In:
The American Journal of Chinese Medicine, World Scientific Pub Co Pte Ltd, Vol. 29, No. 01 ( 2001-01), p. 173-180
Kurzfassung:
We isolated the phenolic compounds epicatechin, catechin, procyanidin B-1, procyanidin B-2, hyperin and caffeic acid from the hooks and stems of Uncaria sinensis (HSUS), and studied their protective effects against glutamate-induced neuronal death in cultured rat cerebellar granule cells. Cell viability evaluated by MTT assay was significantly increased by application of epicatechin (100–300 μM), catechin (300 μM), procyanidin B-1 (30–300 μM) and procyanidin B-2 (100–300 μM) compared with exposure to glutamate only. 45 Ca 2+ influx into cells induced by glutamate was also significantly inhibited by administration of epicatechin (300 μM), catechin (300 μM), procyanidin B-1 (100–300 μM) and procyanidin B-2 (100–300 μM). These results suggest that epicatechin, catechin, procyanidin B-1 and procyanidin B-2 are the active components of HSUS that protect against glutamate-induced neuronal death in cultured cerebellar granule cells by inhibition of Ca 2+ influx.
Materialart:
Online-Ressource
ISSN:
0192-415X
,
1793-6853
DOI:
10.1142/S0192415X01000198
Sprache:
Englisch
Verlag:
World Scientific Pub Co Pte Ltd
Publikationsdatum:
2001
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