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  • 1
    In: Advanced Pharmaceutical Bulletin, Maad Rayan Publishing Company, ( 2024-03-10)
    Abstract: Purpose: Lymphoma, the most predominant neoplastic disorder, is divided into Hodgkin and Non-Hodgkin Lymphoma classifications. Immunotherapeutic modalities have emerged as essential methodologies in combating lymphoid malignancies. Chimeric Antigen Receptor (CAR) T cells exhibit promising responses in chemotherapy-resistant B-cell non-Hodgkin lymphoma cases. Methods: This comprehensive review delineates the advancement of CAR-T cell therapy as an immunotherapeutic instrument, the selection of lymphoma antigens for CAR-T cell targeting, and the conceptualization, synthesis, and deployment of CAR-T cells. Furthermore, it encompasses the advantages and disadvantages of CAR-T cell therapy and the prospective horizons of CAR-T cells from a computational research perspective. In order to improve the design and functionality of artificial CARs, there is a need for TCR recognition investigation, followed by the implementation of a quality surveillance methodology. Results: Various lymphoma antigens are amenable to CAR-T cell targeting, such as CD19, CD20, CD22, CD30, the kappa light chain, and ROR1. A notable merit of CAR-T cell therapy is the augmentation of the immune system's capacity to generate tumoricidal activity in patients exhibiting chemotherapy-resistant lymphoma. Nevertheless, it also introduces manufacturing impediments that are laborious, technologically demanding, and financially burdensome. Physical, physicochemical, and physiological limitations further exacerbate the challenge of treating solid neoplasms with CAR-T cells. Conclusion: While the efficacy and safety of CAR-T cell immunotherapy remain subjects of fervent investigation, the promise of this cutting-edge technology offers valuable insights for the future evolution of lymphoma treatment management approaches. Moreover, CAR-T cell therapies potentially benefit patients, motivating regulatory bodies to foster international collaboration.
    Type of Medium: Online Resource
    ISSN: 2228-5881 , 2251-7308
    Language: English
    Publisher: Maad Rayan Publishing Company
    Publication Date: 2024
    detail.hit.zdb_id: 3018440-X
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  • 2
    Online Resource
    Online Resource
    PT Kalbe Farma Tbk. ; 2021
    In:  Cermin Dunia Kedokteran Vol. 48, No. 11 ( 2021-11-01), p. 318-324
    In: Cermin Dunia Kedokteran, PT Kalbe Farma Tbk., Vol. 48, No. 11 ( 2021-11-01), p. 318-324
    Abstract: This mini-review will discuss Cancer Stem Cells (CSCs) on their definition, history, characteristics, models, origin, tumorigenesis, targeting Cancer Stem Cells with nanomaterials, niche interactions, CSCs therapeutics, vaccination, the role of autophagy in CSCs, artificial intelligence, and clinical trials targeting CSCs. Mini review ini membahas sel punca kanker (Cancer Stem Cells), meliputi: definisi, sejarah, karakteristik, model, asal-mula, tumorigenesis, menarget CSCs dengan nanomaterial, interaksi niche, terapeutik berbasis CSCs, vaksinasi, peran autofagi pada CSCs, kecerdasan buatan, dan uji klinik menarget CSCs.
    Type of Medium: Online Resource
    ISSN: 2503-2720 , 0125-913X
    URL: Issue
    Language: Unknown
    Publisher: PT Kalbe Farma Tbk.
