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  • 1
    Online Resource
    Online Resource
    Synthesis and characterization of chemically crosslinked gelatin and chitosan to produce hydrogels for biomedical applications
    Wiley ; 2021
    In:  Polymers for Advanced Technologies Vol. 32, No. 5 ( 2021-05), p. 2229-2239
    Details
    In: Polymers for Advanced Technologies, Wiley, Vol. 32, No. 5 ( 2021-05), p. 2229-2239
    Abstract: Gelatin and chitosan polysaccharides were chemically modified to get methacrylate functionality to obtain biocompatible hydrogels for use as tissue engineering scaffolds. The methacrylation reaction was verified by 1 H‐NMR. The degree of methacrylation was varied from 7% to 40% by changing the molar ratio of polysaccharide to methacrylic anhydride and the type of polysaccharide utilized. After the modification, polysaccharide‐based hydrogels were prepared by free‐radical polymerization in the presence of UV light and Irgacure 184 as a photoinitiator. The physical, chemical, and mechanical performances of the hydrogels were further characterized. Also, the biodegradability and the viability of the polysaccharide hydrogels were investigated using fibroblast cells. These cells were seeded directly onto the hydrogel surface, populated the entirety of the hydrogel, and remained viable for up to 1 week. Altogether, the modified polysaccharides exhibit the properties which make them crucial for applications in the field of regenerative medicine.
    Type of Medium: Online Resource
    ISSN: 1042-7147 , 1099-1581
    URL: Issue
    URL: Article
    DOI: 10.1002/pat.v32.5
    DOI: 10.1002/pat.5257
    RVK:
    VA 6586
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 1481102-9
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  • 2
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    Online Resource
    Occurrence, Antimicrobial Resistance Pattern and Plasmid Profile of Salmonella spp. Isolated from Raw Beef Meat in Dhaka City
    Bangladesh Academy of Sciences ; 2016
    In:  Bangladesh Journal of Microbiology Vol. 29, No. 1 ( 2016-06-25), p. 17-22
    Details
    In: Bangladesh Journal of Microbiology, Bangladesh Academy of Sciences, Vol. 29, No. 1 ( 2016-06-25), p. 17-22
    Abstract: Salmonella is motile enterobacterium that causes diseases like typhoid fever, paratyphoid fever and food borne illnesses. Salmonella infections are due to the consumption of contaminated foods. The objective of the present study was to observe the sanitary and hygienic conditions of the retail areas and to isolate pathogenic Salmonella spp from raw beef, to observe antimicrobial sensitivity pattern of Salmonella spp from the raw beef. A total of forty (40) raw beef samples were collected from the sixteen different butcher shops of the four different markets namely Bazaar-1, Bazaar-2, Bazaar-3 and Bazaar-4 of Dhaka City to determine the presence of the significant enteric pathogen Salmonella. From the colony characteristic and biochemical properties, it was found that out of forty samples Salmonella were found in thirty four (85%) samples. The prevalence of drug resistance bacteria were also assayed by antibiotic susceptibility testing. Among thirty four isolates, nearly 6% (2), 32% (11), 76% (26), 6%(2) and 32% (12) isolates showed resistance to Nitrofurantoin, Nalidixic acid, Ampicillin , Gentamycin and Trimethoprim-sulfamethoxazole respectively. Almost 85%(29), 62%(21), 24% (8), 91% (31), 91% (31)and 68% (23) isolates showed sensitivity to Nitrofurantoin, Nalidixic acid, Ampicillin,Ciprofloxacin,Gentamycin and Trimethoprim-sulfamethoxazole respectively Some isolates also showed intermediate in sensitivity reaction for example 3% (1), 6% (2), 3% (1) and 9% (3) isolates showed intermediate in sensitivity reaction to Nitrofurantoin, Ampicillin, Ciprofloxacin, Gentamycin and Nitrofurantoin respectively. Twenty four isolates were investigated for the plasmid profile analysis where thirteen isolates (about 54%) were found to carry plasmids of different sizes ranging from small (2.3 kb) to large sizes ( 〉 10kb and also greater than the chromosomal DNA). The presence of large plasmids may be a possible source of drug resistance. The results of this study demonstrate the unhygienic quality of beef meat and their risk of contracting food borne infections to the consumers.Bangladesh J Microbiol, Volume 29, Number 1, June 2012, pp 17-22
    Type of Medium: Online Resource
    ISSN: 2408-8374 , 1011-9981
    URL: Article
    DOI: 10.3329/bjm.v29i1.28429
    Language: Unknown
    Publisher: Bangladesh Academy of Sciences
    Publication Date: 2016
    detail.hit.zdb_id: 2549245-7
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  • 3
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    Online Resource
    Microbial Contamination of Water in Around Dhaka City
