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Pediatric COVID-19 and the Factors That May Mitigate Its Clinical Course

Abdel-Aziz, Mosaad ; Abdel-Aziz, Nada M. ; Abdel-Aziz, Dina M. ; [et al.]

Georg Thieme Verlag KG ; 2020

In: Journal of Child Science Vol. 10, No. 01 ( 2020-01), p. e137-e140

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In: Journal of Child Science, Georg Thieme Verlag KG, Vol. 10, No. 01 ( 2020-01), p. e137-e140

Abstract: The clinical manifestations of novel coronavirus disease 2019 (COVID-19) vary from mild flu-like symptoms to severe fatal pneumonia. However, children with COVID-19 may be asymptomatic or may have mild clinical symptoms. The aim of this study was to investigate clinical features of pediatric COVID-19 and to search for the factors that may mitigate the disease course. We reviewed the literature to realize the clinical features, laboratory, and radiographic data that may be diagnostic for COVID-19 among children. Also, we studied the factors that may affect the clinical course of the disease. Fever, dry cough, and fatigue are the main symptoms of pediatric COVID-19, sometimes flu-like symptoms and/or gastrointestinal symptoms may be present. Although some infected children may be asymptomatic, a recent unusual hyperinflammatory reaction with overlapping features of Kawasaki's disease and toxic shock syndrome in pediatric COVID-19 has been occasionally reported. Severe acute respiratory syndrome-coronvirus-2 (SARS-CoV-2) nucleic acid testing is the corner-stone method for the diagnosis of COVID-19. Lymphocyte count and other inflammatory markers are not essentially diagnostic; however, chest computed tomography is highly specific. Factors that may mitigate the severity of pediatric COVID-19 are home confinement with limited children activity, trained immunity caused by compulsory vaccination, the response of the angiotensin-converting enzyme 2 receptors in children is not the same as in adults, and that children are less likely to have comorbidities. As infected children may be asymptomatic or may have only mild respiratory and/or gastrointestinal symptoms that might be missed, all children for families who have a member diagnosed with COVID-19 should be investigated.

Type of Medium: Online Resource

ISSN: 2474-5871

URL: Article

DOI: 10.1055/s-0040-1717077

Language: English

Publisher: Georg Thieme Verlag KG

Publication Date: 2020

detail.hit.zdb_id: 2913205-8

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Mucormycosis: A potential head and neck problem in COVID ‐19 patients

Abdel‐Aziz, Mosaad ; Azab, Noha ; Abdel‐Aziz, Nada M. ; [et al.]

Wiley ; 2022

In: Laryngoscope Investigative Otolaryngology Vol. 7, No. 1 ( 2022-02), p. 67-69

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In: Laryngoscope Investigative Otolaryngology, Wiley, Vol. 7, No. 1 ( 2022-02), p. 67-69

Type of Medium: Online Resource

ISSN: 2378-8038 , 2378-8038

URL: Issue

URL: Article

DOI: 10.1002/lio2.v7.1

DOI: 10.1002/lio2.727

Language: English

Publisher: Wiley

Publication Date: 2022

detail.hit.zdb_id: 2851702-7

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Subjective Smell Assessment as An Office-based Rapid Procedure In COVID-19 Era

Abdel-Aziz, Mosaad ; Abdel-Aziz, Nada M. ; Abdel-Aziz, Dina M. ; [et al.]

Ovid Technologies (Wolters Kluwer Health) ; 2021

In: Journal of Craniofacial Surgery Vol. 32, No. 5 ( 2021-07), p. e439-e441

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In: Journal of Craniofacial Surgery, Ovid Technologies (Wolters Kluwer Health), Vol. 32, No. 5 ( 2021-07), p. e439-e441

Abstract: A recent history of smell disorder may be a potential predictor for COVID-19. The authors used a subjective olfaction score that was demonstrated on a hard paper-bar. The authors examined 480 patients who were attending the outpatient clinic. Ninety-seven patients (20.2%) demonstrated variable degrees of recent smell disorder. For those patients, lab testing including nasopharyngeal swab for real-time polymerase chain reaction (RT-PCR) was performed. Eighty-eight of them (90.7%) have been confirmed to be COVID-19 positive. Although psychophysical testing is more reliable, subjective assessment of smell is a rapid procedure and can be used as an office-based method for patients’ screening in COVID-19 era. Smell disorder could be an alarming sign for COVID-19 even with absent characteristic symptoms.

