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Colombian surgical outcomes study insights on perioperative mortality rate, a main indicator of the lancet commission on global surgery – a prospective cohort study

Pérez Rivera, Carlos J. ; Lozano-Suárez, Nicolás ; Velandia-Sánchez, Alejandro ; [et al.]

Elsevier BV ; 2024

In: The Lancet Regional Health - Americas Vol. 38 ( 2024-10), p. 100862-

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In: The Lancet Regional Health - Americas, Elsevier BV, Vol. 38 ( 2024-10), p. 100862-

Type of Medium: Online Resource

ISSN: 2667-193X

URL: Article

DOI: 10.1016/j.lana.2024.100862

Language: English

Publisher: Elsevier BV

Publication Date: 2024

detail.hit.zdb_id: 3096925-6

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Effects of different periods of paradoxical sleep deprivation and sleep recovery on lipid and glucose metabolism and appetite hormones in rats

Brianza-Padilla, Malinalli ; Bonilla-Jaime, Herlinda ; Almanza-Pérez, Julio César ; [et al.]

Canadian Science Publishing ; 2016

In: Applied Physiology, Nutrition, and Metabolism Vol. 41, No. 3 ( 2016-03), p. 235-243

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In: Applied Physiology, Nutrition, and Metabolism, Canadian Science Publishing, Vol. 41, No. 3 ( 2016-03), p. 235-243

Abstract: Sleep has a fundamental role in the regulation of energy balance, and it is an essential and natural process whose precise impacts on health and disease have not yet been fully elucidated. The aim of this study was to assess the consequences of different periods of paradoxical sleep deprivation (PSD) and recovery from PSD on lipid profile, oral glucose tolerance test (OGTT) results, and changes in insulin, corticosterone, ghrelin, and leptin concentrations. Three-month-old male Wistar rats weighing 250–350 g were submitted to 24, 96, or 192 h of PSD or 192 h of PSD with 480 h of recovery. The PSD was induced by the multiple platforms method. Subsequently, the animals were submitted to an OGTT. One day later, the animals were killed and the levels of triglycerides, total cholesterol, lipoproteins (low-density lipoprotein, very-low-density lipoprotein, and high-density lipoprotein), insulin, ghrelin, leptin, and corticosterone in plasma were quantified. There was a progressive decrease in body weight with increasing duration of PSD. The PSD induced basal hypoglycemia over all time periods evaluated. Evaluation of areas under the curve revealed progressive hypoglycemia only after 96 and 192 h of PSD. There was an increase in corticosterone levels after 192 h of PSD. We conclude that PSD induces alterations in metabolism that are reversed after a recovery period of 20 days.

Type of Medium: Online Resource

ISSN: 1715-5312 , 1715-5320

URL: Article

DOI: 10.1139/apnm-2015-0337

Language: English

Publisher: Canadian Science Publishing

Publication Date: 2016

SSG: 31

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Selected MicroRNAs Define Cell Fate Determination of Murine Central Memory CD8 T Cells

Almanza, Gonzalo ; Fernandez, Antonio ; Volinia, Stefano ; [et al.]

Public Library of Science (PLoS) ; 2010

In: PLoS ONE Vol. 5, No. 6 ( 2010-6-22), p. e11243-

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In: PLoS ONE, Public Library of Science (PLoS), Vol. 5, No. 6 ( 2010-6-22), p. e11243-

Type of Medium: Online Resource

ISSN: 1932-6203

URL: Article

DOI: 10.1371/journal.pone.0011243

DOI: 10.1371/journal.pone.0011243.g001

DOI: 10.1371/journal.pone.0011243.g002

DOI: 10.1371/journal.pone.0011243.g003

DOI: 10.1371/journal.pone.0011243.g004

DOI: 10.1371/journal.pone.0011243.g005

DOI: 10.1371/journal.pone.0011243.s001

DOI: 10.1371/journal.pone.0011243.s002

DOI: 10.1371/journal.pone.0011243.s003

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2010

detail.hit.zdb_id: 2267670-3

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Endoplasmic reticulum stress drives a regulatory phenotype in human T-cell clones

Franco, Alessandra ; Almanza, Gonzalo ; Burns, Jane C. ; [et al.]

Elsevier BV ; 2010

In: Cellular Immunology Vol. 266, No. 1 ( 2010), p. 1-6

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In: Cellular Immunology, Elsevier BV, Vol. 266, No. 1 ( 2010), p. 1-6

Type of Medium: Online Resource

ISSN: 0008-8749

URL: Article

DOI: 10.1016/j.cellimm.2010.09.006

RVK:

XA 10000

Language: English

Publisher: Elsevier BV

Publication Date: 2010

detail.hit.zdb_id: 1462601-9

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Synthesis and delivery of short, noncoding RNA by B lymphocytes

Almanza, Gonzalo ; Anufreichik, Veronika ; Rodvold, Jeffrey J. ; [et al.]

