In:
Clinical Transplantation, Wiley, Vol. 22, No. s19 ( 2008-07), p. 50-52
Abstract:
Abstract: A 38‐yr‐old man with chronic renal failure received a second kidney transplantation from a cadaveric donor. Complement‐dependent cytotoxicity cross‐match (CDC) was negative against T cells, but positive with the B‐cell warm test. Human leukocyte antigen (HLA)‐typing showed a one haplo‐identical match. The blood type was compatible. He was treated with tacrolimus, mycophenolate mofetil (MMF), methylpredonisolone (MP), and basiliximab as immunosuppressive therapy. A clinical episode graft biopsy and Flow‐PRA on post‐operative day (POD) 19 showed anti‐HLA antibody‐mediated acute rejection (AHR). The patient was treated with plasmapheresis (PP). Renal biopsy performed on POD 65 because of re‐rise of serum creatinine level showed worsening of renal injury. The patient was treated with rituximab (100 mg/body) with PP and MP pulse therapy, followed by tacrolimus and MMF. Graft function thereafter improved. A renal allograft biopsy specimen on POD 300 and Flow‐PRA showed the remission of AHR within one‐yr after transplantation.
Type of Medium:
Online Resource
ISSN:
0902-0063
,
1399-0012
DOI:
10.1111/ctr.2008.22.issue-s19
DOI:
10.1111/j.1399-0012.2008.00849.x
Language:
English
Publisher:
Wiley
Publication Date:
2008
detail.hit.zdb_id:
2739458-X
detail.hit.zdb_id:
2004801-4
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