    Bangladesh Academy of Sciences ; 1970
    In:  Bangladesh Journal of Scientific and Industrial Research Vol. 43, No. 2 ( 1970-01-01), p. 273-276
    Details
    In: Bangladesh Journal of Scientific and Industrial Research, Bangladesh Academy of Sciences, Vol. 43, No. 2 ( 1970-01-01), p. 273-276
    Abstract: A total of 109 water samples were collected from around Dhaka city and examined for microbial contamination. Samples were collected in sterilized screw capped glass bottles, transported to the laboratory in cold and processed within 6 hours of their collection. All river water, pond water and household water were found heavily contaminated with coliform, faecal coliform, E. Coli and Salmonella whereas tube well water and bottled water was devoid of faecal coliform, E. Coli and Salmonella. A significant correlation between total number of total coliform and percentage of Salmonella was also investigated. It is suggested that water must be boiled before use. Key Words: Water contamination, Total coliform, Faecal coliform, Salmonella DOI: 10.3329/bjsir.v43i2.972 Bangladesh J. Sci. Ind. Res. 43(2), 273-276, 2008 
    Type of Medium: Online Resource
    ISSN: 2224-7157 , 0304-9809
    URL: Article
    DOI: 10.3329/bjsir.v43i2.972
    Language: Unknown
    Publisher: Bangladesh Academy of Sciences
    Publication Date: 1970
    detail.hit.zdb_id: 2381023-3
    SSG: 11
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  • 4
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    Online Resource
    Synthesis and characterization of photopolymerizable hydrogels based on poly (ethylene glycol) for biomedical applications
    Wiley ; 2021
    In:  Journal of Applied Polymer Science Vol. 138, No. 21 ( 2021-06-05)
    Details
    In: Journal of Applied Polymer Science, Wiley, Vol. 138, No. 21 ( 2021-06-05)
    Abstract: Hydrogels are polymeric materials widely used in medicine due to their similarity with the biological components of the body. Hydrogels are biocompatible materials that have the potential to promote cell proliferation and tissue support because of their hydrophilic nature, porous structure, and elastic mechanical properties. In this work, we demonstrate the microwave‐assisted synthesis of three molecular weight varieties of poly(ethylene glycol) dimethacrylate (PEGDMA) with different mechanical and thermal properties and the rapid photo of them using 1‐hydroxy‐cyclohexyl‐phenyl‐ketone (Irgacure 184) as UV photoinitiator. The effects of the poly(ethylene glycol) molecular weight and degree of acrylation on swelling, mechanical, and rheological properties of hydrogels were investigated. The biodegradability of the PEGDMA hydrogels, as well as the ability to grow and proliferate cells, was examined for its viability as a scaffold in tissue engineering. Altogether, the biomaterial hydrogel properties open the way for applications in the field of regenerative medicine for functional scaffolds and tissues.
    Type of Medium: Online Resource
    ISSN: 0021-8995 , 1097-4628
    URL: Issue
    URL: Article
    DOI: 10.1002/app.v138.21
    DOI: 10.1002/app.50489
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 1491105-X
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  • 5
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    Online Resource
    Kaiso (ZBTB33) subcellular partitioning functionally links LC3A/B, the tumor microenvironment, and breast cancer survival
    Springer Science and Business Media LLC ; 2021
    In:  Communications Biology Vol. 4, No. 1 ( 2021-02-01)
    Details
    In: Communications Biology, Springer Science and Business Media LLC, Vol. 4, No. 1 ( 2021-02-01)
    Abstract: The use of digital pathology for the histomorphologic profiling of pathological specimens is expanding the precision and specificity of quantitative tissue analysis at an unprecedented scale; thus, enabling the discovery of new and functionally relevant histological features of both predictive and prognostic significance. In this study, we apply quantitative automated image processing and computational methods to profile the subcellular distribution of the multi-functional transcriptional regulator, Kaiso ( ZBTB33 ), in the tumors of a large racially diverse breast cancer cohort from a designated health disparities region in the United States. Multiplex multivariate analysis of the association of Kaiso’s subcellular distribution with other breast cancer biomarkers reveals novel functional and predictive linkages between Kaiso and the autophagy-related proteins, LC3A/B, that are associated with features of the tumor immune microenvironment, survival, and race. These findings identify effective modalities of Kaiso biomarker assessment and uncover unanticipated insights into Kaiso’s role in breast cancer progression.
