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  • 1
    Online Resource
    Online Resource
    Involvement of P-glycoprotein in the transmembrane transport of interleukin-2 (IL-2), IL-4, and interferon-gamma in normal human T lymphocytes
    American Society of Hematology ; 1996
    In:  Blood Vol. 88, No. 5 ( 1996-09-01), p. 1747-1754
    Details
    In: Blood, American Society of Hematology, Vol. 88, No. 5 ( 1996-09-01), p. 1747-1754
    Abstract: The physiological role of the multidrug resistance P-glycoprotein (P- gp), which is expressed by normal human T lymphocytes, is still largely unknown. To investigate whether or not P-gp is involved in the transport of cytokines, peripheral blood lymphocytes were stimulated with phytohemagglutinin (PHA) in the absence or presence of P-gp inhibitors, and concentrations of cytokines (interleukin-2 [IL-2], IL- 4, IL-6, interferon-gamma [IFN-gamma] ) in the supernatants of these cultures were quantitated by enzyme-linked immunosorbent assay. P-gp inhibitors included verapamil (Ver), tamoxifen (Tmx), and the P-gp specific monoclonal antibody UIC2. Release of IL-2 was significantly suppressed by these inhibitors at concentrations that were also effective in blocking efflux of Rhodamine-123 from normal T lymphocytes. IL-2 mRNA expression in lymphocytes was not different between PHA control and the cultures with P-gp inhibitors. Ver and Tmx did not interfere with T-cell activation as determined by CD25 and CD69 expression. In a nonhematological model, the P-gp expressing HCT-8 adenocarcinoma cell line, exogenously added IL-2 was shown to exert an inhibitory effect on P-gp mediated Rhodamine-123 efflux. In addition, transepithelial transport of IL-2 by electrophysiologically tight and polarized HCT-8 monolayers was examined. A time-dependent flux of IL-2 across dense monolayers, which was partially inhibited by Ver, was observed. We also investigated whether or not P-gp inhibitors suppressed release of other cytokines produced by activated T cells (IL- 4, IL-6, IFN-gamma). Release of IL-4 and IFN-gamma was significantly inhibited by Ver, Tmx, and UIC2; however, release of IL-6 remained unaffected. These data show P-gp mediated transmembrane flux of IL-2 in T lymphocytes and HCT-8 cells. We conclude that P-gp participates in the transport of cytokines (IL-2, IL-4, and IFN-gamma) in normal peripheral T lymphocytes.
    Type of Medium: Online Resource
    ISSN: 0006-4971 , 1528-0020
    URL: Article
    DOI: 10.1182/blood.V88.5.1747.1747
    RVK:
    XA 33000
    RVK:
    XA 10000
    Language: English
    Publisher: American Society of Hematology
    Publication Date: 1996
    detail.hit.zdb_id: 1468538-3
    detail.hit.zdb_id: 80069-7
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  • 2
    Online Resource
    Online Resource
    Interphase fluorescence in situ hybridization identifies chromosomal abnormalities in plasma cells from patients with monoclonal gammopathy of undetermined significance
    American Society of Hematology ; 1995
    In:  Blood Vol. 86, No. 10 ( 1995-11-15), p. 3915-3921
    Details
    In: Blood, American Society of Hematology, Vol. 86, No. 10 ( 1995-11-15), p. 3915-3921
    Abstract: Karyotypic studies in patients with monoclonal gammopathy of undetermined significance (MGUS) have been hampered by a low percentage of bone marrow plasma cells (BMPC), which are predominantly nonproliferating. By combining cytomorphology and interphase fluorescence in situ hybridization (FISH) we investigated whether or not chromosomal abnormalities occur in BMPC from patients with MGUS. Studying chromosomes 3, 7, 11, and 18, which we found to be frequently aneuploid by FISH in multiple myeloma (MM), we observed three hybridization signals for one of these chromosomes 3 were most common, occurring in 38.9% of patients, followed by gains of chromosomes 11 (25%), 7 (16.7%), and 18 (5.6%) Among BMPC, the frequency of aneuploid cells was 18.9% +/- 13.9% (mean +/- SD) for chromosome 3, 22.3% +/- 9.2% for chromosome 11, 23.2% +/- 22.0% for chromosome 7, and 6.1% +/- 2.3% for chromosome 18. In five patients, chromosomal abnormalities were shown to be restricted to BMPC expressing cytoplasmic immunoglobulins corresponding to the serum paraprotein. No gain of hybridization signals was observed in normal and reactive plasma cells. In one patient with MGUS, metaphase cytogenetics revealed one abnormal metaphase with 47, XY, +4, and trisomy 4 was also demonstrated in a subpopulation of BMPC by interphase FISH. FISH results from patients with MGUS and newly diagnosed MM at stage IA (n = 14) indicated that aberrations involving 〉 or = 2 chromosomes occurred significantly more often in early stage MM (P 〈 .01). With respect to clinical and laboratory features, MGUS patients with and without chromosomal abnormalities were indistinguishable. Our results indicate that MGUS already has the chromosomal characteristics of a plasma cell malignancy.
