In:
PLOS Computational Biology, Public Library of Science (PLoS), Vol. 17, No. 12 ( 2021-12-8), p. e1009658-
Kurzfassung:
RNA-binding proteins (RBPs) can regulate more than a single aspect of RNA metabolism. We searched for such previously undiscovered multifunctionality within a set of 143 RBPs, by defining the predictive value of RBP abundance for the transcription and translation levels of known RBP target genes across 80 human hearts. This led us to newly associate 27 RBPs with cardiac translational regulation in vivo . Of these, 21 impacted both RNA expression and translation, albeit for virtually independent sets of target genes. We highlight a subset of these, including G3BP1, PUM1, UCHL5, and DDX3X, where dual regulation is achieved through differential affinity for target length, by which separate biological processes are controlled. Like the RNA helicase DDX3X, the known splicing factors EFTUD2 and PRPF8—all identified as multifunctional RBPs by our analysis—selectively influence target translation rates depending on 5’ UTR structure. Our analyses identify dozens of RBPs as being multifunctional and pinpoint potential novel regulators of translation, postulating unanticipated complexity of protein-RNA interactions at consecutive stages of gene expression.
Materialart:
Online-Ressource
ISSN:
1553-7358
DOI:
10.1371/journal.pcbi.1009658
DOI:
10.1371/journal.pcbi.1009658.g001
DOI:
10.1371/journal.pcbi.1009658.g002
DOI:
10.1371/journal.pcbi.1009658.g003
DOI:
10.1371/journal.pcbi.1009658.g004
DOI:
10.1371/journal.pcbi.1009658.s001
DOI:
10.1371/journal.pcbi.1009658.s002
DOI:
10.1371/journal.pcbi.1009658.s003
DOI:
10.1371/journal.pcbi.1009658.s004
DOI:
10.1371/journal.pcbi.1009658.s005
DOI:
10.1371/journal.pcbi.1009658.s006
DOI:
10.1371/journal.pcbi.1009658.s007
DOI:
10.1371/journal.pcbi.1009658.s008
DOI:
10.1371/journal.pcbi.1009658.s009
DOI:
10.1371/journal.pcbi.1009658.s010
DOI:
10.1371/journal.pcbi.1009658.s011
DOI:
10.1371/journal.pcbi.1009658.r001
DOI:
10.1371/journal.pcbi.1009658.r002
DOI:
10.1371/journal.pcbi.1009658.r003
DOI:
10.1371/journal.pcbi.1009658.r004
Sprache:
Englisch
Verlag:
Public Library of Science (PLoS)
Publikationsdatum:
2021
ZDB Id:
2193340-6
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