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Plasmablasts During Acute Dengue Infection Represent a Small Subset of a Broader Virus-specific Memory B Cell Pool

Appanna, Ramapraba ; KG, Srinivasan ; Xu, Mei Hui ; [et al.]

Elsevier BV ; 2016

In: EBioMedicine Vol. 12 ( 2016-10), p. 178-188

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In: EBioMedicine, Elsevier BV, Vol. 12 ( 2016-10), p. 178-188

Type of Medium: Online Resource

ISSN: 2352-3964

URL: Article

DOI: 10.1016/j.ebiom.2016.09.003

Language: English

Publisher: Elsevier BV

Publication Date: 2016

detail.hit.zdb_id: 2799017-5

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Susceptible and Protective HLA Class 1 Alleles against Dengue Fever and Dengue Hemorrhagic Fever Patients in a Malaysian Population

Appanna, Ramapraba ; Ponnampalavanar, Sasheela ; Lum Chai See, Lucy ; [et al.]

Public Library of Science (PLoS) ; 2010

In: PLoS ONE Vol. 5, No. 9 ( 2010-9-28), p. e13029-

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In: PLoS ONE, Public Library of Science (PLoS), Vol. 5, No. 9 ( 2010-9-28), p. e13029-

Type of Medium: Online Resource

ISSN: 1932-6203

URL: Article

DOI: 10.1371/journal.pone.0013029

DOI: 10.1371/journal.pone.0013029.t001

DOI: 10.1371/journal.pone.0013029.t002

DOI: 10.1371/journal.pone.0013029.t003

DOI: 10.1371/journal.pone.0013029.t004

DOI: 10.1371/journal.pone.0013029.t005

DOI: 10.1371/journal.pone.0013029.t006

DOI: 10.1371/journal.pone.0013029.t007

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2010

detail.hit.zdb_id: 2267670-3

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Food Allergy and Intolerance: A Narrative Review on Nutritional Concerns

Gargano, Domenico ; Appanna, Ramapraba ; Santonicola, Antonella ; [et al.]

MDPI AG ; 2021

In: Nutrients Vol. 13, No. 5 ( 2021-05-13), p. 1638-

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In: Nutrients, MDPI AG, Vol. 13, No. 5 ( 2021-05-13), p. 1638-

Abstract: Adverse food reactions include immune-mediated food allergies and non-immune-mediated intolerances. However, this distinction and the involvement of different pathogenetic mechanisms are often confused. Furthermore, there is a discrepancy between the perceived vs. actual prevalence of immune-mediated food allergies and non-immune reactions to food that are extremely common. The risk of an inappropriate approach to their correct identification can lead to inappropriate diets with severe nutritional deficiencies. This narrative review provides an outline of the pathophysiologic and clinical features of immune and non-immune adverse reactions to food—along with general diagnostic and therapeutic strategies. Special emphasis is placed on specific nutritional concerns for each of these conditions from the combined point of view of gastroenterology and immunology, in an attempt to offer a useful tool to practicing physicians in discriminating these diverging disease entities and planning their correct management. We conclude that a correct diagnostic approach and dietary control of both immune- and non-immune-mediated food-induced diseases might minimize the nutritional gaps in these patients, thus helping to improve their quality of life and reduce the economic costs of their management.

Type of Medium: Online Resource

ISSN: 2072-6643

URL: Article

DOI: 10.3390/nu13051638

Language: English

Publisher: MDPI AG

Publication Date: 2021

detail.hit.zdb_id: 2518386-2

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Cross-Reactive T-Cell Responses to the Nonstructural Regions of Dengue Viruses among Dengue Fever and Dengue Hemorrhagic Fever Patients in Malaysia

Appanna, Ramapraba ; Huat, Tan Lian ; See, Lucy Lum Chai ; [et al.]

