In:
Molecular Oncology, Wiley, Vol. 9, No. 6 ( 2015-06), p. 1106-1119
Kurzfassung:
A combination of in vitro findings and breast cancer patient data analysis uncovers the mechanism of gene regulation by miR‐30c‐2‐3p. miR‐30c‐2‐3p expression is lower in the ER negative subtypes, which are associated with active NF‐κB signaling and a more aggressive physiology. miR‐30c‐2‐3p directly targets TRADD and CCNE1, leading to reduced cytokine expression, cell invasion, as well as cell proliferation in vitro.
Materialart:
Online-Ressource
ISSN:
1574-7891
,
1878-0261
DOI:
10.1016/j.molonc.2015.01.008
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
2015
ZDB Id:
2322586-5
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