Proceedings of the National Academy of Sciences ; 2013

In: Proceedings of the National Academy of Sciences Vol. 110, No. 50 ( 2013-12-10), p. 20182-20187

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In: Proceedings of the National Academy of Sciences, Proceedings of the National Academy of Sciences, Vol. 110, No. 50 ( 2013-12-10), p. 20182-20187

Abstract: Evolutionarily conserved short (20–30 nucleotides) noncoding RNAs (microRNAs) are powerful regulators of gene expression in a variety of physiological and pathological processes. As such, means to efficiently modulate microRNA function constitute an important therapeutic opportunity. Here we demonstrate that primary B lymphocytes can be genetically programmed with nonviral plasmid DNA for the biogenesis and delivery of antisense sequences (anti-microRNA) against microRNA-150 (miR-150). Within 18 h of transfection with an anti-miR-150 construct, primary B lymphocytes secrete ∼3,000 copies of anti-miR-150 molecules per cell. Anti-miR-150 molecules released by B lymphocytes were internalized by CD8 T lymphocytes during cross-priming in vitro and in vivo, resulting in marked down-regulation of endogenous miR-150. However, such internalization was not observed in the absence of cross-priming. These results suggest that shuttling anti-miR-150 molecules from B lymphocytes to T cells requires the activation of receiver T cells via the antigen receptor. Finally, anti-miR-150 synthesized in B cells were secreted both as free and extracellular vesicle-associated fractions, but only extracellular vesicle-associated anti-miR-150 were apparently taken up by CD8 T cells. Collectively, these data indicate that primary B lymphocytes represent an efficient platform for the synthesis and delivery of short, noncoding RNA, paving the way for an approach to immunogenomic therapies.

Type of Medium: Online Resource

ISSN: 0027-8424 , 1091-6490

URL: Article

DOI: 10.1073/pnas.1311145110

RVK:

TA 1000

RVK:

WA 15000

Language: English

Publisher: Proceedings of the National Academy of Sciences

Publication Date: 2013

detail.hit.zdb_id: 209104-5

detail.hit.zdb_id: 1461794-8

SSG: 11

SSG: 12

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ER stress drives Lipocalin 2 upregulation in prostate cancer cells in an NF-κB-dependent manner

Mahadevan, Navin R ; Rodvold, Jeffrey ; Almanza, Gonzalo ; [et al.]

Springer Science and Business Media LLC ; 2011

In: BMC Cancer Vol. 11, No. 1 ( 2011-12)

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In: BMC Cancer, Springer Science and Business Media LLC, Vol. 11, No. 1 ( 2011-12)

Abstract: Tumor cells adapt to endoplasmic reticulum (ER) stress through a set of conserved intracellular pathways, as part of a process termed the unfolded protein response (UPR). The expression of UPR genes/proteins correlates with increasing progression and poor clinical outcome of several tumor types, including prostate cancer. UPR signaling can activate NF-κB, a master regulator of transcription of pro-inflammatory, tumorigenic cytokines. Previous studies have shown that Lipocalin 2 (Lcn2) is upregulated in several epithelial cancers, including prostate cancer, and recently Lcn2 was implicated as a key mediator of breast cancer progression. Here, we hypothesize that the tumor cell UPR regulates Lcn2 production. Methods We interrogated Lcn2 regulation in murine and human prostate cancer cells undergoing pharmacological and physiological ER stress, and tested UPR and NF-κB dependence by using pharmacological inhibitors of these signaling pathways. Results Induction of ER stress using thapsigargin (Tg), a canonical pharmacologic ER stress inducer, or via glucose deprivation, a physiologic ER stressor present in the tumor microenvironment, upregulates LCN2 production in murine and human prostate cancer cells. Inhibition of the UPR using 4-phenylbutyric acid (PBA) dramatically decreases Lcn2 transcription and translation. Inhibition of NF-κB in prostate cancer cells undergoing Tg-mediated ER stress by BAY 11-7082 abrogates Lcn2 upregulation. Conclusions We conclude that the UPR activates Lcn2 production in prostate cancer cells in an NF-κB-dependent manner. Our results imply that the observed upregulation of Lipocalin 2 in various types of cancer cells may be the direct consequence of concomitant UPR activation, and that the ER stress/Lipocalin 2 axis is a potential new target for intervention in cancer progression.

Type of Medium: Online Resource

ISSN: 1471-2407

URL: Article

DOI: 10.1186/1471-2407-11-229

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2011

detail.hit.zdb_id: 2041352-X

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Aprendizaje acelerado y desarrollador: alternativa para perfeccionar la expresión oral de la lengua inglesa

Almanza Casola, Gonzalo Rafael

Editorial de la Universidad de Granada ; 2008

In: Porta Linguarum Revista Interuniversitaria de Didáctica de las Lenguas Extranjeras

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In: Porta Linguarum Revista Interuniversitaria de Didáctica de las Lenguas Extranjeras, Editorial de la Universidad de Granada

Type of Medium: Online Resource

ISSN: 1697-7467

URL: Article

DOI: 10.30827/Digibug.31780

Language: Unknown

Publisher: Editorial de la Universidad de Granada

Publication Date: 2008

detail.hit.zdb_id: 2423901-X

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IRE1α regulates macrophage polarization, PD-L1 expression, and tumor survival

Batista, Alyssa ; Rodvold, Jeffrey J. ; Xian, Su ; [et al.]

