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Precursor Lesions in Patients With Multiple Endocrine Neoplasia Type 1--Associated Duodenal Gastrinomas

Anlauf, Martin ; Perren, Aurel ; Meyer, Cora Lu ; [et al.]

Elsevier BV ; 2005

In: Gastroenterology Vol. 128, No. 5 ( 2005-5), p. 1187-1198

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In: Gastroenterology, Elsevier BV, Vol. 128, No. 5 ( 2005-5), p. 1187-1198

Type of Medium: Online Resource

ISSN: 0016-5085

URL: Article

DOI: 10.1053/j.gastro.2005.01.058

RVK:

XA 44500

Language: English

Publisher: Elsevier BV

Publication Date: 2005

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BAY-7081: A Potent, Selective, and Orally Bioavailable Cyanopyridone-Based PDE9A Inhibitor

Meibom, Daniel ; Micus, Sina ; Andreevski, Anna Lena ; [et al.]

American Chemical Society (ACS) ; 2022

In: Journal of Medicinal Chemistry Vol. 65, No. 24 ( 2022-12-22), p. 16420-16431

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In: Journal of Medicinal Chemistry, American Chemical Society (ACS), Vol. 65, No. 24 ( 2022-12-22), p. 16420-16431

Type of Medium: Online Resource

ISSN: 0022-2623 , 1520-4804

URL: Article

DOI: 10.1021/acs.jmedchem.2c01267

DOI: 10.1021/acs.jmedchem.2c01267.s001

DOI: 10.1021/acs.jmedchem.2c01267.s002

Language: English

Publisher: American Chemical Society (ACS)

Publication Date: 2022

detail.hit.zdb_id: 1491411-6

SSG: 15,3

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Islet 1 (Isl1) Expression is a Reliable Marker for Pancreatic Endocrine Tumors and Their Metastases

Schmitt, Anja M. ; Riniker, Florian ; Anlauf, Martin ; [et al.]

Ovid Technologies (Wolters Kluwer Health) ; 2008

In: American Journal of Surgical Pathology Vol. 32, No. 3 ( 2008-03), p. 420-425

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In: American Journal of Surgical Pathology, Ovid Technologies (Wolters Kluwer Health), Vol. 32, No. 3 ( 2008-03), p. 420-425

Type of Medium: Online Resource

ISSN: 0147-5185

URL: Article

DOI: 10.1097/PAS.0b013e318158a397

RVK:

XA 10000

Language: English

Publisher: Ovid Technologies (Wolters Kluwer Health)

Publication Date: 2008

detail.hit.zdb_id: 2029143-7

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A New Class of Organosoluble Rigid-Rod, Fully Aromatic Poly(1,3,4-oxadiazole)s and Their Solid-State Properties, 2. Solid-State Properties

Janietz, Silvia ; Anlauf, Sonja ; Wedel, Armin

Wiley ; 2002

In: Macromolecular Chemistry and Physics Vol. 203, No. 2 ( 2002-01-01), p. 433-438

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In: Macromolecular Chemistry and Physics, Wiley, Vol. 203, No. 2 ( 2002-01-01), p. 433-438

Type of Medium: Online Resource

ISSN: 1022-1352 , 1521-3935

URL: Issue

URL: Journal

URL: Article

DOI: 10.1002/1521-3935(20020101)203:2〈〉1.0.CO;2-P

DOI: 10.1002/(ISSN)1521-3935

DOI: 10.1002/1521-3935(20020101)203:2〈433::AID-MACP433〉3.0.CO;2-J

RVK:

VA 5810

Language: English

Publisher: Wiley

Publication Date: 2002

detail.hit.zdb_id: 1475026-0

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Structure and Total Synthesis of Lysobactin (Katanosin B)

von Nussbaum, Franz ; Anlauf, Sonja ; Benet-Buchholz, Jordi ; [et al.]

Wiley ; 2007

In: Angewandte Chemie Vol. 119, No. 12 ( 2007-03-12), p. 2085-2088

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In: Angewandte Chemie, Wiley, Vol. 119, No. 12 ( 2007-03-12), p. 2085-2088

Type of Medium: Online Resource

ISSN: 0044-8249 , 1521-3757

URL: Issue

URL: Journal

URL: Article

DOI: 10.1002/ange.v119:12

DOI: 10.1002/(ISSN)1521-3757

DOI: 10.1002/ange.200604232

RVK:

VA 2100

RVK:

VN 5020

Language: German

Publisher: Wiley

Publication Date: 2007

detail.hit.zdb_id: 505868-5

detail.hit.zdb_id: 506609-8

detail.hit.zdb_id: 514305-6

detail.hit.zdb_id: 505872-7

detail.hit.zdb_id: 1479266-7

detail.hit.zdb_id: 505867-3

detail.hit.zdb_id: 506259-7

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Total Synthesis and Initial Structure–Activity Relationships of Longicatenamycin A

von Nussbaum, Franz ; Anlauf, Sonja ; Freiberg, Christoph ; [et al.]

Wiley ; 2008

In: ChemMedChem Vol. 3, No. 4 ( 2008-04-14), p. 619-626

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In: ChemMedChem, Wiley, Vol. 3, No. 4 ( 2008-04-14), p. 619-626

Abstract: Natural products have provided the majority of lead structures for marketed antibacterials. In addition, they are biological guide principles to new therapies. Nevertheless, numerous “old” classes of antibiotics such as the longicatenamycins have never been explored by chemical postevolution. Longicatenamycin A is the first defined longicatenamycin congener that has been totally synthesized and tested in pure form. This venture required the de novo syntheses of the non‐proteinogenic amino acids (2 S ,3 R )‐β‐hydroxyglutamic acid (HyGlu), 5‐chloro‐ D ‐tryptophan ( D ‐ClTrp), and ( S )‐2‐amino‐6‐methylheptanoic acid (hhLeu). In the key step, the sensitive HyGlu building block was coupled as a pentafluorophenyl active ester to the unprotected H‐ D ‐ClTrp‐Glu‐hhLeu‐ D ‐Val‐ D ‐(Cbz)Orn‐OH fragment. This first total synthesis of longicatenamycin A provided new congeners of the natural product (deacetyllongicatenamycin, dechlorolongicatenamycin, and longicatenamycin‐A‐amide).