    Type of Medium: Online Resource
    ISSN: 0006-4971 , 1528-0020
    URL: Article
    DOI: 10.1182/blood.V86.10.3915.bloodjournal86103915
    RVK:
    XA 33000
    RVK:
    XA 10000
    Language: English
    Publisher: American Society of Hematology
    Publication Date: 1995
    detail.hit.zdb_id: 1468538-3
    detail.hit.zdb_id: 80069-7
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  • 3
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    Online Resource
    Book Reviews
    Brill ; 1998
    In:  Bijdragen tot de taal-, land- en volkenkunde / Journal of the Humanities and Social Sciences of Southeast Asia Vol. 154, No. 1 ( 1998), p. 150-177
    Details
    In: Bijdragen tot de taal-, land- en volkenkunde / Journal of the Humanities and Social Sciences of Southeast Asia, Brill, Vol. 154, No. 1 ( 1998), p. 150-177
    Abstract: - J. Angerler, Jýrg Schneider, From upland to irrigated rice; The development of wet-rice agriculture in Rejang Musi, Southwest Sumatra. Berlin: Reimer, 1995, 214 pp. [Berner Sumatra-Forschungen.] - R.H. Barnes, Janet Hoskins, The play of time; Kodi perspectives on calendars, history, and exchange. Berkeley: University of California Press, 1993, xx + 414 pp. - Karin Bras, Christel Lýbben, Internationaler Tourismus als Faktor der Regionalentwicklung in Indonesien; Untersucht am Beispiel der Insel Lombok. Berlin: Dietrich Reimer, 1995, xiv + 178 pp. - Peter Boomgaard, Florentino Rodao, Espaýoles en Siam (1540-1939); Una aportaciýn al estudio de la presencia hispana en Asia Oriental. Madrid: Consejo Superior de Investigaciones Cientýficas, 1997, xix + 206 pp. [Biblioteca de Historia 32.] - Hans Hýgerdal, Winarsih Partaningrat Arifin, Babad Sembar; Chroniques de lýest javanais. Paris: Presses de lýýcole Francaise dýExtrýme Orient, 1995, 149 pp. [EFEO monographie 177.] - Els M. Jacobs, Gerrit J. Knaap, Shallow waters, rising tide; Shipping and trade in Java around 1775. Leiden: KITLV Press, 1996. [Verhandelingen van het Koninklijk Instituut voor Taal-, Land- en Volkenkunde 172.] - Roy E. Jordaan, John Miksic, Ancient history. Singapore: Archipelago Press/Editions Didier Millet, n.d., 148 pp. [The Indonesian Heritage Series 1.] - Victor T. King, Penelope Graham, Iban shamanism; An analysis of the ethnographic literature. Canberra: Department of Anthropology, Research School of Pacific Studies, Australian National University, 1987 (reprint 1994), x + 174 pp. [Occasional Paper.] - Rita Smith Kipp, Simon Rae, Breath becomes the wind; Old and new in Karo religion. Dunedin: University of Otago Press, 1994, viii + 306 pp. - Niels Mulder, Raul Pertierra, Explorations in social theory and Philippine ethnography. Quezon City: University of the Philippines Press, 1997, xii + 262 pp. - Anthony Reid, Luc Nagtegaal, Riding the Dutch tiger; The Dutch East Indies Company and the northeast coast of Java, 1680-1743 (translated by Beverly Jackson). Leiden: KITLV Press, 1996, x + 250 pp. Index, maps, tables, graphs. - Cornelia M.I. van der Sluys, Signe Howell, For the sake of our future; Sacrificing in eastern Indonesia, Leiden: Centre for Non-Western Studies, 1996, xi + 398 pp. [CNWS Publication 42.] - Jaap Timmer, Bernard Juillerat, Children of the blood; Society, reproduction and cosmology in New Guinea (translated from the French by Nora Scott). Oxford: Berg, 1996, xxx + 601 pp., glossary, bibliography, index. [Explorations in Anthropology.]