    Type of Medium: Online Resource
    ISSN: 2399-3642
    URL: Article
    DOI: 10.1038/s42003-021-01651-y
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2021
    detail.hit.zdb_id: 2919698-X
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  • 6
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    Assessment and Treatment of the Supplied Pipeline Water of Selected Areas of Dhaka City
    Bangladesh Academy of Sciences ; 1970
    In:  Bangladesh Journal of Scientific and Industrial Research Vol. 44, No. 3 ( 1970-01-01), p. 335-340
    Details
    In: Bangladesh Journal of Scientific and Industrial Research, Bangladesh Academy of Sciences, Vol. 44, No. 3 ( 1970-01-01), p. 335-340
    Abstract: An investigation was carried out to assess the microbiological and physico-chemical characteristics of piped water supply of different areas of Dhaka City and the results were compared with the standard value of different organizations (i.e., WHO, DoE). The results revealed that microbiologically, 88.9% samples failed to ensure the standard level for drinking water due to the presence of TVB (total viable bacteria), TC (total coliform), TFC (total faecal coliform), TF (total fungal), Salmonella sp. and klebsiella sp. in the supplied water. However except turbidity other physico-chemical factors of supplied water were found satisfactory. Boiling for 5 minutes was found suitable for treatment of contaminated supplied water sample. Bleaching powder, sodium hypochlorite solution and Halotab were found suitable for the treatment of contaminated supplied water samples. Key words: Water, Assessment, Microbiological, Physico-chemical parameters, Disinfectant. DOI: 10.3329/bjsir.v44i3.4407 Bangladesh J. Sci. Ind. Res. 44(3),335-340, 2009
    Type of Medium: Online Resource
    ISSN: 2224-7157 , 0304-9809
    URL: Article
    DOI: 10.3329/bjsir.v44i3.4407
    Language: Unknown
    Publisher: Bangladesh Academy of Sciences
    Publication Date: 1970
    detail.hit.zdb_id: 2381023-3
    SSG: 11
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  • 7
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    Online Resource
    Microbiological Quality of Local Market Vended Freshly Squeezed Fruit Juices in Dhaka City, Bangladesh
    Bangladesh Academy of Sciences ; 1970
    In:  Bangladesh Journal of Scientific and Industrial Research Vol. 44, No. 4 ( 1970-01-01), p. 421-424
    Details
    In: Bangladesh Journal of Scientific and Industrial Research, Bangladesh Academy of Sciences, Vol. 44, No. 4 ( 1970-01-01), p. 421-424
    Abstract: Freshly squeezed or freshly prepared fruit juices sold by local market vendors in Dhaka city were analyzed for the microbiological quality. Total viable bacterial counts, fungal counts, total coliform, faecal coliform and the presence of pathogenic microorganisms such as E. coli, Bacillus cereus, Staphylococcus aureus, Salmonella, Streptococcus were analyzed by standard methods. The total viable count of samples ranged from 3.00×102 to 9.60×108 and fungal counts ranged from 1.00×102 to 8.05×104. Out of 114 freshly prepared fruit juices samples collected 113 samples (99%) showed the presence of coliform and E. coli. The other bacteria like B. cereus, Staphylococcus aureus, Salmonella, Streptococcus were found in 64.91%, 6.14%, 7.89% and (5.26%) of the tested samples. The number and type of microorganisms recovered from the freshly squeezed fruit juices made them unsafe for drinking. It was concluded that due to unhygienic fruit handling in the unsanitary environmental conditions under which the vendors operate the juices become contaminated with harmful bacteria. The results of this study demonstrate the unhygienic quality of popular types of market vended freshly squeezed fruit juices and their risk to the consumers. Key Words: Fruit juices; Microorganisms; Contamination; E. coli; Microbiological quality standards.   DOI: 10.3329/bjsir.v44i4.4591 Bangladesh J. Sci. Ind. Res. 44(4), 421-424, 2009
    Type of Medium: Online Resource
    ISSN: 2224-7157 , 0304-9809
    URL: Article
    DOI: 10.3329/bjsir.v44i4.4591
    Language: Unknown
