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CIP2A Promotes T-Cell Activation and Immune Response to Listeria monocytogenes Infection

Côme, Christophe ; Cvrljevic, Anna ; Khan, Mohd Moin ; [et al.]

Public Library of Science (PLoS) ; 2016

In: PLOS ONE Vol. 11, No. 4 ( 2016-4-21), p. e0152996-

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In: PLOS ONE, Public Library of Science (PLoS), Vol. 11, No. 4 ( 2016-4-21), p. e0152996-

Type of Medium: Online Resource

ISSN: 1932-6203

URL: Article

DOI: 10.1371/journal.pone.0152996

DOI: 10.1371/journal.pone.0152996.g001

DOI: 10.1371/journal.pone.0152996.g002

DOI: 10.1371/journal.pone.0152996.g003

DOI: 10.1371/journal.pone.0152996.g004

DOI: 10.1371/journal.pone.0152996.t001

DOI: 10.1371/journal.pone.0152996.t002

DOI: 10.1371/journal.pone.0152996.t003

DOI: 10.1371/journal.pone.0152996.s001

DOI: 10.1371/journal.pone.0152996.s002

DOI: 10.1371/journal.pone.0152996.s003

DOI: 10.1371/journal.pone.0152996.s004

DOI: 10.1371/journal.pone.0152996.s005

DOI: 10.1371/journal.pone.0152996.s006

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2016

detail.hit.zdb_id: 2267670-3

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Cox4i2, Ifit2, and Prdm11 Mutant Mice: Effective Selection of Genes Predisposing to an Altered Airway Inflammatory Response from a Large Compendium of Mutant Mouse Lines

Horsch, Marion ; Aguilar-Pimentel, Juan Antonio ; Bönisch, Clemens ; [et al.]

Public Library of Science (PLoS) ; 2015

In: PLOS ONE Vol. 10, No. 8 ( 2015-8-11), p. e0134503-

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In: PLOS ONE, Public Library of Science (PLoS), Vol. 10, No. 8 ( 2015-8-11), p. e0134503-

Type of Medium: Online Resource

ISSN: 1932-6203

URL: Article

DOI: 10.1371/journal.pone.0134503

DOI: 10.1371/journal.pone.0134503.g001

DOI: 10.1371/journal.pone.0134503.g002

DOI: 10.1371/journal.pone.0134503.g003

DOI: 10.1371/journal.pone.0134503.g004

DOI: 10.1371/journal.pone.0134503.g005

DOI: 10.1371/journal.pone.0134503.g006

DOI: 10.1371/journal.pone.0134503.t001

DOI: 10.1371/journal.pone.0134503.t002

DOI: 10.1371/journal.pone.0134503.t003

DOI: 10.1371/journal.pone.0134503.s001

DOI: 10.1371/journal.pone.0134503.s002

DOI: 10.1371/journal.pone.0134503.s003

DOI: 10.1371/journal.pone.0134503.s004

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2015

detail.hit.zdb_id: 2267670-3

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Mouse phenotyping

Fuchs, Helmut ; Gailus-Durner, Valérie ; Adler, Thure ; [et al.]

Elsevier BV ; 2011

In: Methods Vol. 53, No. 2 ( 2011-02), p. 120-135

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In: Methods, Elsevier BV, Vol. 53, No. 2 ( 2011-02), p. 120-135

Type of Medium: Online Resource

ISSN: 1046-2023

URL: Article

DOI: 10.1016/j.ymeth.2010.08.006

Language: English

Publisher: Elsevier BV

Publication Date: 2011

detail.hit.zdb_id: 1471152-7

SSG: 12

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The heterozygous R155C VCP mutation: Toxic in humans! Harmless in mice?

Clemen, Christoph S. ; Winter, Lilli ; Strucksberg, Karl-Heinz ; [et al.]

Elsevier BV ; 2018

In: Biochemical and Biophysical Research Communications Vol. 503, No. 4 ( 2018-09), p. 2770-2777

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In: Biochemical and Biophysical Research Communications, Elsevier BV, Vol. 503, No. 4 ( 2018-09), p. 2770-2777

Type of Medium: Online Resource

ISSN: 0006-291X

URL: Article

DOI: 10.1016/j.bbrc.2018.08.038

RVK:

WA 15000

Language: English

Publisher: Elsevier BV

Publication Date: 2018

detail.hit.zdb_id: 1461396-7

SSG: 12

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Myoscape controls cardiac calcium cycling and contractility via regulation of L-type calcium channel surface expression

Eden, Matthias ; Meder, Benjamin ; Völkers, Mirko ; [et al.]

