In:
Clinical & Translational Immunology, Wiley, Vol. 8, No. 11 ( 2019-01)
Kurzfassung:
Effects of Zika virus (ZIKV) infection on placental development during pregnancy are unclear. Methods Full‐term placentas from three women, each infected with ZIKV during specific pregnancy trimesters, were harvested for anatomic, immunologic and transcriptomic analysis. Results In this study, each woman exhibited a unique immune response with raised IL ‐1 RA , IP ‐10, EGF and RANTES expression and neutrophil numbers during the acute infection phase. Although ZIKV NS 3 antigens co‐localised to placental Hofbauer cells, the placentas showed no anatomic defects. Transcriptomic analysis of samples from the placentas revealed that infection during trimester 1 caused a disparate cellular response centred on differential eIF 2 signalling, mitochondrial dysfunction and oxidative phosphorylation. Despite these, the babies were delivered without any congenital anomalies. Conclusion These findings should translate to improve clinical prenatal screening procedures for virus‐infected pregnant patients.
Materialart:
Online-Ressource
ISSN:
2050-0068
,
2050-0068
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
2019
ZDB Id:
2694482-0
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