In:
PLOS Pathogens, Public Library of Science (PLoS), Vol. 19, No. 5 ( 2023-5-17), p. e1011384-
Abstract:
Malayan pangolin SARS-CoV-2-related coronavirus (SARSr-CoV-2) is closely related to SARS-CoV-2. However, little is known about its pathogenicity in pangolins. Using CT scans we show that SARSr-CoV-2 positive Malayan pangolins are characterized by bilateral ground-glass opacities in lungs in a similar manner to COVID-19 patients. Histological examination and blood gas tests are indicative of dyspnea. SARSr-CoV-2 infected multiple organs in pangolins, with the lungs the major target, and histological expression data revealed that ACE2 and TMPRSS2 were co-expressed with viral RNA. Transcriptome analysis indicated that virus-positive pangolins were likely to have inadequate interferon responses, with relative greater cytokine and chemokine activity in the lung and spleen. Notably, both viral RNA and viral proteins were detected in three pangolin fetuses, providing initial evidence for vertical virus transmission. In sum, our study outlines the biological framework of SARSr-CoV-2 in pangolins, revealing striking similarities to COVID-19 in humans.
Type of Medium:
Online Resource
ISSN:
1553-7374
DOI:
10.1371/journal.ppat.1011384
DOI:
10.1371/journal.ppat.1011384.g001
DOI:
10.1371/journal.ppat.1011384.g002
DOI:
10.1371/journal.ppat.1011384.g003
DOI:
10.1371/journal.ppat.1011384.g004
DOI:
10.1371/journal.ppat.1011384.s001
DOI:
10.1371/journal.ppat.1011384.s002
DOI:
10.1371/journal.ppat.1011384.s003
DOI:
10.1371/journal.ppat.1011384.s004
DOI:
10.1371/journal.ppat.1011384.s005
DOI:
10.1371/journal.ppat.1011384.s006
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2023
detail.hit.zdb_id:
2205412-1
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