Springer Science and Business Media LLC ; 2016

In: Nature Communications Vol. 7, No. 1 ( 2016-04-28)

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In: Nature Communications, Springer Science and Business Media LLC, Vol. 7, No. 1 ( 2016-04-28)

Abstract: Calcium signalling plays a critical role in the pathogenesis of heart failure. Here we describe a cardiac protein named Myoscape/FAM40B/STRIP2, which directly interacts with the L-type calcium channel. Knockdown of Myoscape in cardiomyocytes decreases calcium transients associated with smaller Ca 2+ amplitudes and a lower diastolic Ca 2+ content. Likewise, L-type calcium channel currents are significantly diminished on Myoscape ablation, and downregulation of Myoscape significantly reduces contractility of cardiomyocytes. Conversely, overexpression of Myoscape increases global Ca 2+ transients and enhances L-type Ca 2+ channel currents, and is sufficient to restore decreased currents in failing cardiomyocytes. In vivo , both Myoscape-depleted morphant zebrafish and Myoscape knockout (KO) mice display impairment of cardiac function progressing to advanced heart failure. Mechanistically, Myoscape-deficient mice show reduced L-type Ca 2+ currents, cell capacity and calcium current densities as a result of diminished LTCC surface expression. Finally, Myoscape expression is reduced in hearts from patients suffering of terminal heart failure, implying a role in human disease.

Type of Medium: Online Resource

ISSN: 2041-1723

URL: Article

DOI: 10.1038/ncomms11317

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2016

detail.hit.zdb_id: 2553671-0

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Surface modifications of silica nanoparticles are crucial for their inert versus proinflammatory and immunomodulatory properties

Alessandrini ; Aguilar Pimentel, Juan Antonio ; Landsiedel, Robert ; [et al.]

Informa UK Limited ; 2014

In: International Journal of Nanomedicine

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In: International Journal of Nanomedicine, Informa UK Limited

Type of Medium: Online Resource

ISSN: 1178-2013

URL: Journal

URL: Article

DOI: 10.2147/IJN

DOI: 10.2147/IJN.S57396

Language: English

Publisher: Informa UK Limited

Publication Date: 2014

detail.hit.zdb_id: 2377464-2

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Innovations in phenotyping of mouse models in the German Mouse Clinic

Fuchs, Helmut ; Gailus-Durner, Valérie ; Neschen, Susanne ; [et al.]

Springer Science and Business Media LLC ; 2012

In: Mammalian Genome Vol. 23, No. 9-10 ( 2012-10), p. 611-622

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In: Mammalian Genome, Springer Science and Business Media LLC, Vol. 23, No. 9-10 ( 2012-10), p. 611-622

Type of Medium: Online Resource

ISSN: 0938-8990 , 1432-1777

URL: Article

DOI: 10.1007/s00335-012-9415-1

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2012

detail.hit.zdb_id: 1459397-X

SSG: 12

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A mouse model for intellectual disability caused by mutations in the X-linked 2′‑O‑methyltransferase Ftsj1 gene

Jensen, Lars R. ; Garrett, Lillian ; Hölter, Sabine M. ; [et al.]

Elsevier BV ; 2019

In: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease Vol. 1865, No. 9 ( 2019-09), p. 2083-2093

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In: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Elsevier BV, Vol. 1865, No. 9 ( 2019-09), p. 2083-2093

Type of Medium: Online Resource

ISSN: 0925-4439

URL: Article

DOI: 10.1016/j.bbadis.2018.12.011

RVK:

WA 15000

Language: English

Publisher: Elsevier BV

Publication Date: 2019

detail.hit.zdb_id: 2209528-7

SSG: 12

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Requirement of the RNA-editing Enzyme ADAR2 for Normal Physiology in Mice

Horsch, Marion ; Seeburg, Peter H. ; Adler, Thure ; [et al.]

Elsevier BV ; 2011

In: Journal of Biological Chemistry Vol. 286, No. 21 ( 2011-05), p. 18614-18622

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In: Journal of Biological Chemistry, Elsevier BV, Vol. 286, No. 21 ( 2011-05), p. 18614-18622

Type of Medium: Online Resource

ISSN: 0021-9258

URL: Article

DOI: 10.1074/jbc.M110.200881

Language: English

Publisher: Elsevier BV

Publication Date: 2011

detail.hit.zdb_id: 2141744-1

detail.hit.zdb_id: 1474604-9

SSG: 12

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High Mobility Group N Proteins Modulate the Fidelity of the Cellular Transcriptional Profile in a Tissue- and Variant-specific Manner

Kugler, Jamie E. ; Horsch, Marion ; Huang, Di ; [et al.]

Elsevier BV ; 2013

In: Journal of Biological Chemistry Vol. 288, No. 23 ( 2013-06), p. 16690-16703

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In: Journal of Biological Chemistry, Elsevier BV, Vol. 288, No. 23 ( 2013-06), p. 16690-16703

Type of Medium: Online Resource

ISSN: 0021-9258

URL: Article

DOI: 10.1074/jbc.M113.463315

Language: English

Publisher: Elsevier BV

Publication Date: 2013

detail.hit.zdb_id: 2141744-1

detail.hit.zdb_id: 1474604-9

SSG: 12

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