    Type of Medium: Online Resource
    ISSN: 0006-2294 , 2213-4379
    URL: Article
    DOI: 10.1163/22134379-90003909
    Language: Unknown
    Publisher: Brill
    Publication Date: 1998
    detail.hit.zdb_id: 2484489-5
    SSG: 7,23
    SSG: 10
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  • 4
    Online Resource
    Online Resource
    Involvement of P-glycoprotein in the transmembrane transport of interleukin-2 (IL-2), IL-4, and interferon-gamma in normal human T lymphocytes
    American Society of Hematology ; 1996
    In:  Blood Vol. 88, No. 5 ( 1996-09-01), p. 1747-1754
    Details
    In: Blood, American Society of Hematology, Vol. 88, No. 5 ( 1996-09-01), p. 1747-1754
    Abstract: The physiological role of the multidrug resistance P-glycoprotein (P- gp), which is expressed by normal human T lymphocytes, is still largely unknown. To investigate whether or not P-gp is involved in the transport of cytokines, peripheral blood lymphocytes were stimulated with phytohemagglutinin (PHA) in the absence or presence of P-gp inhibitors, and concentrations of cytokines (interleukin-2 [IL-2], IL- 4, IL-6, interferon-gamma [IFN-gamma] ) in the supernatants of these cultures were quantitated by enzyme-linked immunosorbent assay. P-gp inhibitors included verapamil (Ver), tamoxifen (Tmx), and the P-gp specific monoclonal antibody UIC2. Release of IL-2 was significantly suppressed by these inhibitors at concentrations that were also effective in blocking efflux of Rhodamine-123 from normal T lymphocytes. IL-2 mRNA expression in lymphocytes was not different between PHA control and the cultures with P-gp inhibitors. Ver and Tmx did not interfere with T-cell activation as determined by CD25 and CD69 expression. In a nonhematological model, the P-gp expressing HCT-8 adenocarcinoma cell line, exogenously added IL-2 was shown to exert an inhibitory effect on P-gp mediated Rhodamine-123 efflux. In addition, transepithelial transport of IL-2 by electrophysiologically tight and polarized HCT-8 monolayers was examined. A time-dependent flux of IL-2 across dense monolayers, which was partially inhibited by Ver, was observed. We also investigated whether or not P-gp inhibitors suppressed release of other cytokines produced by activated T cells (IL- 4, IL-6, IFN-gamma). Release of IL-4 and IFN-gamma was significantly inhibited by Ver, Tmx, and UIC2; however, release of IL-6 remained unaffected. These data show P-gp mediated transmembrane flux of IL-2 in T lymphocytes and HCT-8 cells. We conclude that P-gp participates in the transport of cytokines (IL-2, IL-4, and IFN-gamma) in normal peripheral T lymphocytes.
    Type of Medium: Online Resource
    ISSN: 0006-4971 , 1528-0020
    URL: Article
    DOI: 10.1182/blood.V88.5.1747.bloodjournal8851747
    RVK:
    XA 33000
    RVK:
    XA 10000
    Language: English
    Publisher: American Society of Hematology
    Publication Date: 1996
    detail.hit.zdb_id: 1468538-3
    detail.hit.zdb_id: 80069-7
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  • 5
    Online Resource
    Online Resource
    Interphase fluorescence in situ hybridization improves the detection of malignant cells in effusions from breast cancer patients
    Springer Science and Business Media LLC ; 1997
    In:  British Journal of Cancer Vol. 75, No. 3 ( 1997-2), p. 403-407
    Details
    In: British Journal of Cancer, Springer Science and Business Media LLC, Vol. 75, No. 3 ( 1997-2), p. 403-407
    Type of Medium: Online Resource
    ISSN: 0007-0920 , 1532-1827
    URL: Article
    DOI: 10.1038/bjc.1997.65
    RVK:
    XA 33500
    RVK:
    XA 10000
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 1997
    detail.hit.zdb_id: 2002452-6
    detail.hit.zdb_id: 80075-2
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  • 6
    Online Resource
    Online Resource
    A survey on current knowledge, practice and beliefs related to preoperative antimicrobial decolonization regimens for prevention of surgical site infections among Austrian surgeons