    Publisher: Bangladesh Academy of Sciences
    Publication Date: 1970
    detail.hit.zdb_id: 2381023-3
    SSG: 11
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  • 8
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    Online Resource
    A Novel CD206 Targeting Peptide Inhibits Bleomycin-Induced Pulmonary Fibrosis in Mice
    MDPI AG ; 2023
    In:  Cells Vol. 12, No. 9 ( 2023-04-26), p. 1254-
    Details
    In: Cells, MDPI AG, Vol. 12, No. 9 ( 2023-04-26), p. 1254-
    Abstract: Activated M2-polarized macrophages are drivers of pulmonary fibrosis in several clinical scenarios, including Idiopathic Pulmonary Fibrosis (IPF). In this study, we investigated the effects of targeting the CD206 receptor in M2-like macrophages with a novel synthetic analogue of a naturally occurring Host Defense Peptide (HDP), RP-832c, to decrease profibrotic cytokines. RP-832c selectively binds to CD206 on M2-polarized bone marrow-derived macrophages (BMDM) in vitro, resulting in a time-dependent decrease in CD206 expression and a transient increase in M1-macrophage marker TNF-α. To elucidate the antifibrotic effects of RP-832c, we used a murine model of bleomycin (BLM)-induced early-stage pulmonary fibrosis. RP-832c significantly reduced fibrosis in a dose-dependent manner, and decreased CD206, TGF-β1, and α-SMA expression in mouse lungs. Similarly, in an established model of lung fibrosis, RP-832c significantly decreased lung fibrosis and significantly decreased inflammatory cytokines TNF-α, IL-6, IL-10, IFN-γ, CXCL1/2, and fibrosis markers TGF-β1 and MMP-13. In comparison with the FDA-approved drugs Nintedanib and Pirfenidone, RP-832c exhibited a similar reduction in fibrosis compared to Pirfenidone, and to a greater extent than Nintedanib, with no apparent toxicities observed. In summary, our findings showed that inhibiting the profibrotic alternatively activated M2-like macrophages using a novel peptide, RP-832c, could reduce BLM-induced pulmonary fibrosis in mice, warranting the therapeutic potential of this peptide for patients with pulmonary fibrosis.
    Type of Medium: Online Resource
    ISSN: 2073-4409
    URL: Article
    DOI: 10.3390/cells12091254
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2661518-6
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  • 9
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    Immune Profile of Exosomes in African American Breast Cancer Patients Is Mediated by Kaiso/THBS1/CD47 Signaling
    MDPI AG ; 2023
    In:  Cancers Vol. 15, No. 8 ( 2023-04-13), p. 2282-
    Details
    In: Cancers, MDPI AG, Vol. 15, No. 8 ( 2023-04-13), p. 2282-
    Abstract: African American (AA) women with breast cancer are more likely to have higher inflammation and a stronger overall immune response, which correlate with poorer outcomes. In this report, we applied the nanostring immune panel to identify differences in inflammatory and immune gene expression by race. We observed a higher expression of multiple cytokines in AA patients compared to EA patients, with high expression of CD47, TGFB1, and NFKB1 associated with the transcriptional repressor Kaiso. To investigate the mechanism associated with this expression pattern, we observed that Kaiso depletion results in decreased expression of CD47, and its ligand SIRPA. Furthermore, Kaiso appears to directly bind to the methylated sequences of the THBS1 promotor and repress gene expression. Similarly, Kaiso depletion attenuated tumor formation in athymic nude mice, and these Kaiso-depleted xenograft tissues showed significantly higher phagocytosis and increased infiltration of M1 macrophages. In vitro validation using MCF7 and THP1 macrophages treated with Kaiso-depleted exosomes showed a reduced expression of immune-related markers (CD47 and SIRPA) and macrophage polarization towards the M1 phenotype compared to MCF7 cells treated with exosomes isolated from high-Kaiso cells. Lastly, analysis of TCGA breast cancer patient data demonstrates that this gene signature is most prominent in the basal-like subtype, which is more frequently observed in AA breast cancer patients.
