In:
PLOS Biology, Public Library of Science (PLoS), Vol. 21, No. 10 ( 2023-10-4), p. e3002315-
Kurzfassung:
To meet the physiological demands of the body, organs need to establish a functional tissue architecture and adequate size as the embryo develops to adulthood. In the liver, uni- and bipotent progenitor differentiation into hepatocytes and biliary epithelial cells (BECs), and their relative proportions, comprise the functional architecture. Yet, the contribution of individual liver progenitors at the organ level to both fates, and their specific proportion, is unresolved. Combining mathematical modelling with organ-wide, multispectral FRaeppli-NLS lineage tracing in zebrafish, we demonstrate that a precise BEC-to-hepatocyte ratio is established (i) fast, (ii) solely by heterogeneous lineage decisions from uni- and bipotent progenitors, and (iii) independent of subsequent cell type–specific proliferation. Extending lineage tracing to adulthood determined that embryonic cells undergo spatially heterogeneous three-dimensional growth associated with distinct environments. Strikingly, giant clusters comprising almost half a ventral lobe suggest lobe-specific dominant-like growth behaviours. We show substantial hepatocyte polyploidy in juveniles representing another hallmark of postembryonic liver growth. Our findings uncover heterogeneous progenitor contributions to tissue architecture-defining cell type proportions and postembryonic organ growth as key mechanisms forming the adult liver.
Materialart:
Online-Ressource
ISSN:
1545-7885
DOI:
10.1371/journal.pbio.3002315
DOI:
10.1371/journal.pbio.3002315.g001
DOI:
10.1371/journal.pbio.3002315.g002
DOI:
10.1371/journal.pbio.3002315.g003
DOI:
10.1371/journal.pbio.3002315.g004
DOI:
10.1371/journal.pbio.3002315.g005
DOI:
10.1371/journal.pbio.3002315.g006
DOI:
10.1371/journal.pbio.3002315.g007
DOI:
10.1371/journal.pbio.3002315.g008
DOI:
10.1371/journal.pbio.3002315.t001
DOI:
10.1371/journal.pbio.3002315.t002
DOI:
10.1371/journal.pbio.3002315.s001
DOI:
10.1371/journal.pbio.3002315.s002
DOI:
10.1371/journal.pbio.3002315.s003
DOI:
10.1371/journal.pbio.3002315.s004
DOI:
10.1371/journal.pbio.3002315.s005
DOI:
10.1371/journal.pbio.3002315.s006
DOI:
10.1371/journal.pbio.3002315.s007
DOI:
10.1371/journal.pbio.3002315.s008
DOI:
10.1371/journal.pbio.3002315.s009
DOI:
10.1371/journal.pbio.3002315.s010
DOI:
10.1371/journal.pbio.3002315.s011
DOI:
10.1371/journal.pbio.3002315.s012
DOI:
10.1371/journal.pbio.3002315.s013
DOI:
10.1371/journal.pbio.3002315.r001
DOI:
10.1371/journal.pbio.3002315.r002
DOI:
10.1371/journal.pbio.3002315.r003
DOI:
10.1371/journal.pbio.3002315.r004
DOI:
10.1371/journal.pbio.3002315.r005
DOI:
10.1371/journal.pbio.3002315.r006
Sprache:
Englisch
Verlag:
Public Library of Science (PLoS)
Publikationsdatum:
2023
ZDB Id:
2126773-X
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