Type of Medium: Online Resource

ISSN: 1860-7179 , 1860-7187

URL: Issue

URL: Article

DOI: 10.1002/cmdc.v3:4

DOI: 10.1002/cmdc.200700297

RVK:

VA 3569

Language: English

Publisher: Wiley

Publication Date: 2008

detail.hit.zdb_id: 2209649-8

SSG: 15,3

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Freezing the Bioactive Conformation to Boost Potency: The Identification of BAY 85-8501, a Selective and Potent Inhibitor of Human Neutrophil Elastase for Pulmonary Diseases

von Nussbaum, Franz ; Li, Volkhart M.-J. ; Allerheiligen, Swen ; [et al.]

Wiley ; 2015

In: ChemMedChem Vol. 10, No. 7 ( 2015-07), p. 1163-1173

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In: ChemMedChem, Wiley, Vol. 10, No. 7 ( 2015-07), p. 1163-1173

Type of Medium: Online Resource

ISSN: 1860-7179

URL: Issue

URL: Article

DOI: 10.1002/cmdc.v10.7

DOI: 10.1002/cmdc.201500131

RVK:

VA 3569

Language: English

Publisher: Wiley

Publication Date: 2015

detail.hit.zdb_id: 2209649-8

SSG: 15,3

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Structure and Total Synthesis of Lysobactin (Katanosin B).

von Nussbaum, Franz ; Anlauf, Sonja ; Benet-Buchholz, Jordi ; [et al.]

Wiley ; 2007

In: ChemInform Vol. 38, No. 22 ( 2007-05-29)

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In: ChemInform, Wiley, Vol. 38, No. 22 ( 2007-05-29)

Type of Medium: Online Resource

ISSN: 0931-7597 , 1522-2667

URL: Issue

URL: Journal

URL: Article

DOI: 10.1002/chin.v38:22

DOI: 10.1002/(ISSN)1522-2667

DOI: 10.1002/chin.200722195

Language: English

Publisher: Wiley

Publication Date: 2007

detail.hit.zdb_id: 2110203-X

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Cover Picture: Freezing the Bioactive Conformation to Boost Potency: The Identification of BAY 85-8501, a Selective and Potent Inhibitor of Human Neutrophil Elastase for Pulmonary Diseases (ChemMedChem 7/2015)

von Nussbaum, Franz ; Li, Volkhart M.-J. ; Allerheiligen, Swen ; [et al.]

Wiley ; 2015

In: ChemMedChem Vol. 10, No. 7 ( 2015-07), p. 1117-1117

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In: ChemMedChem, Wiley, Vol. 10, No. 7 ( 2015-07), p. 1117-1117

Type of Medium: Online Resource

ISSN: 1860-7179

URL: Issue

URL: Article

DOI: 10.1002/cmdc.v10.7

DOI: 10.1002/cmdc.201590019

RVK:

VA 3569

Language: English

Publisher: Wiley

Publication Date: 2015

detail.hit.zdb_id: 2209649-8

SSG: 15,3

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Potent and Selective Human Neutrophil Elastase Inhibitors with Novel Equatorial Ring Topology: in vivo Efficacy of the Polar Pyrimidopyridazine BAY‐8040 in a Pulmonary Arterial Hypertension Rat Model

von Nussbaum, Franz ; Li, Volkhart M. ; Meibom, Daniel ; [et al.]

Wiley ; 2016

In: ChemMedChem Vol. 11, No. 2 ( 2016-01), p. 199-206

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In: ChemMedChem, Wiley, Vol. 11, No. 2 ( 2016-01), p. 199-206

Abstract: Human neutrophil elastase (HNE) is a key driver of inflammation in many cardiopulmonary and systemic inflammatory and autoimmune conditions. Overshooting high HNE activity is the consequence of a disrupted protease–antiprotease balance. Accordingly, there has been an intensive search for potent and selective HNE inhibitors with suitable pharmacokinetics that would allowing oral administration in patients. Based on the chemical probe BAY‐678 and the clinical candidate BAY 85‐8501 we explored further ring topologies along the equator of the parent pyrimidinone lead series. Novel ring systems were annulated in the east, yielding imidazolo‐, triazolo‐, and tetrazolopyrimidines in order to ensure additional inhibitor–HNE contacts beyond the S1 and the S2 pocket of HNE. The western annulation of pyridazines led to the polar pyrimidopyridazine BAY‐8040, which combines excellent potency and selectivity with a promising pharmacokinetic profile. In vivo efficacy with regard to decreasing cardiac remodeling and amelioration of cardiac function was shown in a monocrotaline‐induced rat model for pulmonary arterial hypertension. This demonstrated in vivo proof of concept in animals.

Type of Medium: Online Resource

ISSN: 1860-7179 , 1860-7187

URL: Issue

URL: Article

DOI: 10.1002/cmdc.v11.2

DOI: 10.1002/cmdc.201500269

RVK:

VA 3569

Language: English

Publisher: Wiley

Publication Date: 2016

detail.hit.zdb_id: 2209649-8

SSG: 15,3

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