Type of Medium: Online Resource

ISSN: 1049-2275 , 1536-3732

URL: Article

DOI: 10.1097/SCS.0000000000007245

Language: English

Publisher: Ovid Technologies (Wolters Kluwer Health)

Publication Date: 2021

detail.hit.zdb_id: 2060546-8

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Furlow Palatoplasty and Tonsillectomy for Treating Patients With Submucous Cleft Palate and Tonsillar Hypertrophy: A One-Stage Procedure

Abdel-Aziz, Mosaad ; Abdel-Fattah, Gamal ; Abdel-Aziz, Nada M. ; [et al.]

Ovid Technologies (Wolters Kluwer Health) ; 2023

In: Journal of Craniofacial Surgery Vol. 34, No. 1 ( 2023-01), p. e74-e78

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In: Journal of Craniofacial Surgery, Ovid Technologies (Wolters Kluwer Health), Vol. 34, No. 1 ( 2023-01), p. e74-e78

Abstract: Children with cleft palate are more liable to have obstructive sleep apnea than children with normal palate due to narrow airways. Tonsillar hypertrophy is a common cause of pediatric obstructive sleep apnea; hence, it is not surprising to be encountered during cleft palate repair. The aim of this study was to evaluate the feasibility of tonsillectomy and Furlow palatoplasty performed as a 1-stage operation in patients presenting with submucous cleft palate (SMCP) and tonsillar hypertrophy. Materials and Methods: Eleven pediatric patients with SMCP and hypertrophied tonsils were included in this case series study. Furlow palatoplasty and tonsillectomy were performed for the patients in 1 sitting. The evaluation of velopharyngeal function was done preoperatively and postoperatively via auditory-perceptual-assessment, nasometry, and flexible nasopharyngoscopy. In addition, the Epworth sleepiness scale for children/adolescents was administered to the parents to assess daytime sleepiness of their children. Results: The speech improved postoperatively. Auditory-perceptual-assessment showed significant reductions in hypernasal speech, nasal air escape, and weak pressure consonants. In addition, nasometry revealed significantly decreased nasalance scores for nasal and oral sentences. A postoperative increased velar movement was observed with a significant improvement in velopharyngeal closure. The preoperative Epworth sleepiness scale for children/adolescents assessment revealed excessive daytime sleepiness in 8 patients, with significant improvement of scores postoperatively. Conclusions: Removal of hypertrophied tonsils during the repair of SMCP with Furlow palatoplasty did not negatively affect speech outcome or velar movement postoperatively. It is logical to perform both procedures simultaneously in 1 sitting to avoid postoperative sleep-related breathing disorder, which may necessitate a second stage operation.

Type of Medium: Online Resource

ISSN: 1049-2275

URL: Article

DOI: 10.1097/SCS.0000000000008732

Language: English

Publisher: Ovid Technologies (Wolters Kluwer Health)

Publication Date: 2023

detail.hit.zdb_id: 2060546-8

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Nasopharyngeal Polyp in a Patient With Submucous Cleft Palate

Abdel-Aziz, Mosaad ; Abdel-Fattah, Gamal ; Abdel-Aziz, Nada M

Springer Science and Business Media LLC ; 2021

In: Cureus

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In: Cureus, Springer Science and Business Media LLC

Type of Medium: Online Resource

ISSN: 2168-8184

URL: Article

DOI: 10.7759/cureus.14787

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2021

detail.hit.zdb_id: 2747273-5

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Study of the Efficacy of Indocyanine Green Enhanced Transpupillary Thermotherapy as a Treatment Modality for Retinoblastoma

Aziz, Nada Abdel Salam Abdel ; El Barbary, Magdy Mohamed ; Ziko, Othman Ali Othman ; [et al.]

