In:
International Journal of Molecular Sciences, MDPI AG, Vol. 23, No. 15 ( 2022-07-24), p. 8149-
Kurzfassung:
Our objective was to determine and optimize the significant parameters affecting mechanical properties and mean fiber diameter (MFD) of a novel GTR/GBR membrane composed of polycaprolactone (PCL) and chicken eggshell membrane (ESM). For this, we prepared electrospun membrane specimens (n = 16) with varying concentrations of PCL, ESM, nano-hydroxyapatite (HAp), and altered electrospinning parameters as generated by DOE++ software. After the determination of MFD and mechanical properties for all specimens, Taguchi orthogonal array L8 design was used to screen significant factors affecting the MFD and mechanical properties. PCL wt%, ESM wt%, HAp wt%, applied voltage (AV), flow rate (FR), and spinneret-collector distance (SCD) were the independent variables investigated. The response variables analyzed were MFD, tensile strength (TS), and elastic modulus. ANOVA outlined ESM wt%, HAp wt%, AV, FR, SCD, and an interactive effect between PCL wt% and AV to be the significant factors affecting modulus values of an electrospun PCL/ESM membrane (p 〈 0.05). Furthermore, concentrations of PCL and ESM were the significant factors affecting MFD (p 〈 0.05) and there were no significant factors affecting the TS values. Optimization using DOE++ software predicted that the maximal TS of 3.125 MPa, modulus of 278.168 MPa, and MFD of 882.75 nm could be achieved.
Materialart:
Online-Ressource
ISSN:
1422-0067
DOI:
10.3390/ijms23158149
Sprache:
Englisch
Verlag:
MDPI AG
Publikationsdatum:
2022
ZDB Id:
2019364-6
SSG:
12
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