    Publication Date: 2021
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  • 3
    Online Resource
    Online Resource
    PT Kalbe Farma Tbk. ; 2021
    In:  Cermin Dunia Kedokteran Vol. 48, No. 11 ( 2021-11-01), p. 318-
    In: Cermin Dunia Kedokteran, PT Kalbe Farma Tbk., Vol. 48, No. 11 ( 2021-11-01), p. 318-
    Abstract: 〈 p 〉 This mini-review will discuss Cancer Stem Cells (CSCs) on their definition, history, characteristics, models, origin, tumorigenesis, targeting Cancer Stem Cells with nanomaterials, niche interactions, CSCs therapeutics, vaccination, the role of autophagy in CSCs, artificial intelligence, and clinical trials targeting CSCs. 〈 /p 〉 〈 p 〉   〈 /p 〉 〈 em 〉 Mini review 〈 /em 〉 ini membahas sel punca kanker ( 〈 em 〉 Cancer Stem Cells 〈 /em 〉 ), meliputi: definisi, sejarah, karakteristik, model, asal-mula, tumorigenesis, menarget CSCs dengan nanomaterial, interaksi 〈 em 〉 niche 〈 /em 〉 , terapeutik berbasis CSCs, vaksinasi, peran autofagi pada CSCs, kecerdasan buatan, dan uji klinik menarget CSCs. 〈 strong 〉 〈 /strong 〉
    Type of Medium: Online Resource
    ISSN: 2503-2720 , 0125-913X
    URL: Issue
    Language: Unknown
    Publisher: PT Kalbe Farma Tbk.
    Publication Date: 2021
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  • 4
    Online Resource
    Online Resource
    Universitas Muhammadiyah Surakarta ; 2023
    In:  Multicultural Islamic Education Review Vol. 1, No. 2 ( 2023-10-04), p. 63-82
    In: Multicultural Islamic Education Review, Universitas Muhammadiyah Surakarta, Vol. 1, No. 2 ( 2023-10-04), p. 63-82
    Abstract: Communication in the digital age has been transformed into more complicated ways due to various mediums and platforms based on information technology and digital devices. The digital age has brought about complex changes to communication through the use of technology and digital devices. It has more threats as well as benefits and innovations. In the meantime, many people who engaged in communication don’t fully take advantages but fall into miscommunication due to lack of digital literacy. In particular, in the field of health services, the threats of digital communication would make people, for instances the patients, in danger. While it offers benefits and innovations, it also brings new threats, particularly in the field of healthcare where miscommunication can harm patients mentally and physically. The miscommunication, misunderstanding etc. would harm their health mentally and physically. To address these issues, it is crucial to explore and analyze communication from multiple perspectives using scientific approaches. Hence, thinking and research on communication is extremely important. Various scientific approaches should be applied to analyze and sharpen communication in multiple perspectives. This manuscript discusses soft-skills of communication in the field of health issues of the digital era. This study is an attempt to invent the theoretical foundation of the ways in communication throughout analytical and philosophical approaches. It is Neurophilocommunication (NPC) that comprise of thoughts in communication that could be applied in the field of health issues on digital base and platforms.This study proposes NPC, a concept combining communication and neuroscience to enhance communication in healthcare in the digital era. The goal is to establish a theoretical foundation for effective communication and to improve the health outcomes of patients.
    Type of Medium: Online Resource
    ISSN: 3025-8839
    Language: Unknown
    Publisher: Universitas Muhammadiyah Surakarta
    Publication Date: 2023
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  • 5
    Online Resource
    Online Resource
    MedCrave Group Kft. ; 2022
    In:  International Physical Medicine & Rehabilitation Journal Vol. 7, No. 2 ( 2022-10-6), p. 100-104
    In: International Physical Medicine & Rehabilitation Journal, MedCrave Group Kft., Vol. 7, No. 2 ( 2022-10-6), p. 100-104
    Type of Medium: Online Resource
    ISSN: 2574-9838
    URL: Issue
    Language: Unknown
    Publisher: MedCrave Group Kft.
    Publication Date: 2022
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  • 6
    Online Resource
    Online Resource
    MedCrave Group Kft. ; 2022
    In:  International Physical Medicine & Rehabilitation Journal Vol. 7, No. 1 ( 2022), p. 12-12
    In: International Physical Medicine & Rehabilitation Journal, MedCrave Group Kft., Vol. 7, No. 1 ( 2022), p. 12-12
    Abstract: https://orcid.org/0000-0002-3292-3139
    Type of Medium: Online Resource
    ISSN: 2574-9838
    URL: Issue
    Language: Unknown
    Publisher: MedCrave Group Kft.