Oxford University Press (OUP) ; 2023

In: QJM: An International Journal of Medicine Vol. 116, No. Supplement_1 ( 2023-08-23)

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In: QJM: An International Journal of Medicine, Oxford University Press (OUP), Vol. 116, No. Supplement_1 ( 2023-08-23)

Abstract: Retinoblastoma represents approximately 4% of all pediatric malignancies and is the most common ocular malignancy in children. It has one of the highest survival rates among all pediatric malignancies owing to improving treatment methods over the years. Objectives The purpose of our work was to evaluate the efficacy of intravenous indocyanine green dye injection combined with diode laser transpupillary thermotherapy (TTT) as a treatment modality for Group (B) intraocular retinoblastoma compared to the standard protocol of treatment. Patients and Methods A prospective interventional comparative study was conducted in the Ocular Oncology Clinic, Ophthalmic Department, Ain Shams University Hospital in the period from August 2017 to December 2020. The study was conducted on twenty tumors, classified as Group (B) retinoblastoma according to International Classification of Intraocular Retinoblastoma (ICRB). It includes; Tumors & gt;3 mm (in basal dimension or thickness), tumors located in the macula (≤3 mm to foveola), juxta-papillary tumors (≤1.5 mm to disc) or tumors surrounded by subretinal fluid (≤5 mm from the tumor margin). They were divided into two main groups: Group I: It included ten (10) tumors; newly diagnosed or recurrent. This group was treated with systemic chemotherapy plus ICG enhanced diode laser TTT, Group II (control group): It included ten (10) tumors; newly diagnosed or recurrent. This group was treated with systemic chemotherapy plus conventional diode laser TTT. Results The study found that ICG has significantly improved uptake of diode laser, eliminating the need for increasing the laser power to the photocoagulation levels which would disrupt the inner retinal layers. ICG-TTT allowed rapid tumor regression and decreased the number of laser sessions needed to achieve tumor regression.ICG-TTT was successful with 3 challenging recurrent masses on a hypopigmented scar and achieved complete regression. There was no statistically significant difference between the two groups as regards the disease-free survival curves using Kaplan Meier analysis. During the period of post chemotherapy follow up, 3 tumors in Group I (30%) and 2 tumors in group II (20%) developed recurrence. And one case in group I (10%) developed a new mass in a remote site. Conclusion The study concluded that ICG-TTT is both efficient and safe despite some potential complications.

Type of Medium: Online Resource

ISSN: 1460-2725 , 1460-2393

URL: Article

DOI: 10.1093/qjmed/hcad069.586

Language: English

Publisher: Oxford University Press (OUP)

Publication Date: 2023

detail.hit.zdb_id: 1492613-1

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Immunogenicity and Protective Capacity of Schistosoma haematobium Recombinant cathepsin L Against Infection of Hamsters with S. haematobium

Abdel Aziz, Nada ; Faculty ofSCience, Cairo University ; Tallima, Hatem ; [et al.]

CMV Verlag ; 2019

In: Vaccine Research Vol. 6, No. 2 ( 2019-12-01), p. 1-8

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In: Vaccine Research, CMV Verlag, Vol. 6, No. 2 ( 2019-12-01), p. 1-8

Type of Medium: Online Resource

ISSN: 2383-2819 , 2423-4923

URL: Article

DOI: 10.29252/vacres.6.2.1

Language: English

Publisher: CMV Verlag

Publication Date: 2019

detail.hit.zdb_id: 3033242-4

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Host regulation of liver fibroproliferative pathology during experimental schistosomiasis via interleukin-4 receptor alpha

Nono, Justin Komguep ; Ndlovu, Hlumani ; Aziz, Nada Abdel ; [et al.]

