, Lin ; Cai, Pinghe ; Shi, Xiangming ; [weitere]

Elsevier BV ; 2022

In: Geochimica et Cosmochimica Acta Vol. 317 ( 2022-01), p. 457-471

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In: Geochimica et Cosmochimica Acta, Elsevier BV, Vol. 317 ( 2022-01), p. 457-471

Materialart: Online-Ressource

ISSN: 0016-7037

URL: Article

DOI: 10.1016/j.gca.2021.11.003

RVK:

TE 1000

Sprache: Englisch

Verlag: Elsevier BV

Publikationsdatum: 2022

ZDB Id: 300305-X

ZDB Id: 1483679-8

SSG: 13

SSG: 16,12

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Image_6.TIF

Cai, Meng ; Chai, Songshan ; Xiong, Tao ; [weitere]

Frontiers Media SA ; 2021

In: Frontiers in Cell and Developmental Biology Vol. 9 ( 2021-8-23)

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In: Frontiers in Cell and Developmental Biology, Frontiers Media SA, Vol. 9 ( 2021-8-23)

Kurzfassung: A group of circulating microRNAs (miRNAs) have been implicated in the pathogenesis of Parkinson’s disease. However, a comprehensive study of the interactions between pathogenic miRNAs and their downstream Parkinson’s disease (PD)-related target genes has not been performed. Here, we identified the miRNA expression profiles in the plasma and circulating exosomes of Parkinson’s disease patients using next-generation RNA sequencing. Kyoto Encyclopedia of Genes and Genomes (KEGG) and Gene Ontology (GO) analyses showed that the miRNA target genes were enriched in axon guidance, neurotrophin signaling, cellular senescence, and the Transforming growth factor-β (TGF-β), mitogen-activated protein kinase (MAPK), phosphatidylinositol 3-kinase (PI3K)-protein kinase B (AKT) and mechanistic target of rapamycin (mTOR) signaling pathways. Furthermore, a group of aberrantly expressed miRNAs were selected and further validated in individual patient plasma, human neural stem cells (NSCs) and a rat model of PD. More importantly, the full scope of the regulatory network between these miRNAs and their PD-related gene targets in human neural stem cells was examined, and the findings revealed a similar but still varied downstream regulatory cascade involving many known PD-associated genes. Additionally, miR-23b-3p was identified as a novel direct regulator of alpha-synuclein, which is possibly the key component in PD. Our current study, for the first time, provides a glimpse into the regulatory network of pathogenic miRNAs and their PD-related gene targets in PD. Moreover, these PD-associated miRNAs may serve as biomarkers and novel therapeutic targets for PD.

Materialart: Online-Ressource

ISSN: 2296-634X

URL: Article

DOI: 10.3389/fcell.2021.695007

DOI: 10.3389/fcell.2021.695007.s001

DOI: 10.3389/fcell.2021.695007.s002

DOI: 10.3389/fcell.2021.695007.s003

DOI: 10.3389/fcell.2021.695007.s004

DOI: 10.3389/fcell.2021.695007.s005

DOI: 10.3389/fcell.2021.695007.s006

Sprache: Unbekannt

Verlag: Frontiers Media SA

Publikationsdatum: 2021

ZDB Id: 2737824-X

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Chemical Composition and Reaction Mechanisms for Aged p ‐Xylene Secondary Organic Aerosol in the Presence of Ammonia

Xu, Jun ; Huang, Ming‐Qiang ; Cai, Shun‐You ; [weitere]

Wiley ; 2018

In: Journal of the Chinese Chemical Society Vol. 65, No. 5 ( 2018-05), p. 578-590

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In: Journal of the Chinese Chemical Society, Wiley, Vol. 65, No. 5 ( 2018-05), p. 578-590

Kurzfassung: A laboratory study was carried out to investigate the chemical composition of aged aromatic secondary organic aerosol (SOA) formed from the photoxidation of p ‐xylene in the presence of ammonia (NH 3 ). The experiments were conducted by irradiating p ‐xylene/CH 3 ONO/NH 3 air mixtures without and with NO in a home‐made smog chamber. The particulate products of aged p ‐ xylene SOA in the presence of NH 3 were measured by UV–vis spectrophotometry, attenuated total reflectance Fourier transform infrared (ATR‐FTIR) spectroscopy, and aerosol laser time‐of‐flight mass spectrometry (ALTOFMS) coupled with the fuzzy C‐means (FCM) clustering algorithm. The experimental results show that NH 3 does not alter the gas–particle partitioning in the photoxidation of p ‐xylene without NO and that 2,5‐dimethylphenol is the predominant NH 3 ‐aged p ‐xylene SOA without NO. However, NH 3 has a significant promotional effect on the formation of organonitrogen compounds in the OH‐initiated oxidation of p ‐xylene with NO. Organic ammonium salts such as ammonium glyoxylate and p ‐methyl ammonium benzoate, which are formed from NH 3 reactions with gaseous organic acids, were detected as the major particulate organonitrogen products of NH 3 ‐aged p ‐xylene SOA with NO. 1 H ‐Imidazole, 4‐methyl‐1 H ‐imidazole, and other imidazole products of the heterogeneous reactions between NH 3 and dialdehydes of p ‐xylene SOA were newly measured. The possible reaction mechanisms leading to these organonitrogen products are also discussed and proposed. The formation of imidazole products suggests that some ambient particles containing organonitrogen compounds may be the result of this mechanism. The results of this study may provide valuable information for discussing anthropogenic SOA aging mechanisms.