    Publication Date: 2022
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  • 7
    Online Resource
    Online Resource
    Riset Perkebunan Nusantara ; 2017
    In:  E-Journal Menara Perkebunan Vol. 85, No. 2 ( 2017-10-30)
    In: E-Journal Menara Perkebunan, Riset Perkebunan Nusantara, Vol. 85, No. 2 ( 2017-10-30)
    Abstract: Bioinformatics can be used to manage the data storage resulted from in silico molecular biology experiments. Off-network (offline) applications require large computing resources, in which researchers in the bioinformatics field of agriculture and health sectors do not necessarily possess. This review paper addressed examples of affordable and applicable in silico analytical cases in both mentioned sectors. Genome sequence analysis and in silico drug design using (1) a computational method, pharmacokinetic parameter prediction, (2) Computer Aided Design and Drafting (CADD) technology, (3) potential protein action prediction, (4) OMICs application in stem cell biology, and (5) lncRNAs based database computing internet sites is one of examples. In agriculture, bioinformatics-based research has been used in (1) the development of molecular markers; (2) the design of primer for differential gene expression analysis; (3) the development of genetic maps; and (4) gene expression analysis. Further application of bioinformatics also targets the design of applicative products for pest control and the protection of plant varieties in the farm. Through this example, novice researchers in the bioinformatics field of agriculture and health sectors can conduct sophisticated research using standard computer tools, internet networks, and sufficient knowledge about bioinformatics. On the other hand, multidisciplinary collaboration between these scientists can be carried out through social networking. The synergy can be directed to improve computing capabilities and data analysis via procurement of computing resources and use of public information clusters. [Key words: genome sequences, in silico drug design, online, bioinformatics, health, agriculture.] AbstrakBioinformatika dapat digunakan dalam manajemen informasi di bidang penyimpanan data in silico dari eksperimen biologi molekuler. Aplikasi luar jaringan (luring) memerlukan sumber daya komputasi yang besar, yang belum tentu dimiliki oleh para peneliti dalam bidang bioinformatika kesehatan dan pertanian. Kajian ilmiah ini membahas contoh kasus analisis in silico yang terjangkau dan aplikatif dalam bidang kesehatan dan pertanian. Contoh kasus tersebut adalah analisis sekuen genom dan desain obat in silico, menggunakan pendekatan metode komputasional, prediksi parameter farmakokinetik, teknologi Computer Aided Design and Drafting (CADD), prediksi potensial aksi protein, aplikasi OMICs pada biologi sel punca, hingga komputasi basis data lncRNAs berbasis situs internet. Pada bidang pertanian, penelitian berbasis bioinformatika telah digunakan dalam (1) pengembangan penanda molekuler; (2) desain primer untuk analisis ekspresi gen diferensial; (3) pengembangan peta genetik; dan (4) analisis ekspresi gen. Pemanfaatan bio-informatika dalam ilmu terapan dibidang pertanian juga menyasar desain produk aplikatif untuk pengendalian hama dan perlindungan varietas tanaman. Melalui contoh tersebut, peneliti pemula dibidang bioinformatika kesehatan dan pertanian dapat melakukan penelitian canggih hanya dengan alat komputer standar, jaringan internet, dan pengetahuan mencukupi tentang bioinformatika. Disisi lain, sinergi dan kolaborasi antar peneliti multi-displiner dapat dilakukan melalui penggunaan jejaring sosial. Sinergi tersebut dapat diarahkan untuk meningkatkan kemampuan komputasi dan analisis data melalui pengadaan sumber daya komputasi dan penggunaan klaster informatika publik.[Kata kunci: sekuen genom, desain obat in silico, daring, bioinformatika, kesehatan, pertanian]
    Type of Medium: Online Resource
    ISSN: 1858-3768 , 0125-9318
    Language: Unknown
    Publisher: Riset Perkebunan Nusantara
    Publication Date: 2017
    detail.hit.zdb_id: 3017799-6
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  • 8
    Online Resource
    Online Resource
    International Journal of Human and Health Sciences IJHHS ; 2020
    In:  International Journal of Human and Health Sciences (IJHHS) Vol. 5, No. 2 ( 2020-10-04), p. 177-
    In: International Journal of Human and Health Sciences (IJHHS), International Journal of Human and Health Sciences IJHHS, Vol. 5, No. 2 ( 2020-10-04), p. 177-