Public Library of Science (PLoS) ; 2020

In: PLOS Biology Vol. 18, No. 6 ( 2020-6-10), p. e3000687-

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In: PLOS Biology, Public Library of Science (PLoS), Vol. 18, No. 6 ( 2020-6-10), p. e3000687-

Type of Medium: Online Resource

ISSN: 1545-7885

URL: Article

DOI: 10.1371/journal.pbio.3000687

DOI: 10.1371/journal.pbio.3000687.g001

DOI: 10.1371/journal.pbio.3000687.g002

DOI: 10.1371/journal.pbio.3000687.g003

DOI: 10.1371/journal.pbio.3000687.g004

DOI: 10.1371/journal.pbio.3000687.g005

DOI: 10.1371/journal.pbio.3000687.g006

DOI: 10.1371/journal.pbio.3000687.t001

DOI: 10.1371/journal.pbio.3000687.s001

DOI: 10.1371/journal.pbio.3000687.s002

DOI: 10.1371/journal.pbio.3000687.s003

DOI: 10.1371/journal.pbio.3000687.s004

DOI: 10.1371/journal.pbio.3000687.s005

DOI: 10.1371/journal.pbio.3000687.s006

DOI: 10.1371/journal.pbio.3000687.s007

DOI: 10.1371/journal.pbio.3000687.s008

DOI: 10.1371/journal.pbio.3000687.s009

DOI: 10.1371/journal.pbio.3000687.s010

DOI: 10.1371/journal.pbio.3000687.s011

DOI: 10.1371/journal.pbio.3000687.s012

DOI: 10.1371/journal.pbio.3000687.s013

DOI: 10.1371/journal.pbio.3000687.r001

DOI: 10.1371/journal.pbio.3000687.r002

DOI: 10.1371/journal.pbio.3000687.r003

DOI: 10.1371/journal.pbio.3000687.r004

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2020

detail.hit.zdb_id: 2126773-X

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KDEL-Retained Antigen in B Lymphocytes Induces a Proinflammatory Response: A Possible Role for Endoplasmic Reticulum Stress in Adaptive T Cell Immunity

Wheeler, Matthew C. ; Rizzi, Marta ; Sasik, Roman ; [et al.]

The American Association of Immunologists ; 2008

In: The Journal of Immunology Vol. 181, No. 1 ( 2008-07-01), p. 256-264

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In: The Journal of Immunology, The American Association of Immunologists, Vol. 181, No. 1 ( 2008-07-01), p. 256-264

Abstract: Generally, APCs activate CD4 T cells against peptides derived from exogenous Ag in the context of MHC II molecules. In this study, using transgenic B lymphocytes as model APCs, we demonstrate CD4 T cell priming in vivo against peptides derived from endogenously synthesized Ag targeted either to the cytosol or to the endoplasmic reticulum (ER). Surprisingly, priming by Ag containing the KDEL-retention motif yielded higher levels of two important proinflammatory cytokines, IFN-γ and TNF-α, in responding CD4 T cells. Importantly, we found that KDEL-mediated retention of Ag up-regulates ER-stress responsive genes in primary B lymphocytes. We also found that thapsigargin treatment of A20 lymphoma cells up-regulates transcription of ER stress and proinflammatory genes along with IL-23p19. Induction of ER stress by thapsigargin also up-regulated IL-23p19 in primary B lymphocytes, macrophages, and bone marrow-derived dendritic cells. We conclude that perturbation of the secretory pathway and/or ER stress play an important role in modulating the gene program in professional APCs and in shaping CD4 T cell responses in vivo. These findings are relevant to a better understanding of the immune response after infection by viral and bacterial pathogens and the pathogenesis of certain autoimmune diseases.

Type of Medium: Online Resource

ISSN: 0022-1767 , 1550-6606

URL: Article

DOI: 10.4049/jimmunol.181.1.256

RVK:

XA 54100

RVK:

XA 10000

Language: English

Publisher: The American Association of Immunologists

Publication Date: 2008

detail.hit.zdb_id: 1475085-5

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Enhanced recovery after low- and medium-risk liver transplantation. A single-center prospective observational cohort study

Rodríguez-Laiz, Gonzalo P. ; Melgar, Paola ; Alcázar-López, Cándido ; [et al.]

Ovid Technologies (Wolters Kluwer Health) ; 2021

In: International Journal of Surgery Vol. 85 ( 2021-01), p. 46-54

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In: International Journal of Surgery, Ovid Technologies (Wolters Kluwer Health), Vol. 85 ( 2021-01), p. 46-54

Type of Medium: Online Resource

ISSN: 1743-9191

URL: Article

DOI: 10.1016/j.ijsu.2020.12.003

Language: English

Publisher: Ovid Technologies (Wolters Kluwer Health)

Publication Date: 2021

detail.hit.zdb_id: 2201966-2

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