Materialart: Online-Ressource

ISSN: 0009-4536 , 2192-6549

URL: Issue

URL: Article

DOI: 10.1002/jccs.2018.65.issue-5

DOI: 10.1002/jccs.201700249

Sprache: Englisch

Verlag: Wiley

Publikationsdatum: 2018

ZDB Id: 2029538-8

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Atorvastatin combined with dexamethasone in chronic subdural haematoma (ATOCH II): study protocol for a randomized controlled trial

Jiang, Rong Cai ; Wang, Dong ; Zhao, Shi Guang ; [weitere]

Springer Science and Business Media LLC ; 2021

In: Trials Vol. 22, No. 1 ( 2021-12)

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In: Trials, Springer Science and Business Media LLC, Vol. 22, No. 1 ( 2021-12)

Kurzfassung: Chronic subdural haematoma (CSDH) is a common condition in the elderly that often requires neurosurgical management. For small CSDH, evidence has emerged that statins may reduce haematoma volume and improve outcomes, presumably by reducing local inflammation and promoting vascular repair. We wish to extend this evidence in a study that aims to determine the efficacy and safety of atorvastatin combined with low-dose dexamethasone in patients with CSDH. Methods The second ATorvastatin On Chronic subdural Hematoma (ATOCH-II) study is a multi-centre, randomized, placebo-controlled, double-blind trial which aims to enrol 240 adult patients with a conservative therapeutic indication for CSDH, randomly allocated to standard treatment with atorvastatin 20 mg combined with low-dose dexamethasone (or matching placebos) daily for 28 days, and with 152 days of follow-up. The primary outcome is a composite good outcome defined by any reduction from baseline in haematoma volume and survival free of surgery at 28 days. Secondary outcomes include functional outcome on the modified Rankin scale (mRS) and modified Barthel Index at 28 days, surgical transition and reduction in haematoma volumes at 14, 28 and 90 days. Discussion This multi-centre clinical trial aims to provide high-quality evidence on the efficacy and safety of the combined treatment of atorvastatin and low-dose dexamethasone to reduce inflammation and enhance angiogenesis in CSDH. Trial registration ChiCTR, ChiCTR1900021659 . Registered on 3 March 2019, http://www.chictr.org.cn/showproj.aspx?proj=36157 .

Materialart: Online-Ressource

ISSN: 1745-6215

URL: Article

DOI: 10.1186/s13063-021-05871-9

Sprache: Englisch

Verlag: Springer Science and Business Media LLC

Publikationsdatum: 2021

ZDB Id: 2040523-6

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Urolithin A exerts antiobesity effects through enhancing adipose tissue thermogenesis in mice

Xia, Bo ; Shi, Xiao Chen ; Xie, Bao Cai ; [weitere]

Public Library of Science (PLoS) ; 2020

In: PLOS Biology Vol. 18, No. 3 ( 2020-3-27), p. e3000688-

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In: PLOS Biology, Public Library of Science (PLoS), Vol. 18, No. 3 ( 2020-3-27), p. e3000688-

Materialart: Online-Ressource

ISSN: 1545-7885

URL: Article

DOI: 10.1371/journal.pbio.3000688

DOI: 10.1371/journal.pbio.3000688.g001

DOI: 10.1371/journal.pbio.3000688.g002

DOI: 10.1371/journal.pbio.3000688.g003

DOI: 10.1371/journal.pbio.3000688.g004

DOI: 10.1371/journal.pbio.3000688.g005

DOI: 10.1371/journal.pbio.3000688.g006

DOI: 10.1371/journal.pbio.3000688.g007

DOI: 10.1371/journal.pbio.3000688.s001

DOI: 10.1371/journal.pbio.3000688.s002

DOI: 10.1371/journal.pbio.3000688.s003

DOI: 10.1371/journal.pbio.3000688.s004

DOI: 10.1371/journal.pbio.3000688.s005

DOI: 10.1371/journal.pbio.3000688.s006

DOI: 10.1371/journal.pbio.3000688.s007

DOI: 10.1371/journal.pbio.3000688.s008

DOI: 10.1371/journal.pbio.3000688.s009

DOI: 10.1371/journal.pbio.3000688.s010

DOI: 10.1371/journal.pbio.3000688.s011

DOI: 10.1371/journal.pbio.3000688.s012

DOI: 10.1371/journal.pbio.3000688.s013

DOI: 10.1371/journal.pbio.3000688.s014

DOI: 10.1371/journal.pbio.3000688.s015

DOI: 10.1371/journal.pbio.3000688.s016

DOI: 10.1371/journal.pbio.3000688.s017

DOI: 10.1371/journal.pbio.3000688.s018

Sprache: Englisch

Verlag: Public Library of Science (PLoS)

