In:
Rapid Communications in Mass Spectrometry, Wiley, Vol. 19, No. 9 ( 2005-05-15), p. 1200-1206
Abstract:
The electron ionization induced fragmentations of ten biologically significant 2,3‐dihydro‐1,5‐benzothiazepines and the corresponding 2,3,4,5‐tetrahydro‐1,5‐benzothiazepines have been studied by low‐ and high‐resolution mass spectrometry. The fragmentations follow a general pattern, the details of which are discussed with respect to the nature and position of the substituent in the aromatic ring. The dihydro‐ and tetrahydro‐1,5‐benzothiazepines both undergo fragmentation through four routes (A–D). However, the most significant fragmentation takes place through route A, leading to the elimination of ring A or ring B of the molecule. The difference between the fragmentation patterns of dihydro‐ and tetrahydro‐1,5‐benzothiazepines appears mainly in route E where a phenylallylhydroxybenzene cation appears in all tetrahydro‐1,5‐benzothiazepines but is not observed in the corresponding dihydro derivatives. Copyright © 2005 John Wiley & Sons, Ltd.
Type of Medium:
Online Resource
ISSN:
0951-4198
,
1097-0231
Language:
English
Publisher:
Wiley
Publication Date:
2005
detail.hit.zdb_id:
2002158-6
detail.hit.zdb_id:
58731-X
SSG:
11
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