American Society for Microbiology ; 2007

In: Clinical and Vaccine Immunology Vol. 14, No. 8 ( 2007-08), p. 969-977

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In: Clinical and Vaccine Immunology, American Society for Microbiology, Vol. 14, No. 8 ( 2007-08), p. 969-977

Abstract: Dengue virus infections are a major cause of morbidity and mortality in tropical and subtropical areas in the world. Attempts to develop effective vaccines have been hampered by the lack of understanding of the pathogenesis of the disease and the absence of suitable experimental models for dengue viral infection. The magnitude of T-cell responses has been reported to correlate with dengue disease severity. Sixty Malaysian adults with dengue viral infections were investigated for their dengue virus-specific T-cell responses to 32 peptides antigens from the structural and nonstructural regions from a dengue virus isolate. Seventeen different peptides from the C, E, NS2B, NS3, NS4A, NS4B, and NS5 regions were found to evoke significant responses in a gamma interferon enzyme-linked immunospot (ELISPOT) assay of samples from 13 selected patients with dengue fever (DF) and dengue hemorrhagic fever (DHF). NS3 and predominantly NS3 422-431 were found to be important T-cell targets. The highest peaks of T-cell responses observed were in responses to NS3 422-431 and NS5 563-571 in DHF patients. We also found almost a sevenfold increase in T-cell response in three DHF patients compared to three DF patient responses to peptide NS3 422-431 . A large number of patients' T cells also responded to the NS2B 97-106 region. The ELISPOT analyses also revealed high frequencies of T cells that recognize both serotype-specific and cross-reactive dengue virus antigens in patients with DHF.

Type of Medium: Online Resource

ISSN: 1556-6811 , 1556-679X

URL: Article

DOI: 10.1128/CVI.00069-07

Language: English

Publisher: American Society for Microbiology

Publication Date: 2007

detail.hit.zdb_id: 1496863-0

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Correction: Susceptible and Protective HLA Class 1 Alleles against Dengue Fever and Dengue Hemorrhagic Fever Patients in a Malaysian Population

Appanna, Ramapraba ; Ponnampalavanar, Sasheela ; Lum Chai See, Lucy ; [et al.]

Public Library of Science (PLoS) ; 2011

In: PLoS ONE Vol. 6, No. 1 ( 2011-1-27)

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In: PLoS ONE, Public Library of Science (PLoS), Vol. 6, No. 1 ( 2011-1-27)

Type of Medium: Online Resource

ISSN: 1932-6203

URL: Article

DOI: 10.1371/annotation/972cc8f0-5c9e-4d74-b98b-217a2f80a4bd

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2011

detail.hit.zdb_id: 2267670-3

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Plasmablasts Generated during Repeated Dengue Infection Are Virus Glycoprotein–Specific and Bind to Multiple Virus Serotypes

Xu, MeiHui ; Hadinoto, Vey ; Appanna, Ramapraba ; [et al.]

The American Association of Immunologists ; 2012

In: The Journal of Immunology Vol. 189, No. 12 ( 2012-12-15), p. 5877-5885

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In: The Journal of Immunology, The American Association of Immunologists, Vol. 189, No. 12 ( 2012-12-15), p. 5877-5885

Abstract: Dengue virus immune protection is specific to the serotype encountered and is thought to persist throughout one’s lifetime. Many serotype cross-reactive memory B cells isolated from humans with previous dengue infection are specific for the nonstructural and the prM structural viral proteins, and they can enhance infection in vitro. However, plasmablasts circulating in enormous numbers during acute secondary infection have not been studied. In this study, we analyzed single plasmablasts from two patients by sorting the cells for Ig sequence analysis and for recombinant expression of Abs. In contrast to memory B cells, most plasmablast-derived Abs bound to the structural E protein of dengue, and protection experiments in mice revealed that virus serotypes encountered during past infections were neutralized more efficiently than were the serotypes of the current infection. Together with genetic analyses, we show evidence that plasmablasts in dengue patients are a polyclonal pool of activated E protein–specific memory B cells and that their specificity is not representative of the serum Abs secreted by long-lived plasma cells in the memory phase. These results contribute to the understanding of the phenomenon of original antigenic sin in dengue.

Type of Medium: Online Resource

ISSN: 0022-1767 , 1550-6606

URL: Article

DOI: 10.4049/jimmunol.1201688

RVK:

XA 54100

RVK:

XA 10000

Language: English

Publisher: The American Association of Immunologists

Publication Date: 2012

detail.hit.zdb_id: 1475085-5

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A nonstructural protein 1 capture enzyme-linked immunosorbent assay specific for dengue viruses

Lim, Pei-Yin ; Ramapraba, Appanna ; Loy, Thomas ; [et al.]