Publikationsdatum: 2020

ZDB Id: 2126773-X

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Histopathological and cytopathological findings in minipigs infected with Streptococcus suis serotype 2

Xie, Chun ; Hou, Yi-Xuan ; Zhao, Yu-Ting ; [weitere]

Walter de Gruyter GmbH ; 2014

In: Bulletin of the Veterinary Institute in Pulawy Vol. 58, No. 2 ( 2014-06-01), p. 201-209

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In: Bulletin of the Veterinary Institute in Pulawy, Walter de Gruyter GmbH, Vol. 58, No. 2 ( 2014-06-01), p. 201-209

Kurzfassung: Five pathogen-free miniature pigs (minipigs) were infected with the virulent strain SH08 of Streptococcus suis 2 (SS2) by intramuscular injection. The pigs died consecutively within 72 h after the challenge. An additional five non-infected pigs were euthanised and used as controls. Microstructural observations showed that degeneration, bleeding, congestion, cellular necrosis, and an increase in inflammatory cells were present in all organs and tissues except the brain. Ultrastructural observations revealed mitochondrial vacuolation and malformed or missing cristae, indicating that infection of minipigs with strain SH08 of SS2 can lead to extensive lesions in major internal organs and tissues. The findings also demonstrated that the minipig is a useful model for the study of SS2 infection.

Materialart: Online-Ressource

ISSN: 2300-3235

URL: Article

DOI: 10.2478/bvip-2014-0030

Sprache: Englisch

Verlag: Walter de Gruyter GmbH

Publikationsdatum: 2014

ZDB Id: 2855010-9

ZDB Id: 2238950-7

SSG: 22

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Hepatitis C therapy with interferon-α and ribavirin reduces the CD4 cell count and the total, 2LTR circular and integrated HIV-1 DNA in HIV/HCV co-infected patients

Jiao, Yan-mei ; Weng, Wen-jia ; Gao, Quan-sheng ; [weitere]

Elsevier BV ; 2015

In: Antiviral Research Vol. 118 ( 2015-06), p. 118-122

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In: Antiviral Research, Elsevier BV, Vol. 118 ( 2015-06), p. 118-122

Materialart: Online-Ressource

ISSN: 0166-3542

URL: Article

DOI: 10.1016/j.antiviral.2015.03.011

Sprache: Englisch

Verlag: Elsevier BV

Publikationsdatum: 2015

ZDB Id: 1495861-2

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Chemical analysis of nitro‐aromatic compounds of secondary organic aerosol formed from photooxidation of p‐xylene with NO x

Zhu, Min‐Cong ; Huang, Ming‐Qiang ; Xue, Bing‐Bing ; [weitere]

Wiley ; 2021

In: Journal of the Chinese Chemical Society Vol. 68, No. 9 ( 2021-09), p. 1697-1708

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In: Journal of the Chinese Chemical Society, Wiley, Vol. 68, No. 9 ( 2021-09), p. 1697-1708

Kurzfassung: Nitro‐aromatic compounds (NACs) measured in ambient aerosol are important contributors to brown carbon. Aromatic compounds are expected to be vital precursors of NACs in the presence of NO x in urban atmospheres. NACs of secondary organic aerosol (SOA) formed from photooxidation of p‐xylene with a variety of NO 2 in smog chamber were investigated in this study. NACs were on‐line measured by aerosol laser time‐of‐flight mass spectrometer and verified by off‐line of ultraviolet absorption and electrospray ionization mass spectra. The results show that NO 2 can promote the formation of p‐xylene SOA. Different from the carbonyls detected in p‐xylene SOA without NO 2 , nitrophenols, nitrocatechols, and other NACs via the nitration of phenolic products of p‐xylene are detected as the major components of SOA with NO 2 . The increase of electrophilic nitro groups in SOA strengthens absorption ability. The mass absorption coefficient averaged over 200–600 nm ( 〈 MAC 〉 ) of SOA gradually increased with the increasing of the concentration of NO 2 . The 〈 MAC 〉 of SOA with 1,000 ppb NO 2 was comparable to that of biomass burning organic aerosols. These provided experimental basis for studying the formation mechanism and optics of anthropogenic NACs in the background of high concentration of NO x in Chinese urban atmosphere.

Materialart: Online-Ressource

ISSN: 0009-4536 , 2192-6549

URL: Issue

URL: Article

DOI: 10.1002/jccs.v68.9

DOI: 10.1002/jccs.202100105

Sprache: Englisch

Verlag: Wiley

Publikationsdatum: 2021

ZDB Id: 2029538-8

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