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  • 1
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    Online Resource
    A new chapter in the field of memory: adult hippocampal neurogenesis
    Wiley ; 2011
    In:  European Journal of Neuroscience Vol. 33, No. 6 ( 2011-03), p. 1101-1114
    Details
    In: European Journal of Neuroscience, Wiley, Vol. 33, No. 6 ( 2011-03), p. 1101-1114
    Abstract: Understanding the cellular mechanisms underlying learning and memory is a major challenge in neurobiology. Structural and functional changes occurring in the hippocampus such as synaptic remodeling and long‐term potentiation are key signatures of long‐term memory processes. The discovery of a de novo hippocampal production of neurons in the adult brain has been a breakthrough in the field of plasticity and memory, introducing a new actor that could sustain memory processes. Here we will review our current knowledge on the role of these adult new neurons in memory. In particular we will provide evidence showing that they are required for learning and memory and that an alteration in their production rate or maturation leads to memory impairments. Through a thorough survey of the literature, we will also acknowledge that there are many controversies regarding the specific role played by newborn neurons. The emerging picture is that they are involved in the establishment of spatiotemporal relationships among multiple environmental cues for the flexible use of the acquired information. Indeed, newborn neurons have been found to be required for separating events based on their spatial and temporal characteristics, a process that preserves the uniqueness of a memory representation. Thus, adult‐born neurons are required for allocentric space representation, for long‐term memory retention and for flexible inferential memory expression. Finally, we will conclude by highlighting directions for future research, emphasizing that the exact participation of newborn neurons in memory processes will not be approached without considering the hippocampal network in general.
    Type of Medium: Online Resource
    ISSN: 0953-816X , 1460-9568
    URL: Issue
    URL: Article
    DOI: 10.1111/ejn.2011.33.issue-6
    DOI: 10.1111/j.1460-9568.2011.07609.x
    Language: English
    Publisher: Wiley
    Publication Date: 2011
    detail.hit.zdb_id: 2005178-5
    SSG: 12
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  • 2
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    Online Resource
    Age‐dependent effect of prenatal stress on hippocampal cell proliferation in female rats
    Wiley ; 2009
    In:  European Journal of Neuroscience Vol. 29, No. 3 ( 2009-02), p. 635-640
    Details
    In: European Journal of Neuroscience, Wiley, Vol. 29, No. 3 ( 2009-02), p. 635-640
    Abstract: Stressors occurring during pregnancy can alter the developmental trajectory of offspring and lead to, among other deleterious effects, cognitive deficits and hyperactivity of the hypothalamo‐pituitary‐adrenal axis. A recent feature of the prenatal stress (PS) model is its reported influence on structural plasticity in hippocampal formation, which sustains both cognitive functions and stress responsiveness. Indeed, we and others have previously reported that males exposed to stress in utero are characterized by a decrease in hippocampal cell proliferation, and consequently neurogenesis, from adolescence to senescence. Recent studies in females submitted to PS have reported conflicting results, ranging from no effect to a decrease in cell proliferation. We hypothesized that changes in cell proliferation in PS female rats are age dependent. To address this issue, we examined the impact of PS on hippocampal cell proliferation in juvenile, young, middle‐aged and old females. As hypothesized, we found an age‐dependent effect of PS in female rats as cell proliferation was significantly decreased only when animals reached senescence, a time when adrenal gland weight also increased. These data suggest that the deleterious effects of PS on hippocampal cell proliferation in females are either specific to senescence or masked during adulthood by protective factors.
    Type of Medium: Online Resource
    ISSN: 0953-816X , 1460-9568
    URL: Issue
    URL: Article
    DOI: 10.1111/ejn.2009.29.issue-3
    DOI: 10.1111/j.1460-9568.2009.06608.x
    Language: English
    Publisher: Wiley
    Publication Date: 2009
    detail.hit.zdb_id: 2005178-5
    SSG: 12
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  • 3
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    Online Resource
    CB1 receptor deficiency decreases wheel-running activity: Consequences on emotional behaviours and hippocampal neurogenesis
    Elsevier BV ; 2010
    In:  Experimental Neurology Vol. 224, No. 1 ( 2010-7), p. 106-113
    Details
    In: Experimental Neurology, Elsevier BV, Vol. 224, No. 1 ( 2010-7), p. 106-113
    Type of Medium: Online Resource
    ISSN: 0014-4886
    URL: Article
    DOI: 10.1016/j.expneurol.2010.01.017
    RVK:
    XA 10000
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2010
    detail.hit.zdb_id: 1466932-8
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  • 4
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    Adult‐born dentate neurons are recruited in both spatial memory encoding and retrieval
    Wiley ; 2015
    In:  Hippocampus Vol. 25, No. 11 ( 2015-11), p. 1472-1479
    Details
    In: Hippocampus, Wiley, Vol. 25, No. 11 ( 2015-11), p. 1472-1479
    Abstract: Adult neurogenesis occurs in the dentate gyrus (DG) of the hippocampus, which is a key structure in learning and memory. Adult‐generated granule cells have been shown to play a role in spatial memory processes such as acquisition or retrieval, in particular during an immature stage when they exhibit a period of increased plasticity. Here, we demonstrate that immature and mature neurons born in the DG of adult rats are similarly activated in spatial memory processes. By imaging the activation of these two different neuron generations in the same rat and by using the immediate early gene Zif268, we show that these neurons are involved in both spatial memory acquisition and retrieval. These results demonstrate that adult‐generated granule cells are involved in memory beyond their immaturity stage. © 2015 Wiley Periodicals, Inc.