Public Library of Science (PLoS) ; 2017

In: PLOS Neglected Tropical Diseases Vol. 11, No. 8 ( 2017-8-21), p. e0005861-

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In: PLOS Neglected Tropical Diseases, Public Library of Science (PLoS), Vol. 11, No. 8 ( 2017-8-21), p. e0005861-

Type of Medium: Online Resource

ISSN: 1935-2735

URL: Article

DOI: 10.1371/journal.pntd.0005861

DOI: 10.1371/journal.pntd.0005861.g001

DOI: 10.1371/journal.pntd.0005861.g002

DOI: 10.1371/journal.pntd.0005861.g003

DOI: 10.1371/journal.pntd.0005861.g004

DOI: 10.1371/journal.pntd.0005861.g005

DOI: 10.1371/journal.pntd.0005861.g006

DOI: 10.1371/journal.pntd.0005861.g007

DOI: 10.1371/journal.pntd.0005861.s001

DOI: 10.1371/journal.pntd.0005861.s002

DOI: 10.1371/journal.pntd.0005861.s003

DOI: 10.1371/journal.pntd.0005861.s004

DOI: 10.1371/journal.pntd.0005861.s005

DOI: 10.1371/journal.pntd.0005861.s006

DOI: 10.1371/journal.pntd.0005861.s007

DOI: 10.1371/journal.pntd.0005861.s008

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2017

detail.hit.zdb_id: 2429704-5

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Interleukin-4 receptor alpha is still required after Th2 polarization for the maintenance and the recall of protective immunity to Nematode infection

Nono, Justin Komguep ; Ndlovu, Hlumani ; Abdel Aziz, Nada ; [et al.]

Public Library of Science (PLoS) ; 2017

In: PLOS Neglected Tropical Diseases Vol. 11, No. 6 ( 2017-6-26), p. e0005675-

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In: PLOS Neglected Tropical Diseases, Public Library of Science (PLoS), Vol. 11, No. 6 ( 2017-6-26), p. e0005675-

Type of Medium: Online Resource

ISSN: 1935-2735

URL: Article

DOI: 10.1371/journal.pntd.0005675

DOI: 10.1371/journal.pntd.0005675.g001

DOI: 10.1371/journal.pntd.0005675.g002

DOI: 10.1371/journal.pntd.0005675.g003

DOI: 10.1371/journal.pntd.0005675.g004

DOI: 10.1371/journal.pntd.0005675.s001

DOI: 10.1371/journal.pntd.0005675.s002

DOI: 10.1371/journal.pntd.0005675.s003

DOI: 10.1371/journal.pntd.0005675.s004

DOI: 10.1371/journal.pntd.0005675.s005

DOI: 10.1371/journal.pntd.0005675.s006

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2017

detail.hit.zdb_id: 2429704-5

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Protective immune responses against Schistosoma mansoni infection by immunization with functionally active gut-derived cysteine peptidases alone and in combination with glyceraldehyde 3-phosphate dehydrogenase

Tallima, Hatem ; Dvořák, Jan ; Kareem, Sahira ; [et al.]

Public Library of Science (PLoS) ; 2017

In: PLOS Neglected Tropical Diseases Vol. 11, No. 3 ( 2017-3-27), p. e0005443-

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In: PLOS Neglected Tropical Diseases, Public Library of Science (PLoS), Vol. 11, No. 3 ( 2017-3-27), p. e0005443-

Type of Medium: Online Resource

ISSN: 1935-2735

URL: Article

DOI: 10.1371/journal.pntd.0005443

DOI: 10.1371/journal.pntd.0005443.g001

DOI: 10.1371/journal.pntd.0005443.g002

DOI: 10.1371/journal.pntd.0005443.g003

DOI: 10.1371/journal.pntd.0005443.g004

DOI: 10.1371/journal.pntd.0005443.g005

DOI: 10.1371/journal.pntd.0005443.g006

DOI: 10.1371/journal.pntd.0005443.g007

DOI: 10.1371/journal.pntd.0005443.g008

DOI: 10.1371/journal.pntd.0005443.t001

DOI: 10.1371/journal.pntd.0005443.t002

DOI: 10.1371/journal.pntd.0005443.s001

DOI: 10.1371/journal.pntd.0005443.s002

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2017

detail.hit.zdb_id: 2429704-5

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