    Type of Medium: Online Resource
    ISSN: 2072-6694
    URL: Article
    DOI: 10.3390/cancers15082282
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2527080-1
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  • 10
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    Abstract B062: Kaiso influences immune signaling of breast cancer exosomes
    American Association for Cancer Research (AACR) ; 2020
    In:  Cancer Epidemiology, Biomarkers & Prevention Vol. 29, No. 6_Supplement_2 ( 2020-06-01), p. B062-B062
    Details
    In: Cancer Epidemiology, Biomarkers & Prevention, American Association for Cancer Research (AACR), Vol. 29, No. 6_Supplement_2 ( 2020-06-01), p. B062-B062
    Abstract: Introduction: Exosomes are communication vesicles act as mediator of intracellular transfer of genetic information, act an important role in intercommunication between tumor cells and immune cells. However, the mechanism underlining this cell-cell communication is not well understanding, particularly in African American breast cancer patients. Recently, our lab has demonstrated that Kaiso, a novel bi-modal transcription factor is highly expressed in African American breast cancer and notably, high Kaiso expression correlates with breast cancer aggressiveness and the disparity in survival outcomes of breast cancer patients of African American compared to European American patients. However, the differential expression and biological consequences of Kaiso in immune signaling of breast cancer exosomes has not been studied yet. Herein we demonstrate the biological role of Kaiso in immune signaling in breast cancer exosomes. Methods: In this study we utilized Nanostring immune profiling technology along with multiple in vitro and in vivo assays were used to study the role of Kaiso in breast cancer immune escape. Results: Nanostring pan cancer immune profiling demonstrated that European American breast cancer exosomes exhibited higher expression of TILs markers, T cell activation markers and CD8+T Cells markers compared to African American, while we observed an increase in the expression of the anti-phagocytic molecule CD47 in breast cancer patient exosomes of African American compared to European American patients. In addition to that CD47 and SIRP-α (Signal Regulatory Protein) are highly expressed in Kaiso-scrambled MDA-MB-231 cells (sh-Scr) and exosomes, whereas THBS1, which is a regulator of CD47 expression and is regarded as angiogenesis inhibitor is significantly increased in sh-Kaiso MDA-231 cells and exosomes. Additionally, we observed that Kaiso directly binds methylated sequences in the promoter region of CD47 and THBS1 by ChIP assay. Furthermore, in vivo sh-Kaiso cells injected into athymic mice exhibited delayed tumor formation after four weeks with smaller tumor size as compared to sh-SCR cells, and we observed higher expression of THBS1 with lower expression of CD47 and SIRP-α molecules by IHC and exosomes isolated from invivo tumors, indicating that Kaiso is associated with macrophage mediated immune escape. Conclusion: These findings demonstrate the important role of kaiso in immune signaling through exosomes which may be related with more aggressive cancer phenotype in breast cancer specially in African Americans. Citation Format: Shakir U Ahmed, Brittany Davis, Benjamin Adu Addai, Balasubramanyanam Karanam, Melissa Davis, William Grizzle, Honghe Wang, Clayton C Yates. Kaiso influences immune signaling of breast cancer exosomes [abstract]. In: Proceedings of the Twelfth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2019 Sep 20-23; San Francisco, CA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2020;29(6 Suppl_2):Abstract nr B062.
    Type of Medium: Online Resource
    ISSN: 1055-9965 , 1538-7755
    URL: Article
    DOI: 10.1158/1538-7755.DISP19-B062
    Language: English
    Publisher: American Association for Cancer Research (AACR)
    Publication Date: 2020
    detail.hit.zdb_id: 2036781-8
    detail.hit.zdb_id: 1153420-5
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