    Type of Medium: Online Resource
    ISSN: 1050-9631 , 1098-1063
    URL: Issue
    URL: Article
    DOI: 10.1002/hipo.v25.11
    DOI: 10.1002/hipo.22468
    Language: English
    Publisher: Wiley
    Publication Date: 2015
    detail.hit.zdb_id: 1498049-6
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  • 5
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    Running per se stimulates the dendritic arbor of newborn dentate granule cells in mouse hippocampus in a duration‐dependent manner
    Wiley ; 2016
    In:  Hippocampus Vol. 26, No. 3 ( 2016-03), p. 282-288
    Details
    In: Hippocampus, Wiley, Vol. 26, No. 3 ( 2016-03), p. 282-288
    Abstract: Laboratory rodents provided chronic unlimited access to running wheels display increased neurogenesis in the hippocampal dentate gyrus. In addition, recent studies indicate that such an access to wheels stimulates dendritic arborization in newly formed neurons. However, (i) the presence of the running wheel in the housing environment might also bear intrinsic influences on the number and shape of new neurons and (ii) the dendritic arborization of new neurons might be insensitive to moderate daily running activity (i.e., several hours). In keeping with these uncertainties, we have examined neurogenesis and dendritic arborization in newly formed granular cells in adult C57Bl/6N male mice housed for 3 weeks under standard conditions, with a locked wheel, with a running wheel set free 3 h/day, or with a running wheel set permanently free. The results indicate that the presence of a blocked wheel in the home cage increased cell proliferation, but not the number of new neurons while running increased in a duration‐dependent manner the number of newborn neurons, as assessed by DCX labeling. Morphological analyses of the dendritic tree of newborn neurons, as identified by BrdU‐DCX co‐staining, revealed that although the presence of the wheel stimulated their dendritic architecture, the amplitude of this effect was lower than that elicited by running activity, and was found to be running duration‐dependent. © 2015 Wiley Periodicals, Inc.
    Type of Medium: Online Resource
    ISSN: 1050-9631 , 1098-1063
    URL: Issue
    URL: Article
    DOI: 10.1002/hipo.v26.3
    DOI: 10.1002/hipo.22551
    Language: English
    Publisher: Wiley
    Publication Date: 2016
    detail.hit.zdb_id: 1498049-6
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  • 6
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    Online Resource
    Evaluation of simple and complex sensorimotor behaviours in rats with a partial lesion of the dopaminergic nigrostriatal system
    Wiley ; 2000
    In:  European Journal of Neuroscience Vol. 12, No. 1 ( 2000-01), p. 322-336
    Details
    In: European Journal of Neuroscience, Wiley, Vol. 12, No. 1 ( 2000-01), p. 322-336
    Abstract: We have examined the behavioural consequences of a partial unilateral dopaminergic denervation of the rat striatum. This partial lesion was obtained by an intrastriatal 6‐hydroxy‐dopamine injection (6‐OHDA, 20 or 10 μg divided between two injection sites) and was compared with a unilateral complete lesion resulting from an injection of 6‐OHDA (2 × 6 μg) into the medial forebrain bundle. Quantification of striatal dopamine (DA) and its metabolites, and the immunohistochemical evaluation of the nigrostriatal DA system confirmed the complete and partial lesions. Animals with complete striatal denervation displayed both apomorphine‐ and amphetamine‐induced rotations whereas the partial denervation elicited amphetamine‐induced rotations only. However, the rates of amphetamine‐induced rotation were not correlated with the size of the lesion. In contrast, the paw‐reaching impairments were significantly correlated with the striatal dopaminergic depletion. When evaluated in the staircase test, animals with partial denervation were impaired exclusively for the paw contralateral to the side of the lesion. This motor deficit (50–75%) included all components of the skilled paw use (i.e. attempt, motor coordination and success) and was observed at least 12 weeks after the lesion. However, these animals were able to perform normal stepping adjustments with the impaired paw, indicating that the partial lesion induced a coordination deficit of the paw rather than a deficit of movement initiation. After a complete lesion, stepping adjustments of the contralateral paw were dramatically impaired (by 80%), an akinesia which almost certainly accounted for the great deficit in skilled paw use. The paw‐reaching impairments resulting from the partial striatal denervation are proposed as a model of the early symptoms of Parkinson's disease and may be useful for the development of restorative therapies.
    Type of Medium: Online Resource
    ISSN: 0953-816X , 1460-9568
    URL: Article
    DOI: 10.1046/j.1460-9568.2000.00896.x
    Language: English
    Publisher: Wiley
    Publication Date: 2000
    detail.hit.zdb_id: 2005178-5
    SSG: 12
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