    Elsevier BV ; 2018
    In:  Journal of Hospital Infection Vol. 100, No. 4 ( 2018-12), p. 386-392
    Details
    In: Journal of Hospital Infection, Elsevier BV, Vol. 100, No. 4 ( 2018-12), p. 386-392
    Type of Medium: Online Resource
    ISSN: 0195-6701
    URL: Article
    DOI: 10.1016/j.jhin.2018.07.019
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2018
    detail.hit.zdb_id: 2002429-0
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  • 7
    Online Resource
    Online Resource
    Book Reviews
    Brill ; 1995
    In:  Bijdragen tot de taal-, land- en volkenkunde / Journal of the Humanities and Social Sciences of Southeast Asia Vol. 151, No. 1 ( 1995), p. 136-161
    Details
    In: Bijdragen tot de taal-, land- en volkenkunde / Journal of the Humanities and Social Sciences of Southeast Asia, Brill, Vol. 151, No. 1 ( 1995), p. 136-161
    Abstract: - Johann Angerler, Masashi Hirosue, Prophets and followers in Batak millenarian responses to the colonial order; Parmalim, Na Siak Bagi and Parhudamdam, 1890-1930. Ph.D. thesis Australian National University, Canberra, 1988. - J. ter Beek, H. Cordes, Pencak silat; Die Kampfunst der Minangkabau und ihr kulturelles Umfeld. Frankfurt a.M.: Afra Verlag, 1992, 320 pp. - Peter Boomgaard, J.A.A. van Doorn, De laatste eeuw van Indië; Ontwikkeling en ondergang van een koloniaal project. Amsterdam: Bert Bakker, 1994, 370 pp. - J.G. de Casparis, Georges Condominas, Disciplines croisées; Hommage à Bernard Philippe Groslier. Paris: Éditions de l’École des Hautes Études en Sciences Sociales, 1992, 377 pp. - H.J.M. Claessen, Ton Otto, Pacific Islands trajectories; Five personal views, Occasional paper of the Department of Anthropology, Research School of Pacific Studies, The Australian University (Canberra), in association with the Centre for Pacific Studies, University of Nijmegen, The Netherlands. - Bruce Connell, Cecilia Odé, Experimental studies of Indonesian prosody. Semaian 9. Leiden: Vakgroep Talen en Culturen van Zuidoost-Azië en Oceanië, 1994, 214 pp., Vincent J. van Heuven (eds.) - Aone van Engelenhoven, Donald A. Burquest, Descriptive studies in languages of Maluku. NUSA, Linguistic Studies of Indonesian and other Languages in Indonesia, volume 34. Jakarta: Badan Penyelenggara Seri Nusa, Universitas Katolik Indonesia Atma Jaya, 1992, x + 94 pp., maps., Wyn D. Laidig (eds.) - Ch. F. van Fraassen, Dieter Bartels, In de schaduw van de berg Nunusaku; Een cultuur-historische verhandeling over de bevolking van de Midden-Molukken. Utrecht: Landelijk Steunpunt Edukatie Molukkers, 1994, 476 pp. - C.D. Grijns, Don Kulick, Language shift and cultural reproduction; Socialization, self, and syncretism in a Papua New Guinean village. Cambridge/New York/Victoria: Cambridge University Press, 1992, xvi + 317 pp., maps, figures, photographs, index. - Tim Hoppen, Gerard Termorshuizen, In de binnenland van Java; Vier negentiende-eeuwse reisverhalen. Leiden: KITLV Uitgeverij, 1993, 102 pp. - Niels Mulder, Monique Zaini-Lajoubert, L’image de la femme dans les littératures modernes indonésienne et malaise. Paris: Association Archipel, Cahier d’Archipel 24, 1994, ix + 221 pp. - A. Niehof, Rosalia Sciortino, CARE-takers of CURE; A study of health centre nurses in rural Central Java. Amsterdam: Jolly/Het Spinhuis Publishers, 1992, 318 pp. - A.J. Plaisier, B. Plaisier, Over bruggen en grenzen; De communicatie van het evangelie in het Torajagebied (1913-1942). Zoetermeer: Boekencentrum, 1993, xiv + 701 pp. - Anton Ploeg, Nonie Sharp, The Morning Star in Papua Barat, written in association with Markus Wonggor Kaisiëpo. North Carlton, Vic., Australia: Arena Publications, 1994, xx + 140 pp.
    Type of Medium: Online Resource
    ISSN: 0006-2294 , 2213-4379
    URL: Article
    DOI: 10.1163/22134379-90003062
    Language: Unknown
    Publisher: Brill
    Publication Date: 1995
    detail.hit.zdb_id: 2484489-5
    SSG: 7,23
    SSG: 10
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