In:
Transfusion Medicine and Hemotherapy, S. Karger AG, Vol. 49, No. 2 ( 2022), p. 98-106
Abstract:
〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 Observational studies suggest that sex-mismatched transfusion is associated with increased mortality. Mechanisms driving mortality are not known but may include endothelial activation. The aim of this study is to investigate the effects of sex-mismatched red blood cell (RBC) transfusions on endothelial cell activation markers in critically ill patients. 〈 b 〉 〈 i 〉 Study Design and Methods: 〈 /i 〉 〈 /b 〉 In patients admitted to the intensive care unit who received a single RBC unit, blood samples were drawn before (T 〈 sub 〉 0 〈 /sub 〉 ), 1 h after (T 〈 sub 〉 1 〈 /sub 〉 ), and 24 h after transfusion (T 〈 sub 〉 24 〈 /sub 〉 ) for analysis of soluble syndecan-1, soluble intercellular adhesion molecule-1, soluble thrombomodulin (sTM), von Willebrand factor antigen, interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNFα). Changes in the levels of these factors were compared between sex-matched and sex-mismatched groups. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 Of 69 included patients, 32 patients were in the sex-matched and 37 patients were in the sex-mismatched group. Compared to baseline, sex-matched transfusion was associated with significant reduction in sTM level ( 〈 i 〉 p 〈 /i 〉 value = 0.03). Between-group comparison showed that levels of syndecan-1 and sTM were significantly higher in the sex-mismatched group compared to the sex-matched group at T 〈 sub 〉 24 〈 /sub 〉 ( 〈 i 〉 p 〈 /i 〉 value = 0.04 and 0.01, respectively). Also, TNFα and IL-6 levels showed a statistically marginal significant increase compared to baseline in the sex-mismatched group at T 〈 sub 〉 24 〈 /sub 〉 ( 〈 i 〉 p 〈 /i 〉 value = 0.06 and 0.05, respectively), but not in the sex-matched group. 〈 b 〉 〈 i 〉 Discussion: 〈 /i 〉 〈 /b 〉 Transfusion of a single sex-mismatched RBC unit was associated with higher syndecan-1 and sTM levels compared to transfusion of sex-matched RBC unit. These findings may suggest that sex-mismatched RBC transfusion is associated with endothelial activation.
Type of Medium:
Online Resource
ISSN:
1660-3796
,
1660-3818
Language:
English
Publisher:
S. Karger AG
Publication Date:
2022
detail.hit.zdb_id:
2100533-3
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