In:
Communications Biology, Springer Science and Business Media LLC, Vol. 4, No. 1 ( 2021-02-03)
Kurzfassung:
Iron is essential for many biological functions and iron deficiency and overload have major health implications. We performed a meta-analysis of three genome-wide association studies from Iceland, the UK and Denmark of blood levels of ferritin ( N = 246,139), total iron binding capacity ( N = 135,430), iron ( N = 163,511) and transferrin saturation ( N = 131,471). We found 62 independent sequence variants associating with iron homeostasis parameters at 56 loci, including 46 novel loci. Variants at DUOX2 , F5 , SLC11A2 and TMPRSS6 associate with iron deficiency anemia, while variants at TF , HFE , TFR2 and TMPRSS6 associate with iron overload. A HBS1L-MYB intergenic region variant associates both with increased risk of iron overload and reduced risk of iron deficiency anemia. The DUOX2 missense variant is present in 14% of the population, associates with all iron homeostasis biomarkers, and increases the risk of iron deficiency anemia by 29%. The associations implicate proteins contributing to the main physiological processes involved in iron homeostasis: iron sensing and storage, inflammation, absorption of iron from the gut, iron recycling, erythropoiesis and bleeding/menstruation.
Materialart:
Online-Ressource
ISSN:
2399-3642
DOI:
10.1038/s42003-020-01575-z
Sprache:
Englisch
Verlag:
Springer Science and Business Media LLC
Publikationsdatum:
2021
ZDB Id:
2919698-X
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