    Abstract: COVID-19 pandemic is not slowing down, while the government from various countries is currently designing the ‘new normal’ to restart back their economy. Up to now, there is a significant mortality rate in the health care professionals that act as the frontliners in the hospitals and clinics in battling the COVID-19 menace. Based on computational sciences studied since the 1960s, artificial intelligence (AI) could assist healthcare professionals to protect themselves from the SARS-CoV-2 virus and treat the patients in an efficient and secure manner. AI, starting from the diagnosis, treatment, medication, until the prediction of the next pandemic, could assist in various areas. The objective of this review is to highlight AI in the health sciences in order to assist healthcare professionals in facing the COVID-19 pandemic, and the threat of the future pandemics.International Journal of Human and Health Sciences Vol. 05 No. 02 April’21 Page: 177-184
    Type of Medium: Online Resource
    ISSN: 2523-692X
    Language: Unknown
    Publisher: International Journal of Human and Health Sciences IJHHS
    Publication Date: 2020
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  • 9
    In: Nanomaterials, MDPI AG, Vol. 12, No. 17 ( 2022-08-26), p. 2948-
    Abstract: Globally, breast cancer is one of the most prevalent diseases, inducing critical intimidation to human health. Lipid-based nanomaterials have been successfully demonstrated as drug carriers for breast cancer treatment. To date, the development of a better drug delivery system based on lipid nanomaterials is still urgent to make the treatment and diagnosis easily accessible to breast cancer patients. In a drug delivery system, lipid nanomaterials have revealed distinctive features, including high biocompatibility and efficient drug delivery. Specifically, a targeted drug delivery system based on lipid nanomaterials has inherited the advantage of optimum dosage and low side effects. In this review, insights on currently used potential lipid-based nanomaterials are collected and introduced. The review sheds light on conjugation, targeting, diagnosis, treatment, and clinical significance of lipid-based nanomaterials to treat breast cancer. Furthermore, a brighter side of lipid-based nanomaterials as future potential drug delivery systems for breast cancer therapy is discussed.
    Type of Medium: Online Resource
    ISSN: 2079-4991
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2662255-5
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  • 10
    Online Resource
    Online Resource
    PT. Sanskara Karya Internasional ; 2023
    In:  West Science Interdisciplinary Studies Vol. 1, No. 09 ( 2023-09-27), p. 743-753
    In: West Science Interdisciplinary Studies, PT. Sanskara Karya Internasional, Vol. 1, No. 09 ( 2023-09-27), p. 743-753
    Abstract: Mental health disorders among adolescents in West Java have become a growing concern, impacting their well-being and future prospects. This study aimed to investigate the genetic factors contributing to these disorders, utilizing genomic analysis and qualitative exploration of lived experiences. A mixed-methods approach was employed, including quantitative surveys, genomic analysis, and qualitative interviews. The study comprised a diverse sample of adolescents from various socio-economic backgrounds and age groups in West Java. The quantitative analysis revealed a significant prevalence of mental health disorders, with approximately 35% reporting symptoms of depression and 55% meeting criteria for generalized anxiety disorder. Genomic analysis identified specific genetic markers associated with these disorders, emphasizing their genetic underpinnings. Qualitative data underscored the impact of stigma, coping mechanisms, family support, and cultural factors on adolescents' mental well-being. The findings of this study provide a comprehensive understanding of mental health in adolescents in West Java, integrating genetic and socio-cultural perspectives. The prevalence rates highlight the urgency of addressing mental health issues in this population. Genetic insights suggest opportunities for personalized interventions, while qualitative findings emphasize the importance of reducing stigma and enhancing community-based support. These findings contribute to the development of targeted interventions and policies aimed at improving the mental health of adolescents in West Java.
    Type of Medium: Online Resource
    ISSN: 2985-8895
    URL: Issue
    Language: Unknown
    Publisher: PT. Sanskara Karya Internasional
    Publication Date: 2023
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