In:
International Journal of Cancer, Wiley, Vol. 145, No. 11 ( 2019-12), p. 3052-3063
Abstract:
What's new? Disruptions in the expression of microRNAs contribute to the onset and progression of osteosarcoma. Here, the authors looked at miRNA‐16, which is downregulated in osteosarcoma. One strand of the miRNA is the guide strand, while the other, “passenger” strand, is preferentially degraded. miR‐16 originates from two different loci, and though both loci produce the same guide strand, they produce different passenger strands, miR‐16‐1‐3p and miR‐16‐2‐3p. All three microRNAs, the authors found, act as tumor suppressors and reduce metastasis in osteosarcoma. Boosting their expression sensitizes the cells to chemotherapy. The authors also identified FGFR2 as a target of miR‐16‐1‐3p and miR‐16‐2‐3p.
Type of Medium:
Online Resource
ISSN:
0020-7136
,
1097-0215
Language:
English
Publisher:
Wiley
Publication Date:
2019
detail.hit.zdb_id:
218257-9
detail.hit.zdb_id:
1474822-8
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