In:
EMBO reports, EMBO, Vol. 23, No. 9 ( 2022-09-05)
Abstract:
image The RNA‐binding protein hnRNP R inhibits P‐TEFb‐mediated phosphorylation of RNA polymerase II, thereby modulating transcription. P‐TEFb remodelling and release from 7SK in an hnRNP R‐dependent manner contribute to this effect. Cells lacking hnRNP R show increased transcription accompanied by enhanced phosphorylation of Serine 2 of the C‐terminal domain of RNA polymerase II. Deficiency of hnRNP R induces release of P‐TEFb from the inhibitory non‐coding RNA 7SK. Cyclin T1 is destabilized upon loss of hnRNP R, and Cyclin K interaction with CDK9 is enhanced. Transcriptome alterations overlap in cells lacking hnRNP R or 7SK.
Type of Medium:
Online Resource
ISSN:
1469-221X
,
1469-3178
DOI:
10.15252/embr.202255432
Language:
English
Publisher:
EMBO
Publication Date:
2022
detail.hit.zdb_id:
2025376-X
SSG:
12
Bookmarklink