In:
Harran Üniversitesi Tıp Fakültesi Dergisi, Harran Universitesi Tip Fakultesi Dergisi, Vol. 19, No. 1 ( 2022-04-28), p. 126-130
Abstract:
Background: Corona virus disease (COVID 19) is a global public health problem that has killed more than 4.5 million people. In this study, it was aimed to evaluate the relationship between the thiol and ischemia modified albumin (İMA) levels of COVID-19 patients treated in the inpatient and intensive care unit with their current clinical status and the course of the disease.
Materials and Methods: In this study, 300 patients who were confirmed to be positive by PCR test and diagnosed with COVID-19 infection were included. The patients were divided into two groups based on the unit they were treated. 160 of these patients were treated in the inpatient service (group 1) and 140 in the intensive care units (group 2). Thiol, İMA, CRP and ferritin levels were measured from the serum samples of the patients. Results: When the groups were compared, the thiol levels of group 2 were found to be significantly lower (p & lt;0.001). In addition, it was observed that the İMA levels of group 2 were significantly higher than group 1 (p & lt;0.001). When other laboratory tests were evaluated, the CRP and ferritin levels of group 2 were high (p & lt;0.001) and the lymphocyte count was low (p & lt;0.001). A significant correlation was found between thiol levels and CRP, ferritin, lymphocyte and İMA levels (r=-0.58; p & lt;0.001, r=-0.41; p & lt;0.001, r=-0.32; p & lt;0.001, r=-0.39; p & lt;0.001, respectively).). In addition, a significant correlation was observed between İMA levels and CRP, ferritin, lymphocyte and thiol levels (r=0.19; p=0.02, r=0.18; p=0.043, r=-0.15; p=0.047, r=-0.39; p & lt;0.001, respectively).
Conclusions: The decrease in the level of thiol, which is a powerful antioxidant, in COVID-19 patients suggests that although it is due to the existing inflammatory process that causes oxidative stress, it may also be caused by the effect of oxidative stress due to ischemic conditions developing secondary to thrombosis. Therefore, the increase in İMA levels in intensive care patients in whom the inflammatory process and thrombotic events are observed more severely supports the decrease in thiol levels. As a result, the determination of thiol and İMA levels of COVID-19 patients treated in the inpatient and intensive care unit suggests that it has the potential to help with the current clinical status of the patients and the course of the disease.
Type of Medium:
Online Resource
ISSN:
1304-9623
DOI:
10.35440/hutfd.1068150
Language:
Unknown
Publisher:
Harran Universitesi Tip Fakultesi Dergisi
Publication Date:
2022
detail.hit.zdb_id:
2555262-4
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