In:
npj Parkinson's Disease, Springer Science and Business Media LLC, Vol. 8, No. 1 ( 2022-11-12)
Abstract:
The relationship between APOE polymorphisms and Parkinson’s disease (PD) in black Africans has not been previously investigated. We evaluated the association between APOE polymorphic variability and self-declared cognition in 1100 Nigerians with PD and 1097 age-matched healthy controls. Cognition in PD was assessed using the single item cognition question (item 1.1) of the MDS-UPDRS. APOE genotype and allele frequencies did not differ between PD and controls ( p 〉 0.05). No allelic or genotypic association was observed between APOE and age at onset of PD. In PD, APOE ε 4/ ε 4 conferred a two-fold risk of cognitive impairment compared to one or no ε 4 (HR: 2.09 (95% CI: 1.13–3.89; p = 0.02)), while APOE ε 2 was associated with modest protection against cognitive impairment (HR: 0.41 (95% CI 0.19–0.99, p = 0.02)). Of 773 PD with motor phenotype and APOE characterized, tremor-dominant (TD) phenotype predominated significantly in ε2 carriers (87/135, 64.4%) compared to 22.2% in persons with postural instability/gait difficulty (PIGD) (30/135) and 13.3% in indeterminate (ID) (18/135, 13.3%) ( p = 0.037). Although the frequency of the TD phenotype was highest in homozygous ε 2 carriers (85.7%), the distribution of motor phenotypes across the six genotypes did not differ significantly ( p = 0.18). Altogether, our findings support previous studies in other ethnicities, implying a role for APOE ε 4 and ε 2 as risk and protective factors, respectively, for cognitive impairment in PD.
Type of Medium:
Online Resource
ISSN:
2373-8057
DOI:
10.1038/s41531-022-00411-x
Language:
English
Publisher:
Springer Science and Business Media LLC
Publication Date:
2022
detail.hit.zdb_id:
2819218-7
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