In:
Science, American Association for the Advancement of Science (AAAS), Vol. 340, No. 6138 ( 2013-06-14), p. 1294-1295
Abstract:
Cells have numerous channels and transporters that facilitate movement of specific molecules and ions across biological membranes. However, it is unclear how these proteins facilitate the rapid passage of specific ions while impeding other, often very similar, substrates. The mechanism by which potassium ions (K + ) are transported through K + channels was revealed more than a decade ago ( 1 – 4 ). Computer simulations mirrored the x-ray data, demonstrating the complementary nature of the two techniques. On page 1346 of this issue, Kosinska Eriksson et al. ( 5 ) report the crystal structure of yeast aquaporin1 at subangstrom resolution in conjunction with molecular dynamics simulations, revealing that, much like K + in K + channels, water flows through the aquaporin channel in a pairwise manner.
Type of Medium:
Online Resource
ISSN:
0036-8075
,
1095-9203
DOI:
10.1126/science.1239270
Language:
English
Publisher:
American Association for the Advancement of Science (AAAS)
Publication Date:
2013
detail.hit.zdb_id:
128410-1
detail.hit.zdb_id:
2066996-3
detail.hit.zdb_id:
2060783-0
SSG:
11
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