Public Library of Science (PLoS) ; 2023

In: PLOS ONE Vol. 18, No. 5 ( 2023-5-18), p. e0285878-

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In: PLOS ONE, Public Library of Science (PLoS), Vol. 18, No. 5 ( 2023-5-18), p. e0285878-

Abstract: Dengue non-structural protein (NS1) is an important diagnostic marker during the acute phase of infection. Because NS1 is partially conserved across the flaviviruses, a highly specific DENV NS-1 diagnostic test is needed to differentiate dengue infection from Zika virus (ZIKV) infection. In this study, we characterized three newly isolated antibodies against NS1 (A2, D6 and D8) from a dengue-infected patient and a previously published human anti-NS1 antibody (Den3). All four antibodies recognized multimeric forms of NS1 from different serotypes. A2 bound to NS1 from DENV-1, -2, and -3, D6 bound to NS1 from DENV-1, -2, and -4, and D8 and Den3 interacted with NS1 from all four dengue serotypes. Using a competition ELISA, we found that A2 and D6 bound to overlapping epitopes on NS1 whereas D8 recognized an epitope distinct from A2 and D6. In addition, we developed a capture ELISA that specifically detected NS1 from dengue viruses, but not ZIKV, using Den3 as the capture antibody and D8 as the detecting antibody. This assay detected NS1 from all the tested dengue virus strains and dengue-infected patients. In conclusion, we established a dengue-specific capture ELISA using human antibodies against NS1. This assay has the potential to be developed as a point-of-care diagnostic tool.

Type of Medium: Online Resource

ISSN: 1932-6203

URL: Article

DOI: 10.1371/journal.pone.0285878

DOI: 10.1371/journal.pone.0285878.g001

DOI: 10.1371/journal.pone.0285878.g002

DOI: 10.1371/journal.pone.0285878.g003

DOI: 10.1371/journal.pone.0285878.g004

DOI: 10.1371/journal.pone.0285878.g005

DOI: 10.1371/journal.pone.0285878.g006

DOI: 10.1371/journal.pone.0285878.t001

DOI: 10.1371/journal.pone.0285878.s001

DOI: 10.1371/journal.pone.0285878.s002

DOI: 10.1371/journal.pone.0285878.s003

DOI: 10.1371/journal.pone.0285878.r001

DOI: 10.1371/journal.pone.0285878.r002

DOI: 10.1371/journal.pone.0285878.r003

DOI: 10.1371/journal.pone.0285878.r004

DOI: 10.1371/journal.pone.0285878.r005

DOI: 10.1371/journal.pone.0285878.r006

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2023

detail.hit.zdb_id: 2267670-3

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CD27hiCD38hi plasmablasts are activated B cells of mixed origin with distinct function

Rouers, Angeline ; Appanna, Ramapraba ; Chevrier, Marion ; [et al.]

Elsevier BV ; 2021

In: iScience Vol. 24, No. 5 ( 2021-05), p. 102482-

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In: iScience, Elsevier BV, Vol. 24, No. 5 ( 2021-05), p. 102482-

Type of Medium: Online Resource

ISSN: 2589-0042

URL: Article

DOI: 10.1016/j.isci.2021.102482

Language: English

Publisher: Elsevier BV

Publication Date: 2021

detail.hit.zdb_id: 2927064-9

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CD27 〈sup〉hi〈/sup〉CD38 〈sup〉hi〈/sup〉 Plasmablasts are Activated B Cells of Mixed Origin with Distinct Function

Rouers, Angeline ; Appanna, Ramapraba ; Chevrier, Marion ; [et al.]

Elsevier BV ; 2020

In: SSRN Electronic Journal

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In: SSRN Electronic Journal, Elsevier BV

Type of Medium: Online Resource

ISSN: 1556-5068

URL: Article

DOI: 10.2139/ssrn.3631403

Language: English

Publisher: Elsevier BV

Publication Date: 2020

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Human poly- and cross-reactive anti-viral antibodies and their impact on protection and pathology

Warter, Lucile ; Appanna, Ramapraba ; Fink, Katja

Springer Science and Business Media LLC ; 2012

In: Immunologic Research Vol. 53, No. 1-3 ( 2012-9), p. 148-161

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In: Immunologic Research, Springer Science and Business Media LLC, Vol. 53, No. 1-3 ( 2012-9), p. 148-161

Type of Medium: Online Resource

ISSN: 0257-277X , 1559-0755

URL: Article

DOI: 10.1007/s12026-012-8268-8

RVK:

YC 5122

RVK:

YC 5187

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2012

detail.hit.zdb_id: 2079303-0

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